Dengue, chikungunya, and Zika virus infections imported to Paris between 2009 and 2016: Characteristics and correlation with outbreaks in the French overseas territories of Guadeloupe and Martinique

The spread of dengue through global human mobility is a major public health concern. A key challenge is understanding the transmission pathways and mediating factors that characterized the patterns of dengue importation into non-endemic areas. Utilizing a network connectivity-based approach, we analyze the importation patterns of dengue fever into European countries. Seven connectivity indices were developed to characterize the role of the air passenger traffic, seasonality, incidence rate, geographical proximity, epidemic vulnerability, and wealth of a source country, in facilitating the transport and importation of dengue fever. We used generalized linear mixed models (GLMMs) to examine the relationship between dengue importation and the connectivity indices while accounting for the air transport network structure. We also incorporated network autocorrelation within a GLMM framework to investigate the propensity of a European country to receive an imported case, by virtue of its position within the air transport network. The connectivity indices and dynamical processes of the air transport network were strong predictors of dengue importation in Europe. With more than 70% of the variation in dengue importation patterns explained. We found that transportation potential was higher for source countries with seasonal dengue activity, high passenger traffic, high incidence rates, high epidemic vulnerability, and in geographical proximity to a destination country in Europe. We also found that position of a European country within the air transport network was a strong predictor of the country's propensity to receive an imported case. Our findings provide evidence that the importation patterns of dengue into Europe can be largely explained by appropriately characterizing the heterogeneities of the source, and topology of the air transport network. This contributes to the foundational framework for building integrated predictive models for bio-surveillance of dengue importation.

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Section: Introductionmentioning

confidence: 99%

Dengue importation into Europe: A network connectivity-based approach

et al. 2020

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“…Thus, creating a mobility network for the spread of infectious diseases like dengue [9][10][11]. Infected air travelers have contributed significantly to the importation of dengue to non-endemic areas [12][13][14].As human mobility and connectivity continue to advance, dengue spread via importation will continue to increase at unpredictable rates [4, 15]. The complexity of the air transport network poses a substantial challenge in the understanding of the dynamics of dengue spread and importation [16, 17].…”

mentioning

confidence: 99%

Dengue importation into Europe: a network connectivity-based approach

Salami

Capinha

Martins

et al. 2019

Preprint

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The spread of dengue through global human mobility is a major public health concern. A key challenge is understanding the transmission pathways and mediating factors that characterized the patterns of dengue importation into non-endemic areas. Utilizing a network connectivity-based approach, we analyze the importation patterns of dengue fever into European countries. Seven connectivity indices were developed to characterize the role of the air passenger traffic, seasonality, incidence rate, geographical proximity, epidemic vulnerability, and wealth of a source country, in facilitating the transport and importation of dengue fever. We used generalized linear mixed models (GLMMs) to examine the relationship between dengue importation and the connectivity indices while accounting for the air transport network structure. We also incorporated network autocorrelation within a GLMM framework to investigate the propensity of a European country to receive an imported case, by virtue of its position within the air transport network. The connectivity indices and dynamical processes of the air transport network were strong predictors of dengue importation in Europe. With more than 70% of the variation in dengue importation patterns explained. We found that transportation potential was higher for source countries with seasonal dengue activity, high passenger traffic, high incidence rates, lower economic status, and geographical proximity to a destination country in Europe. We also found that position of a European country within the air transport network was a strong predictor of the country′ propensity to receive an imported case. Our findings provide evidence that the importation patterns of dengue into Europe can be largely explained by appropriately characterizing the heterogeneities of the source, and topology of the air transport network. This contributes to the foundational framework for building integrated predictive models for bio-surveillance of dengue importation.

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“…Other causes of febrile illness such as dengue and Zika virus infection, malaria and typhoid fever should also be considered depending on the disease prevalence in the visited country. 2,3 Blood investigations in the initial stages can show transient anaemia, leukopenia, lymphopenia, mild thrombocytopenia, raised liver enzymes and serum creatinine levels. 15,34 Chikungunya virus can be detected by the reverse transcription (RT) -PCR method from 0 to 7 days of infection, after which PCR detection becomes unreliable.…”

Section: Diagnosismentioning

confidence: 99%

“…1 The global spread of CHIKV infection is shown in Fig 1 . In a returning traveller presenting with fever, skin rash and arthralgia, CHIKV infection is emerging as an important differential diagnosis along with other arboviral infections such as dengue and Zika. 2,3 This vector born disease is transmitted to humans by the bite of infected female Aedes aegypti (predominantly in tropical countries) or Aedes albopictus ( predominantly in temperate countries) mosquitoes. Other species of mosquitoes, like Culex and Anopheles stephensi, have been shown experimentally to support ABSTRACT transmission of CHIKV.…”

Section: Introductionmentioning

confidence: 99%

Chikungunya arthritis

Pathak¹,

Mohan²,

Ravindran³

2019

Clinical Medicine

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The chikungunya virus (CHIKV) infection epidemic has emerged as a significant public health concern in the last 10-15 years, especially in Asian and south American countries. However, with ever-expanding tourism and migration, cases have now been reported in north America and Europe. CHIKV infection predominantly causes musculoskeletal symptoms with a chronic polyarthritis which may resemble autoimmune inflammatory arthritis. CHIKV infection should always be suspected in a returning traveller presenting with fever, skin rash and arthralgia. Though first reported in the last century, a series of epidemics since 2004 have substantially improved our knowledge. There has also been a significant increase in our understanding of the immunopathogenesis of chikungunya infection. This knowledge is being used in the development of new treatment strategies and preventive measures. In this narrative review, we discuss some of the recent advances in the epidemiology, immunopathogenesis, and management of CHIKV arthritis.

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Dengue, chikungunya, and Zika virus infections imported to Paris between 2009 and 2016: Characteristics and correlation with outbreaks in the French overseas territories of Guadeloupe and Martinique

Cited by 25 publications

References 15 publications

Dengue importation into Europe: A network connectivity-based approach

Dengue importation into Europe: A network connectivity-based approach

Dengue importation into Europe: a network connectivity-based approach

Chikungunya arthritis

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