Denervation of the renal arteries — what next?

Kostka-Jeziorny, Katarzyna; Tykarski, Andrzej; Grajek, Stefan

doi:10.5603/kp.a2016.0146

Cited by 1 publication

(1 citation statement)

References 19 publications

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“…Nowadays autonomic imbalance has been identified as an important aetiological factor contributing to the occurrence and progression of cardiovascular diseases such as hypertension (HT) and heart failure (HF) [7][8][9][10][11][12][13]. This finding resulted in the development of pharmacological and non-pharmacological methods for restoring the autonomic balance, including renal denervation, baroreceptor stimulation, and vagal nerve stimulation as well as the concept of CBD [5,10,13,14].…”

Section: Introductionmentioning

confidence: 99%

Human carotid bodies as a therapeutic target: new insights from a clinician’s perspective

Tubek¹,

Niewiński²,

Paleczny³

et al. 2018

Kardiol Pol

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From the physiological point of view, carotid bodies are mainly responsible for the ventilatory response to hypoxia; however, they also take part in the regulation of sympathetic tone. According to preclinical data, these structures likely contribute to the development and progression of sympathetically mediated diseases. Moreover, carotid body deactivation in animal models improved blood pressure control in hypertension and reduced mortality in heart failure, along with reducing sympathetic activity. On this basis, two first-in-man studies have been recently performed to investigate the safety and feasibility of such an approach in humans. In this review we summarise the current knowledge regarding the function of carotid bodies, the prevalence of their abnormalities, and the consequences of their excision in human hypertension and heart failure.

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