Dengue fever on the rise in Southeast Asia

Alied, Marcel; Nguyen, Dang Trang; Aziz, Jeza Muhamad Abdul; Vinh, Dang Phuc; Huy, Nguyen Tien

doi:10.1080/20477724.2022.2116550

Cited by 4 publications

(3 citation statements)

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“…Half the world’s population is at risk of contracting dengue, including 1.3 billion people living in 10 dengue-endemic countries of the Southeast Asian region ( 3 ). From 2015 to 2019, dengue cases in the region increased by 46%, culminating in a major epidemic in 2019 that led to the highest number of annual global cases (>5.2 million) ever to be reported in the same year ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Antibodies to Aedes aegypti D7L salivary proteins as a new serological tool to estimate human exposure to Aedes mosquitoes

Chea,

Willen,

Nhek

et al. 2024

Front. Immunol.

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IntroductionAedes spp. are the most prolific mosquito vectors in the world. Found on every continent, they can effectively transmit various arboviruses, including the dengue virus which continues to cause outbreaks worldwide and is spreading into previously non-endemic areas. The lack of widely available dengue vaccines accentuates the importance of targeted vector control strategies to reduce the dengue burden. High-throughput tools to estimate human-mosquito contact and evaluate vector control interventions are lacking. We propose a novel serological tool that allows rapid screening of human cohorts for exposure to potentially infectious mosquitoes. MethodsWe tested 563 serum samples from a longitudinal pediatric cohort study previously conducted in Cambodia. Children enrolled in the study were dengue-naive at baseline and were followed biannually for dengue incidence for two years. We used Western blotting and enzyme-linked immunosorbent assays to identify immunogenic Aedes aegypti salivary proteins and measure total anti-Ae. aegypti IgG. ResultsWe found a correlation (rs=0.86) between IgG responses against AeD7L1 and AeD7L2 recombinant proteins and those to whole salivary gland homogenate. We observed seasonal fluctuations of AeD7L1+2 IgG responses and no cross-reactivity with Culex quinquefasciatus and Anopheles dirus mosquitoes. The baseline median AeD7L1+2 IgG responses for young children were higher in those who developed asymptomatic versus symptomatic dengue. DiscussionThe IgG response against AeD7L1+2 recombinant proteins is a highly sensitive and Aedes specific marker of human exposure to Aedes bites that can facilitate standardization of future serosurveys and epidemiological studies by its ability to provide a robust estimation of human-mosquito contact in a high-throughput fashion.

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Section: Introductionmentioning

confidence: 99%

Antibodies to Aedes aegypti D7L salivary proteins as a new serological tool to estimate human exposure to Aedes mosquitoes

Chea,

Willen,

Nhek

et al. 2024

Front. Immunol.

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“…The Coronavirus Disease 2019 (COVID-19) pandemic and its consequences have been extensively studied [4,5]. Following the pandemic, there has been a significant increase in the number of dengue cases and their severity, particularly among children, in many provinces in Southeast Asia, including Vietnam [6]. The reason behind this outbreak remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Dengue virus serotypes and related factors in children with dengue hemorrhagic fever in Southern Vietnam

Quang Tran,

Hung Pham,

Thi Ngoc Tran

et al. 2024

J Infect Dev Ctries

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Introduction: After the Coronavirus Disease 2019 pandemic, a high number of cases and severe dengue in children were reported in some provinces in the south of Vietnam. This study aimed to determine the distribution of dengue virus serotypes and their correlation with demographic factors, disease severity, clinical manifestations, and laboratory findings. Methodology: This study employed a cross-sectional design. Ninety-six dengue-infected children admitted to Can Tho Children's Hospital between October 2022 and March 2023 were included. Confirmation of dengue infection was achieved through the real-time polymerase chain reaction (RT-PCR). Results: Among the identified serotypes, DENV-2 accounted for the highest proportion (71.87%), followed by DENV-1 (23.96%), and DENV-4 (4.17%). DENV-3 was not detected. No significant demographic, disease severity, or laboratory differences were observed among the identified dengue serotypes. However, DENV-2 was associated with a higher occurrence of mucous membrane hemorrhages and gastrointestinal bleeding compared to other serotypes. Conclusions: Although DENV-2 was the most prevalent serotype responsible for dengue in children in southern Vietnam, it did not lead to more severe cases compared to other serotypes. This finding is crucial for evaluating the illness’s prognosis.

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“…Half the world’s population is at risk of contracting dengue, including 1.3 billion people living in ten dengue-endemic countries of the South-East Asian region (3). From 2015 to 2019, dengue cases in the region increased by 46% culminating in a major epidemic in 2019 that led to the highest number of annual global cases (>5.2 million) ever to be reported in the same year (4).…”

Section: Introductionmentioning

confidence: 99%

Antibodies toAedes aegyptiD7L salivary proteins as a new serological tool to estimate human exposure toAedesmosquitoes

Chea,

Willen,

Nhek

et al. 2023

Preprint

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1AbstractIntroductionAedes spp.are the most prolific mosquito vectors in the world. Found on every continent, they can effectively transmit various arboviruses, including the dengue virus which continues to cause outbreaks worldwide and is spreading into previously non-endemic areas. The lack of widely available dengue vaccines accentuates the importance of targeted vector control strategies to reduce the dengue burden. High-throughput sensitive tools to estimate human-mosquito contact and evaluate vector control interventions are lacking. We propose a novel serological tool that allows rapid screening of large human cohorts for exposure to potentially infectious mosquitoes and effective targeting of vector control.MethodsWe tested 563 serum samples from a longitudinal pediatric cohort study previously conducted in Cambodia. Children enrolled in the study were dengue-naïve at baseline and were followed biannually for dengue incidence for two years. We used Western blotting and enzyme-linked immunosorbent assays to identify the most immunogenicAedes aegyptisalivary proteins and measure total anti-Ae. AegyptiIgG.ResultsWe found a strong correlation (rs=0.86) between the combined IgG responses against AeD7L1 and AeD7L2 recombinant proteins and those to whole salivary gland homogenate. We observed seasonal fluctuations of AeD7L1+2 IgG responses, corresponding toAedes spp.abundance in the region, and no cross-reactivity withCulex quinquefasciatusandAnopheles dirusmosquitoes. The baseline median AeD7L1+2 IgG responses for young children were higher in those who developed asymptomatic dengue versus those who developed symptomatic dengue.ConclusionThe IgG response against AeD7L1+2 recombinant proteins is a highly sensitive andAedesspecific marker of human exposure toAedesbites that can facilitate standardization of future serosurveys and epidemiological studies by its ability to provide a robust estimation of human-mosquito contact in a high-throughput fashion.

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Dengue fever on the rise in Southeast Asia

Cited by 4 publications

References 0 publications

Antibodies to Aedes aegypti D7L salivary proteins as a new serological tool to estimate human exposure to Aedes mosquitoes

Antibodies to Aedes aegypti D7L salivary proteins as a new serological tool to estimate human exposure to Aedes mosquitoes

Dengue virus serotypes and related factors in children with dengue hemorrhagic fever in Southern Vietnam

Antibodies toAedes aegyptiD7L salivary proteins as a new serological tool to estimate human exposure toAedesmosquitoes

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