Dengue: Lessons of an Outbreak

Siddiqui, Oves; Chakravarti, Anita; Abhishek, Kumar S

doi:10.7860/jcdr/2016/19238.7927

Cited by 5 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of secondary dengue infection varied in different studies. Two studies by Sidique O et al 15 and Changal K et al 14 reported the prevalence of secondary dengue infection as 68.4 % and 66.7% respectively, which was higher compared to our study results. However, Kumar et al 16 reported the prevalence of secondary dengue infection as 50%.…”

Section: Discussioncontrasting

confidence: 86%

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Joena¹,

R²

2019

IJCMR

View full text Add to dashboard Cite

Introduction: Even after the discovery of vaccines for dengue fever, it remains a major public health problem in developing tropical and subtropical countries, especially in India. The dengue fever has a varied clinical spectrum ranging from a mild headache to severe organ impairment or bleeding, depending on the virulence and susceptibility of the individual. The current study investigated the clinical profile of laboratoryconfirmed dengue patients. A secondary objective was to find the role of haematological parameters in prognosis. Material and Methods: This was a retrospective study conducted in a tertiary care hospital at Madurai following a dengue fever outbreak between August 2017 to November 2017 among laboratory-confirmed dengue patients older than 16 years. All the relevant clinical and laboratory investigation details of the patients were obtained from the medical records of the hospital. Results: Fever was present in all the cases with an average duration of 4.86 ± 1.59 days followed by myalgia (57.39%), vomiting (46.96%), headache (30.43%) and abdominal pain (20%). Bleeding and hepatic complication was presented by 22.16% and 50.43%. The mean platelet recovery duration was 8.42 ± 1.74 days. A strong positive correlation between day of recovery (increasing trend of platelet) from the onset of fever and WBC recovery (r s value: 0.0.713, P value: <0.001) was observed. Conclusion: Dengue fever patients have varied clinical features varying from fever to severe hepatic complication. For assessing the prognosis of dengue fever, along with the continuous monitoring of clinical profile and platelet count, evaluation of WBC recovery is also recommended.

show abstract

Section: Discussioncontrasting

confidence: 86%

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Joena¹,

R²

2019

IJCMR

View full text Add to dashboard Cite

show abstract

“…The WHO predicts an incidence of 50–100 dengue million cases and ~ 20,000 dengue-related deaths per year, and nearly 40% of the world’s population lives in areas with a risk of DENV transmission [31]. India is estimated to contribute 34% of the total global burden of dengue [32], and suffered several outbreaks of severe dengue over the last few years [33–36]. There were 129,166 reported cases with 245 deaths in 2016 (NVBDCP).…”

Section: Discussionmentioning

confidence: 99%

Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India

et al. 2019

View full text Add to dashboard Cite

Background We conducted a diagnostic surveillance study to identify Plasmodium , dengue virus, chikungunya virus, and Orientia tsutsugamushi infections among febrile patients who underwent triage for malaria in the outpatient department at Ispat General Hospital, Rourkela, Odisha, India. Methods Febrile patients were enrolled from January 2016–January 2017. Blood smears and small volumes or vacutainers of blood were collected from study participants to carry out diagnostic assays. Malaria was diagnosed using rapid diagnostic tests (RDT), microscopy, and PCR. Dengue, chikungunya, and scrub typhus infections were identified using rapid diagnostic test kits and ELISA. Results Nine hundred and fifty-four patients were prospectively enrolled in our study. The majority of patients were male (58.4%) and more than 15 years of age (66.4%). All 954 enrollees underwent additional testing for malaria; a subset of enrollees (293/954) that had larger volumes of plasma available was also tested for dengue, chikungunya and scrub typhus by either RDT or ELISA or both tests. Fifty-four of 954 patients (5.7%) were positive for malaria by RDT, or microscopy, or PCR. Seventy-four of 293 patients (25.3%) tested positive for dengue by either RDT or ELISA, and 17 of 293 patients (5.8%) tested positive for chikungunya-specific IgM by either ELISA or RDT. Ten of 287 patients tested (3.5%) were positive for scrub typhus by ELISA specific for scrub typhus IgM. Seventeen patients among 290 (5.9%) with results for ≥3 infections tested positive for more than one infection. Patients with scrub typhus and chikungunya had high rates of co-infection: of the 10 patients positive for scrub typhus, six were positive for dengue ( p = 0.009), and five of 17 patients positive for chikungunya (by RDT or ELISA) were also diagnosed with malaria ( p < 0.001). Conclusions Dengue, chikungunya and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, and comorbidity should be considered. Routine febrile illness surveillance is required to accurately establish the prevalence of these infections in this region, to offer timely treatment, and to implement appropriate methods of control. Electronic supplementary material The online version of this article (10.1186/s12879-019-4161-6) contains supplementary material, which is available to authorized users.

