Dengue Fever Presenting with Hepatitis

Bowman, Seth; Salgado, Cassandra D.; DeWaay, Deborah

doi:10.1097/maj.0b013e318257c1db

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…This is in concordance with a study done by Prakash et al [21] in which 71 % had developed hepatitis. Elevated transaminases in DF are in concordance with a study done by Bowman et al [22]. Pulmonary complications in dengue, although rarely seen, include pulmonary infiltration and small pleural effusion.…”

Section: Discussionsupporting

confidence: 90%

Unusual and rare manifestations of dengue during a dengue outbreak in a tertiary care hospital in South India

et al. 2014

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Dengue is the most rapidly spreading mosquito-borne viral disease in the world, and as a larger proportion of the population is being affected, more unusual manifestations are being reported. Very few studies have documented unusual manifestations of dengue in South India. This prospective study was undertaken from July 2011 to June 2013 to document rare manifestations of dengue fever in 175 hospitalized patients. The clinical diagnosis was confirmed by the detection of NS1Ag, dengue IgM, or IgG by ELISA and/or a RT-PCR and CDC real-time PCR for dengue virus (DENV) RNA. The daily profiles of the hematological and biochemical investigations were followed and recorded. Unusual and rare manifestations of dengue were documented for 115 patients (66 %). Hepatitis was observed in 70 % of the cases. Pleural effusion was seen in 11 %, acute renal failure in 10 %, neurological complications such as encephalitis in 7.4 %, myocarditis in 9 %, and bleeding gastric ulcers in 3.4 % of the cases. DENV serotype 2 was more prevalent in patients with unusual manifestations of dengue in our study. The WHO classification system does not include unusual and rare manifestations; hence, it is essential to be aware of these manifestations and closely monitor them for better clinical management and outcome of patients.

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Section: Discussionsupporting

confidence: 90%

Unusual and rare manifestations of dengue during a dengue outbreak in a tertiary care hospital in South India

et al. 2014

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“…According to a study conducted on dengue patients in Vietnam, hepatic involvement is found in all patients with dengue and is in close correlation with disease severity [19]. According to Bowman et al, hepatic involvement in dengue is found more commonly in women, children or patients with a severe form of dengue [4]. Contrarily, we found hepatic involvement more commonly in male teenage patients without any critical form of DF.…”

Section: Discussionsupporting

confidence: 68%

“…This disease is also known as “breakbone fever” because of its classic presentation of influenza-like illness with spiking fevers, fatigue, retro-orbital pain, myalgia and headaches. The incubation period is typically 3-14 days [4]. Laboratory findings include thrombocytopenia, leukopenia, hyponatremia and hemoconcentration [5].…”

Section: Introductionmentioning

confidence: 99%

Acute Hepatitis in Infections Caused by Dengue Virus in Southern Punjab, Pakistan

Ishtiaq

Ali

Raza

et al. 2018

Cureus

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Background Dengue is the most common vector-borne disease worldwide. It poses a significant health burden in tropical and subtropical countries. Common clinical presentations include retro-orbital pain, fever, headache, nausea, vomiting and aches and pains in the body. A severe form of dengue fever is known as dengue hemorrhagic fever (DHF) that includes signs of hemorrhage. Besides the typical signs and symptoms, atypical presentations of dengue include myositis, hepatitis and encephalitis. Hepatic involvement in dengue has varied presentations. This study aims to highlight the importance of acute hepatitis, an atypical presentation in dengue patients. Methods We conducted a descriptive, cross-sectional study in the Medical Unit-1 of Bahawal Victoria Hospital, Bahawalpur, a tertiary-care hospital serving the area of Southern Punjab, Pakistan. The relevant medical records of 63 patients admitted with dengue-associated hepatitis to the Medical Unit-1 of Bahawal Victoria Hospital, Bahawalpur, between January 1, 2015 and December 1, 2016, were reviewed. Informed consent was given. Information regarding demographic variables and disease course was collected and analyzed. Results This study included 55 men (87.3%) and eight (12.7%) women. Fifty (79.3%) patients were diagnosed with dengue fever (DF). Thirteen patients were managed on the lines of DHF. Out of the total 63 patients, only six were locals. The common clinical presentations in these patients included high fever, retro-orbital pain, severe headache, rash, dark-colored urine, bleeding problems and hepatomegaly. Higher levels of aspartate aminotransferase (AST) were noted in comparison to alanine transferase (ALT). Despite the complicated clinical course in some patients, all patients were managed successfully and discharged, except one. Conclusion The frequency of acute hepatitis in dengue patients is high, especially in young men. Early diagnosis and prompt treatment are necessary for better prognosis. Although no specific treatment guidelines are available, supportive treatment in a timely fashion can prevent complications. Transfusion with packed cell volume (PCV) and N-acetyl cysteine (NAC) has produced promising results.

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“…Clinical symptomatology of dry cough for last 20 days, abdominalpain along with little air fluid level on abdominal x-ray needed more explanation and insight. Dengue often present with transaminitis but high level of enzymes is rare in classical dengue fever without shock 3,4 . Jaundice is also not frequently present in dengue fever.…”

Section: Discussionmentioning

confidence: 99%

Dengue Co-Infection Microfilaria Presenting with Intestinal Obstruction: A Case Report

Kumar¹,

Manchanda²,

Panda³

et al. 2018

J. Bangladesh Coll. Phys.

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In the recent years morbidity caused by dengue epidemic has been devastating. Confection of dengue malaria and filaria has been reported in literature where in filarial antigen was detected in the patient. Concurrent infection by dengue and filaria with high parsetemic microfilariae load in a single individual is very rarely known. The varied clinical profile in dengue is multifactorial and concurrent co-infection may be one of them. Here in this case of concurrent infection with dengue and filarial, the patient presented with intestinal obstruction which responded dramatically with diethylcarbamizine while other clinicalsyndrome took a long time. Furthermore, if single vector can harbour both the infectious agent, the etiopathogenesis may completely take a different turn and at times project alarming condition. J Bangladesh Coll Phys Surg 2019; 37(1): 35-38

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Dengue Fever Presenting with Hepatitis

Cited by 7 publications

References 8 publications

Unusual and rare manifestations of dengue during a dengue outbreak in a tertiary care hospital in South India

Unusual and rare manifestations of dengue during a dengue outbreak in a tertiary care hospital in South India

Acute Hepatitis in Infections Caused by Dengue Virus in Southern Punjab, Pakistan

Dengue Co-Infection Microfilaria Presenting with Intestinal Obstruction: A Case Report

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