Dengue infection

Guzmán, María G.; Gubler, Duane J.; Izquierdo, Alienys; Martínez, Eric; Halstead, Scott B.

doi:10.1038/nrdp.2016.55

Cited by 529 publications

(615 citation statements)

References 264 publications

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“…Primary infection by DENV leads to long-term protection against the serotype of infection (homologous serotype) but not other serotypes (heterologous serotypes) [5–7]. Subsequent secondary infection with a new serotype results in serotype cross-neutralizing antibodies that correlate with durable protection against 2 or more serotypes [5, 7]. Recent studies have defined the properties of human antibodies responsible for serotype-specific neutralization after primary infection [8–12].…”

Section: Introductionmentioning

confidence: 99%

Dissecting the human serum antibody response to secondary dengue virus infections

et al. 2017

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Dengue viruses (DENVs) are mosquito-borne flaviviruses and the causative agents of dengue fever and dengue hemorrhagic fever. As there are four serotypes of DENV (DENV1-4), people can be infected multiple times, each time with a new serotype. Primary infections stimulate antibodies that mainly neutralize the serotype of infection (type-specific), whereas secondary infections stimulate responses that cross-neutralize 2 or more serotypes. Previous studies have demonstrated that neutralizing antibodies induced by primary infections recognize tertiary and quaternary structure epitopes on the viral envelope (E) protein that are unique to each serotype. The goal of the current study was to determine the properties of neutralizing antibodies induced after secondary infection with a different (heterotypic) DENV serotypes. We evaluated whether polyclonal neutralizing antibody responses after secondary infections consist of distinct populations of type-specific antibodies to each serotype encountered or a new population of broadly cross-neutralizing antibodies. We observed two types of responses: in some individuals exposed to secondary infections, DENV neutralization was dominated by cross-reactive antibodies, whereas in other individuals both type-specific and cross-reactive antibodies contributed to neutralization. To better understand the origins of type-specific and cross-reactive neutralizing antibodies, we analyzed sera from individuals with well-documented sequential infections with two DENV serotypes only. These individuals had both type-specific and cross-reactive neutralizing antibodies to the 2 serotypes responsible for infection and only cross-reactive neutralizing antibodies to other serotypes. Collectively, the results demonstrate that the quality of neutralizing (and presumably protective) antibodies are different in individuals depending on the number of previous exposures to different DENV serotypes. We propose a model in which low affinity, cross-reactive antibody secreting B-cell clones induced by primary exposure evolve during each secondary infection to secrete higher affinity and more broadly neutralizing antibodies.

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Section: Introductionmentioning

confidence: 99%

Dissecting the human serum antibody response to secondary dengue virus infections

et al. 2017

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“…12 Rarely progression to severe dengue can result in plasma leakage that leads to respiratory distress, shock, severe bleeding, and death. 12 …”

Section: Introductionmentioning

confidence: 99%

Biochemistry and Molecular Biology of Flaviviruses

et al. 2018

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Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. Most of these pathogens are transmitted by mosquitos, and not surprisingly, as the earth warms and human populations grow and move, their geographic reach is increasing. Flaviviruses are simple RNA–protein machines that carry out protein synthesis, genome replication, and virion packaging in close association with cellular lipid membranes. In this review, we examine the molecular biology of flaviviruses touching on the structure and function of viral components and how these interact with host factors. The latter are functionally divided into pro-viral and antiviral factors, both of which, not surprisingly, include many RNA binding proteins. In the interface between the virus and the hosts we highlight the role of a noncoding RNA produced by flaviviruses to impair antiviral host immune responses. Throughout the review, we highlight areas of intense investigation, or a need for it, and potential targets and tools to consider in the important battle against pathogenic flaviviruses.