show abstract

“…Dengue and severe dengue because of immune enhancement due to a previous infection with another serotype is an increasing problem in India [ 14 , 15 ]. India is estimated to contribute 34% (33/96 million) of the total global burden of dengue [ 16 ], with increasing incidence both of dengue and outbreaks of severe dengue [ 17 , 18 ]. The risk of severe dengue is high, as more than 25% of the population in Delhi has been reported to have had a past infection [ 17 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…India is estimated to contribute 34% (33/96 million) of the total global burden of dengue [ 16 ], with increasing incidence both of dengue and outbreaks of severe dengue [ 17 , 18 ]. The risk of severe dengue is high, as more than 25% of the population in Delhi has been reported to have had a past infection [ 17 , 19 ]. In line with the high prevalence reported in previous studies, dengue was found in as much as 16% (244/1564) in the present study, highest in the sites in South- and West India.…”

Section: Discussionmentioning

confidence: 99%

Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy

et al. 2017

View full text Add to dashboard Cite

BackgroundThe objectives of this study were to determine the proportion of malaria, bacteraemia, scrub typhus, leptospirosis, chikungunya and dengue among hospitalized patients with acute undifferentiated fever in India, and to describe the performance of standard diagnostic methods.MethodsDuring April 2011–November 2012, 1564 patients aged ≥5 years with febrile illness for 2–14 days were consecutively included in an observational study at seven community hospitals in six states in India.Malaria microscopy, blood culture, Dengue rapid NS1 antigen and IgM Combo test, Leptospira IgM ELISA, Scrub typhus IgM ELISA and Chikungunya IgM ELISA were routinely performed at the hospitals.Second line testing, Dengue IgM capture ELISA (MAC-ELISA), Scrub typhus immunofluorescence (IFA), Leptospira Microscopic Agglutination Test (MAT), malaria PCR and malaria immunochromatographic rapid diagnostic test (RDT) Parahit Total™ were performed at the coordinating centre. Convalescence samples were not available.Case definitions were as follows: Leptospirosis: Positive ELISA and positive MAT. Scrub typhus: Positive ELISA and positive IFA. Dengue: Positive RDT and/or positive MAC-ELISA. Chikungunya: Positive ELISA. Bacteraemia: Growth in blood culture excluding those defined as contaminants. Malaria: Positive genus-specific PCR.ResultsMalaria was diagnosed in 17% (268/1564) and among these 54% had P. falciparum. Dengue was diagnosed in 16% (244/1564). Bacteraemia was found in 8% (124/1564), and among these Salmonella typhi or S. paratyphi constituted 35%. Scrub typhus was diagnosed in 10%, leptospirosis in 7% and chikungunya in 6%. Fulfilling more than one case definition was common, most frequent in chikungunya where 26% (25/98) also had positive dengue test.ConclusionsMalaria and dengue were the most common causes of fever in this study. A high overlap between case definitions probably reflects high prevalence of prior infections, cross reactivity and subclinical infections, rather than high prevalence of coinfections. Low accuracy of routine diagnostic tests should be taken into consideration when approaching the patient with acute undifferentiated fever in India.

show abstract

Dengue: Lessons of an Outbreak

Cited by 5 publications

References 12 publications

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Clinical Profile and Role of Haematological Parameters in the Prognosis of Dengue Fever Patients Admitted in a Tertiary Hospital

Dengue, chikungunya, and scrub typhus are important etiologies of non-malarial febrile illness in Rourkela, Odisha, India

Acute undifferentiated fever in India: a multicentre study of aetiology and diagnostic accuracy

Contact Info

Product

Resources

About