Dengue and Scrub Typhus Coinfection in a Patient Presenting with Febrile Illness

Sapkota, Surendra; Bhandari, Sudeep; Hamal, Rabin

doi:10.1155/2017/6214083

Cited by 21 publications

(22 citation statements)

References 4 publications

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“…In the present study, we found seven leptospirosis patients to be co-infected with dengue and one with scrub typhus. Leptospirosis co-infection with dengue or scrub typhus is commonly seen in neighbouring countries such as Thailand and India [36][37][38][39][40][41][42][43]. Dengue is highly endemic in Malaysia with a minimum of 100,000 cases and more than 200 mortalities every year [44].…”

Section: Discussionmentioning

confidence: 99%

Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia

et al. 2020

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Background Leptospirosis, commonly known as rat-urine disease, is a global but endemic zoonotic disease in the tropics. Despite the historical report of leptospirosis in Malaysia, the information on human-infecting species is limited. Determining the circulating species is important to understand its epidemiology, thereby to strategize appropriate control measures through public health interventions, diagnostics, therapeutics and vaccine development. Methodology/Principle findings We investigated the human-infecting Leptospira species in blood and serum samples collected from clinically suspected leptospirosis patients admitted to three tertiary care hospitals in Malaysia. From a total of 165 patients, 92 (56%) were confirmed cases of leptospirosis through Microscopic Agglutination Test (MAT) (n = 43; 47%), Polymerase Chain Reaction (PCR) (n = 63; 68%) or both MAT and PCR (n = 14; 15%). The infecting Leptospira spp., determined by partial 16S rDNA (rrs) gene sequencing revealed two pathogenic species namely Leptospira interrogans (n = 44, 70%) and Leptospira kirschneri (n = 17, 27%) and one intermediate species Leptospira wolffii (n = 2, 3%). Multilocus sequence typing (MLST) identified an isolate of L. interrogans as a novel sequence type (ST 265),

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Section: Discussionmentioning

confidence: 99%

Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia

et al. 2020

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“…Both these diseases peak during the monsoon and share common demographic and clinical features. Despite similarities, coinfections are exceedingly rare [8,9]. Whether this is because of the different vectors involved, a low index of suspicion or a lack of diagnostics remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Dengue with Scrub Typhus Coinfection in Northern India

Singh

Mishra²,

Agarwal

et al. 2020

IJTDH

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Background: Amongst the many vector and water-borne diseases prevalent in tropics, dengue occupies a prominent place. Dengue epidemics are frequent and at times, during such epidemic, coinfections may occur causing diagnostic dilemmas. Case Report: A 36 years old lady, from a rural background, presented during the 2019 dengue epidemic with fever, vomiting, and non-colicky abdominal pain. The evaluation showed hepatosplenomegaly, leukocytosis, and thrombocytopenia. The investigations confirmed the diagnosis and she was treated conservatively as a case of dengue with warning signs. A longer than anticipated duration of fever and clinical deterioration prompted reassessment, which revealed the presence of an eschar over the right upper thigh. The Weil-Felix test using Proteus OX-K stain was positive at a titer of 1:320. Following treatment with oral doxycycline, she showed rapid defervescence and clinical improvement. Conclusions: Coinfection with scrub typhus is rare with dengue. If left untreated, it adversely affects the outcome. The key to diagnosing such coinfections includes a high index of suspicion, repeated clinical examination, and the knowledge of local endemicity.

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“…A recent case report from Nepal described coinfection of dengue and scrub typhus. 16 For this case, diagnosis of dengue was made early, with investigation for scrub typhus only considered in view of persistent symptoms. Enzyme-linked immunosorbent assay for scrub typhus returned positive, and by that time the patient had already been empirically commenced on doxycycline with a high clinical suspicion for scrub typhus infection in a known endemic area.…”

Section: Discussionmentioning

confidence: 99%

Typhoid and Scrub Typhus Coinfection in a Returned Traveler

Seow

Logarajah

Tan

2017

Global Pediatric Health

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This is a case report of a 12-year-old returned traveler with typhoid and scrub typhus coinfection. The diagnosis of typhoid was made early with blood cultures and Widal Weil Felix serology. Persistent fever despite appropriate antibiotics for typhoid fever prompted a search for concomitant infection, which led to the diagnosis of scrub typhus confirmed by Orientia tsutsugamushi serology. The patient was given doxycycline with good clinical response. Scrub typhus infection should be an early consideration in the differential diagnoses of fever in a returned traveler from regions where it is endemic. Coinfections should be taken into consideration particularly when fever or symptoms persist despite adequate therapy for a previously identified microorganism.

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Dengue and Scrub Typhus Coinfection in a Patient Presenting with Febrile Illness

Cited by 21 publications

References 4 publications

Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia

Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia

Dengue with Scrub Typhus Coinfection in Northern India

Typhoid and Scrub Typhus Coinfection in a Returned Traveler

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