Dengue Fever as A Cause of Acute Disseminated Encephalomyelitis (ADEM)

Chowdhury, RN; Siddiqui,; Mahbub,; Hasan, Osi; Talukder, Abu Mohammad; Nabi, Sumaira; Miah, Tayaba

doi:10.3329/jom.v12i2.8428

Cited by 11 publications

(5 citation statements)

References 8 publications

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“…The outcomes in these cases were either death (3 cases), partial recovery (7 cases), complete recovery (16 cases) or ND (3 cases). The cases with partial recovery were either; had mild B/L visual disturbance, dysuria, and dyschezia remained [ 49 ], was able to walk with a minimal support [ 50 ], wanted to carry further treatment in the hospital [ 51 ], a slight residual cerebellar ataxia [ 52 ], the frontal symptoms persisted [ 53 ], mild ataxia and dysarthria [ 54 ]. The three cases died due to; myalgia, jaundice, conjunctival hemorrhage, hematuria, oliguria, shortness of breath, became stuporous, acute respiratory distress syndrome (ARDS), acute kidney injury and metabolic acidosis [ 55 ], intracranial tension [ 56 ] or B/L hemorrhagic demyelination [ 57 ] ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis

Kamel

Nam²,

Han

et al. 2017

PLoS Negl Trop Dis

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BackgroundDengue is one of the most common infectious diseases. The aim of this study was to systematically review acute disseminated encephalomyelitis (ADEM) and to represent a new case.Methodology/Principal findingsWe searched for articles in nine databases for case reports, series or previous reviews reporting ADEM cases in human. We used Fisher’s exact and Mann-Whitney U tests. Classification trees were used to find the predictors of the disease outcomes. We combined findings using fixed- and random-effects models. A 13-year-old girl was admitted to the hospital due to fever. She has a urinary retention. The neurological examinations revealed that she became lethargic and quadriplegic. She had upper limbs weakness and lower limbs complete paraplegia. Her status gradually improved after the treatment. She was nearly intact with the proximal part of her legs had a mild weakness in discharge. The prevalence of ADEM among dengue patients was 0.4% [95% confidence intervals (95% CI) 0.1–2.5%], all neurological disorders among dengue was 2.6% [95% CI 1.8–3.8%], and ADEM among neurological disorders was 6.8% [95% CI 3.4–13%]. The most frequent manifestation of ADEM was altered sensorium/consciousness (58%), seizures and urination problems (35%), vision problems (31%), slurred speech (23%), walk problems (15%) then ataxia (12%). There was a significant difference between cases having complete recovery or bad outcomes in the onset day of neurological manifestations being earlier and in temperature being higher in cases having bad outcomes (p-value < 0.05). This was confirmed by classification trees which included these two variables.Conclusions/SignificanceThe prevalence of ADEM among dengue and other dengue-related neurological disorders is not too rare. The high fever of ADEM cases at admission and earlier onset day of neurological manifestations are associated with the bad outcomes.

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Section: Resultsmentioning

confidence: 99%

Post-dengue acute disseminated encephalomyelitis: A case report and meta-analysis

Kamel

Nam²,

Han

et al. 2017

PLoS Negl Trop Dis

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“…Nervous system involvement is associated with serotypes 2 and 3. 1 Dengue infections are usually asymptomatic but can present with classic dengue fever, dengue hemorrhagic fever, or dengue shock syndrome. Some unusual manifestations of dengue infection that have been reported as a part of expanded dengue syndrome include liver failure, renal failure and neurological complications such as polyradiculoneuropathy, myelitis, encephalitis, and cranial nerve palsies.…”

Section: Introductionmentioning

confidence: 99%

Facial nerve palsy: An atypical presentation of dengue fever

Mukherjee

2023

Asian J Med Sci

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Dengue fever is a grave public health concern in tropical countries. The disease spectrum of dengue fever is multi-systemic, although neurologic complications of dengue fever is relatively uncommon. The pathogenesis of neurologic manifestations in dengue fever is not well understood and may be due to the neurotrophic effect of the virus, or related to the systemic effects of dengue infection, and immune mediated. Here in, we discuss the occurrence of isolated 7th cranial nerve lower motor neuron type palsy in a 23-year-old lady suffering from dengue fever. To date, there are very few case reports citing the involvement of facial nerve in dengue fever.

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“…Neurological manifestations are very rare and are caused by serotypes 2 and 3. 1 Encephalopathy, meningitis, acute pure motor weakness, mononeuropathies, transverse myelitis, stroke, acute disseminated encephalomyelitis, Guillain-Barre Syndrome, hypokalemic paralysis and neuromyelitis optica are the recognized neurological manifestations associated with dengue fever. 2 There were few cases of isolated facial nerve palsy in dengue haemorrhagic fever which had been reported in literature in Sri Lanka.…”

Section: Introductionmentioning

confidence: 99%