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“…Pada usia yang lebih lanjut, IgG maternal nonneutralizing ini akan menghilang seutuhnya sehingga risiko terjadinya manifestasi parah pada anak atau dewasa akan lebih rendah dibandingkan pada usia bayi. 3,10 Pada penelitian ini, temuan sejalan dengan teori yang menyatakan bahwa mayoritas pasien dengue bayi adalah berumur 4-12. Penelitian ini juga sejalan dengan penelitian tahun 2010 di Lucknow, India, 4 yang melaporkan bahwa umur bayi yang paling dominan pada infeksi virus dengue adalah 4-9 bulan.…”

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Profil Manifestasi Klinis dan Laboratoris Pasien Dengue Bayi yang Menjalani Rawat Inap di RSUP. DR. Hasan Sadikin Bandung

Handayani¹,

Indrati²,

Alam³

2018

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Latar belakang. Dibanding pada anak dan dewasa, kejadian infeksi virus dengue pada bayi meningkat tiap tahun dengan derajat keparahan yang cepat. Jumlah penelitian mengenai manifestasi klinis maupun laboratoris pada pasien infeksi dengue bayi masih kurang terpublikasi. Tujuan. Untuk menggambarkan manifestasi klinis dan laboratoris pasien infeksi dengue bayi di RSUP DR.Hasan Sadikin tahun 2011-2016. Metode. Penelitian dengan desain observasional deskriptif kuantitatif. Data manifestasi klinis dan laboratoris diambil selama rawat inap. Hasil. Sampel 62 bayi, termuda berusia 2 bulan. Manifestasi terbanyak adalah ptekie, feses cair, hepatomegali, batuk pilek, muntah efusi pleura dan pendarahan intra abdomen. Dua pasien tidak mengalami demam. Saat nadir, trombositopenia terjadi pada 98,3% pasien. Rerata terendah hemoglobin 9,12 g/dL, hematokrit 26,7%, dan leukosit 8898 /mm 3 . Terjadi gangguan fungsi hati dari data peningkatan SGPT pada 62,9% pasien dan SGOT pada 88,8% pasien. Kesimpulan. Usia terbanyak adalah rentang umur 4-6 bulan dengan manifestasi paling sering adalah demam, beberapa pasien langsung mengalami manifestasi pendarahan tanpa mengalami demam. Pada EDS manifestasi paling sering yaitu kejang dan penurunan kesadaran. Mayoritas pasien memiliki kadar Hb rendah, trombositopenia dan abnormalitas fungsi hati. Sari Background. The incidence of dengue virus infection is increasing every year and the progression of the disease is faster towards severe manifestations in infants than in children and adults. The number of studies on clinical and laboratory manifestations in infant Dengue patients is still less published. Objective. This study is aimed to describe the clinical and laboratory manifestastions of infant dengue patients at RSUP. DR. Hasan Sadikin in Janurary 2011 -December 2016. Methods. This study used descriptive quantitative observational as its research design and collecting data of clinical and laboratory manifestations using medical record during hospitalization. Result. From the samples of 62 babies with the youngest were 2 months old. Most manifestations found were ptechie, diarrhea, hepatomegaly, cough and colds, vomit, pleural effusion and intraabdominal hemorrhage. Two patients had no fever. When nadir, thrombocytopenia occurs in 98.3% of patients. The lowest mean Hb: 9.12 g/dL, hematocrit: 26.7% and leukocytes: 8898 /mm 3 . Liver function impairment of SGPT increased in 62.9% of patients and SGOT in 88.8% of patients Conclusion. Most age is 4-6 months age range with the most frequent manifestation is fever, some patients directly experience bleeding manifestation without experiencing fever. In EDS most frequent manifestations are seizures and decreased consciousness. The majority of patients have low Hb levels, thrombocytopenia and liver function abnormalities.Sari Pediatri 2017;19(3):119-26

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Dengue infection

Cited by 529 publications

References 264 publications

Dissecting the human serum antibody response to secondary dengue virus infections

Dissecting the human serum antibody response to secondary dengue virus infections

Biochemistry and Molecular Biology of Flaviviruses

Profil Manifestasi Klinis dan Laboratoris Pasien Dengue Bayi yang Menjalani Rawat Inap di RSUP. DR. Hasan Sadikin Bandung

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