Dengue-Associated Acute Kidney Infection: An Updated and Comprehensive Qualitative Review of Literature

Abstract

Dengue is a viral infection transmitted by an Aedes aegypti mosquito bite that poses a major threat to public health worldwide. While acute kidney injury secondary to dengue infection is a potentially lethal complication, it remains one of the least studied complications of dengue fever. The underlying mechanism of dengue-associated acute kidney injury is complex because it involves multiple pathways that could independently lead to its occurrence. Therefore, the cornerstone of dengue-associated acute kidney injury management should involve prompt recognition and identification of the at-risk population and administration of appropriate supportive treatment in a timely manner with the aim of preventing both renal and non-renal morbidity and mortality.

Prevalence, Characteristics, and Outcomes Associated with Acute Kidney Injury among Adult Patients with Severe Dengue in Mainland China

“…The pathogenesis of dengue-associated AKI is unclear and may be complex, caused by the direct action of the virus, immune mechanisms, hemolysis, rhabdomyolysis, or shock. 33 One of the most controversial mechanisms is the direct action of viruses. Some studies have detected viral antigens or loads in the renal tissue pathology of patients with DENV infection.…”