Dengue hemorrhagic fever

Sinniah, M; Igarashi, Akira

doi:10.1002/rmv.1980050403

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…Até os meados da década de 50, a dengue era considerada doença benigna, quando nas Filipinas (1953) surgiu o primeiro surto de dengue hemorrágica (FHD) 19 . Vinte e oito anos mais tarde aconteceu a primeira grande epidemia de FHD das Américas 2 .…”

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Aspectos clínicos e epidemiológicos da epidemia de dengue no Recife, PE, em 2002

Montenegro

Lacerda

Lira

et al. 2006

Rev. Soc. Bras. Med. Trop.

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RESUMO ABSTRACTThis paper shows data regarding dengue and hemorrhagic fever of the dengue epidemic in Recife in 2002 and the clinical, laboratorial and necropsy results from the 14 patients who died that year. The sorotype Den-3 was detected in 76.3% of cases. The majority of deaths occurred among men, over 20 years old, on the 11 th day of disease, attended in the private hospitals. The average values of the hematocryt and platelets were 40.7% and 56,313p/mm 3 , respectively. Hepatitis, with high levels of transaminases, occurred in the majority of patients, who generally were anicteric. Of the fourteen deaths, 13 received laboratorial confirmation of the infection. In eight cases death occurred due to hemorrhagic phenomena, however, in the other 6 cases significant bleeding was not identified. Vascular collapse (chock) was present in 12 (85.7%) cases, with or without the association of major bleeding, and was the most important cause of death.

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Aspectos clínicos e epidemiológicos da epidemia de dengue no Recife, PE, em 2002

Montenegro

Lacerda

Lira

et al. 2006

Rev. Soc. Bras. Med. Trop.

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“…Dengue viruses (DENs) are a group of mosquito-borne flaviviruses that cause public health problems worldwide, especially in tropical and subtropical areas (30,43). There are four antigenically related but distinct serotypes of DENs (DEN-1, DEN-2, DEN-3, and DEN-4) identified based on the plaque reduction neutralization test results (40).…”

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confidence: 99%

Study of Dengue Virus Infection in SCID Mice Engrafted with Human K562 Cells

Lin

Liao²,

Chen

et al. 1998

J Virol

166

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Here we report that severe combined immunodeficient (SCID) mice engrafted with human K562 cells (K562-SCID mice) can be used as an animal model to study dengue virus (DEN) infection. After intratumor injection into K562 cell masses of PL046, a Taiwanese DEN-2 human isolate, the K562-SCID mice showed neurological signs of paralysis and died at approximately 2 weeks postinfection. In addition to being detected in the tumor masses, high virus titers were detected in the peripheral blood and the brain tissues, indicating that DEN had replicated in the infected K562-SCID mice. In contrast, the SCID mice were resistant to DEN infection and the mock-infected K562-SCID mice survived for over 3 months. These data illustrate that DEN infection contributed directly to the deaths of the infected K562-SCID mice. Other serotypes of DEN were also used to infect the K562-SCID mice, and the mortality rates of the infected mice varied with different challenge strains, suggesting the existence of diverse degrees of virulence among DENs. To determine whether a neutralizing antibody against DEN in vitro was also protective in vivo, the K562-SCID mice were challenged with DEN-2 and received antibody administration at the same time or 1 day earlier. Our results revealed that the antibody-treated mice exhibited a reduction in mortality and a delay of paralysis onset after DEN infection. In contrast to K562-SCID, the persistently DEN-infected K562 cells generated in vitro invariably failed to be implanted in the mice. It seems that in the early stage of implantation, a gamma interferon activated, nitric oxide-mediated anti-DEN effect might play a role in the innate immunity against DEN-infected cells. The system described herein offers an opportunity to explore DEN replication in vivo and to test various antiviral protocols in infected hosts.

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