Dengue Outbreak 2018 in District Shangla KPK; Clinical Features and Laboratory Markers of Dengue Virus Infection

Anwar, Faheem; Tayyab, Muhammad; Salman, Muhammad; Abdullah, .; Din, Misbahud; Khan, Jehangir; Haq, Ihteshamul

doi:10.2217/fvl-2019-0130

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…Other illnesses such as myalgia (100%), headache (61.31%), vomiting (34.63%), rashes (22.62%), and pain in the abdomen (28.91%), were identified as the highest in dengue affected persons when compared with the negative group. Our findings are inconsistent with the studies reported before, 23,28 which may be due to variance in the strain or virulence factor of the virus. But another study keeps relevant 29 …”

Section: Discussioncontrasting

confidence: 99%

Epidemiological and hematological investigation of dengue virus infection

Anwar

Ullah

Aziz

et al. 2022

Microbiology and Immunology

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Dengue is a mosquito-borne viral illness that infects humans. For the past few decades, it has been declared a global public health problem. The current study, conducted at the district headquarter hospital (DHQ) Bannu between June to September 2018, was based on the seroprevalence of antibodies against dengue virus serotypes and their hematological parameters among the patients. A total of 1738 individuals suspected of having dengue were diagnosed through NS1, IgG, and IgM antibodies and RT-PCR techniques. Of all the samples, 716 (41.19%) were found to be positive for dengue. A higher infection rate was found in males (65.92%) compared with females (34.07%). The most affected age group was 16-40 years, whereas the most affected tehsil was Bannu, where the DENV-3 serotype was prevalent. The rare serotype (DENV-4) was found in 1% of cases. Symptoms including fever (100%), myalgia (100%), headache (61.31%), vomiting (34.63%), and rashes were common among the dengue patients. However, the mild cases showed fewer clinical signs compared with the severely infected cases. The study also revealed a significant association (P < 0.05) between hematological parameters and dengue infection, showing a significant decrease in TC, eosinophils, neutrophils, and platelets and a significant increase in monocytes and lymphocytes. Based on the current report, it is concluded that patients with the above symptoms and hematological changes may have an increased probability of dengue and should be kept under observation to separate dengue-positive patients and to enhance the treatment process.

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Section: Discussioncontrasting

confidence: 99%

Epidemiological and hematological investigation of dengue virus infection

Anwar

Ullah

Aziz

et al. 2022

Microbiology and Immunology

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“…The infected individuals could represent several symptoms including high fever, headache, pain in joints, and myalgia 7 . In the last decade, Pkistan experienced huge outbreaks in which main serotypes DENV-2, DENV-3, DENV-4 were found in Punjab, nevertheless, in Swat and Shangla areas of KP province only DENV-2, DENV-3 was reported from 2013 to 2018 8 , 9 , 10 . Recent studies have reported that dengue virus infection is endemic in Pakistan, where the highest incidences have been reported in the monsoon season 11 , 12 .…”

Section: Introductionmentioning

confidence: 99%

Incidence of Dengue fever, serotypes, clinical features, and laboratory markers: a case study of 2019 outbreak at district Shangla, KP, Pakistan

Rehman¹,

Anwar²,

Tayyab³

et al. 2022

Afr H. Sci.

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Background: Dengue is a widely spread mosquito-borne infection in humans, which in recent decades declared is public health problem globally. The dengue virus contains 4 different serotypes (DENV-1, DENV-2, DENV-3, and DENV-4) which belong to the genus Flavivirus. Aims: A descriptive experimental study was conducted to determine the epidemiology, types of Dengue serotypes, clinical features, laboratory probe, and markers for primary diagnosis of dengue virus infection in hospitalized patients. Methodology: A total of 691 suspects were diagnosed from August to October 2019 in district Shangla KP, Pakistan. Serological tests were used for nonstructural protein-1 antigen (NS1), and antibodies (immunoglobulin-M (IgM) & Immunoglobulin-G (IgG)) while real-time PCR was used to confirm the cases. The data was statistically analyzed using IBM-SPSS Statistics 20 version. Results: The dengue virus infection was more prevalent in the male group (68.09%) than the female group (31.1%). A large number of patients were from rural areas (63.5%) while from urban areas were (36.4%), whereas Besham tehsil was found the most affected compared to other regions. The most prevalent serotype observed in our study was DENV-3 (56.60%) while DENV-4 was the least prevalent serotype (1.88%). Among the age-wise analysis of dengue-virus-infected individuals, the age group of 19–37 years (64.07%) was found the most affected group. The month-wise analysis revealed that the highest number of infections (49.8%) were recorded in September. Significant differences were noticed among blood parameters. Conclusion: The possible reasons for the dengue overwhelming in the study area could be less or lack of awareness particularly regarding the transmission of viral infections, improper sewage management, and no effective vector control strategies that lead the dengue outbreaks in the study population. Keywords: Dengue; Outbreak; DENV; real-time PCR; RNA Virus; Pakistan.

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“…Few studies also showed some conflicting results [19,20]. On the other hand, several findings suggest that, safety profile of Remdesivir was also comparable or to somewhat similar to placebo [21,22].Furthermore, This Research Shows greater Remdesivir efficacy in earlier start of COVID-19 treatment.…”

Section: Resultsmentioning

confidence: 88%

Evaluation of the Remdesivir Treatment of Non-Hospitalized Patients with COVID-19

Hanan¹,

Haq²,

Ahmed³

et al. 2022

PJMHS

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Novel corona virus 2019 has resulted in a pandemic which killed over five million people worldwide. It causes acute respiratory syndrome and is reported to affect multi-organ system. Various variant of corona virus (COVID-19) has been emerged in various regions of the world as a result of mutation in original strains. The Purpose of the Current Study to evaluate the effect of Remdesivir for treating non-hospitalized patients with COVID-19 at the Department of Medicine PIMS Hospital from 1st January 2021 to 30th June 2021. In the Current Research One hundred patients were enrolled and divided into group A and group B within the age of 24-70 years. Group A was receiving Remdesivir while group B is not receiving Remdesivir. The clinical variables, BMI, Comorbidities, duration of disease severity and viral load were determined. RT-PCR was conducted to determine viral load. The mean age of study participants was 50±15 years with greater number of males. Diabetes was the major comorbidity. The time duration was decreased in group A upto 5 days and 8 days in group B. The viral load was decreased by mean value 6.32±1.76 to 6.2±1.78 in group B then group A respectively and result show that Remdesivir is effective in COVID-19 treatment. Keywords: Remdesivir, COVID-19, Viral load

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Dengue Outbreak 2018 in District Shangla KPK; Clinical Features and Laboratory Markers of Dengue Virus Infection

Cited by 8 publications

References 26 publications

Epidemiological and hematological investigation of dengue virus infection

Epidemiological and hematological investigation of dengue virus infection

Incidence of Dengue fever, serotypes, clinical features, and laboratory markers: a case study of 2019 outbreak at district Shangla, KP, Pakistan

Evaluation of the Remdesivir Treatment of Non-Hospitalized Patients with COVID-19

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