Denervation as a Method to Produce a Prolonged Stimulation of Salivary Glands

Emmelin, N.

doi:10.1016/b978-0-08-027349-5.50007-0

Cited by 6 publications

(5 citation statements)

References 33 publications

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“…Firstly, secretion starts almost immediately postoperatively and lasts for approximately 1 week; this can be attributed to release of neurotransmitters from degenerating postganglionic axons at neuroeffector terminals (17). Subsequent cessation of flow for several months coincides with gross reduction in transmitter release leading to parenchymal atrophy and the development of hypersensitivity to humoral agents, despite the atrophy.…”

Section: Discussionmentioning

confidence: 99%

Innervation and Secretory Function of Transplanted Human Submandibular Salivary Glands

Geerling

Garrett²,

Kl³

et al. 2008

Transplantation

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Free submandibular gland autotransplantation is used to treat absolute tear deficiency. Although disconnected from any peripheral innervation, most transplants show increasing secretion for years. We have evaluated the secretory activity and autonomic innervation of such transplants. Secretory activity of glands in response to parasympatholytics and parasympathomimetics was evaluated by Schirmer's test and Technetium scintigraphy. Submandibular gland tissue specimens taken before and after transplantation were examined histologically. Relative hypersecretion during the first postoperative week suddenly decreased but then slowly increased during the first postoperative year. Hypersecretion was significantly reduced by parasympatholytics while carbachol rapidly increased secretion. Histology of transplanted glandular tissue showed parenchymal atrophy. Cholinesterase-positive nerves were abundant and in a similar distribution to normal with scattered positive ganglion cells. Adrenergic axons were fewer than normal and irregularly distributed. Early hypersecretion may be due to release of neurotransmitters from degenerating terminal axons. This is followed by a period of minimal secretion during which hypersensitivity of acinar cells develops. With spontaneous reinnervation, secretion is accentuated by external sympathetic vasomotor adrenergic drive. This shows that submandibular glands can remain viable despite complete separation from their normal nerve supply and are capable of regaining a substantial secretory activity for years.

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Section: Discussionmentioning

confidence: 99%

Innervation and Secretory Function of Transplanted Human Submandibular Salivary Glands

Geerling

Garrett²,

Kl³

et al. 2008

Transplantation

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“…During degeneration of post-ganglionic nerves there is a period of increased liberation of neurotransmitter, which is usually sufficient to activate temporarily the effector cells, causing 'degeneration activity' (see Emmelin & Trendelenburg, 1972). This phenomenon has been demonstrated in salivary glands of many species (Emmelin, 1981), but so far only the secretion offluid has been investigated. The present experiments deal with 'degeneration secretion' ofamylase from the parotid gland of the rat after parasympathetic or sympathetic denervation.…”

Section: Introductionmentioning

confidence: 93%

Degeneration Secretion of Amylase From the Parotid Gland of the Rat

1982

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In anaesthetized rats the parotid saliva secreted during degeneration of the auriculo-temporal nerve contains amylase in fairly constant concentration, the amylase output varying with the secretory rate. The amount of amylase was not reduced by adrenoceptor blocking agents; it was increased by sympathectomy carried out one week in advance. A sympathetic degeneration secretion of amylase could also be demonstrated while the post-ganglionic sympathetic nerves were degenerating; a simultaneous parasympathetic degeneration secretion provided the salivary flow needed for the transport of the amylase.

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“…The time scale is similar to that seen when removal of the superior cervical ganglion in the rat causes salivation from the submandibular gland (Delfs & Emmelin, 1974) and contraction of the periorbital smooth muscles (Lundberg, 1970). The phenomenon has the characteristics of a 'degeneration secretion' (see Emmelin, 1981), which can thus be demonstrated in an in vitro preparation and further analysed there.…”

Section: Discussionmentioning

confidence: 60%

PAROTID DEGENERATION SECRETION OF AMYLASE IN VITRO IN THE RAT FOLLOWING SYMPATHECTOMY

et al. 1982

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After extirpation of the superior cervical ganglion in the rat a degeneration secretion of amylase occurs in an in vitro preparation of the parotid gland. It can be detected about 14 h after the sympathectomy, reaches a maximum after about 17 h and then slowly subsides. It is abolished by atenolol, but not by dihydroergotamine or atropine, nor by tetrodotoxin. From this it is concluded that the phenomenon is due to an action mainly on β1‐adrenoceptors exerted by noradrenaline, which is released from the degenerating sympathetic nerves at the neuro‐glandular junctions, independently of propagated nerve impulses.

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Denervation as a Method to Produce a Prolonged Stimulation of Salivary Glands

Cited by 6 publications

References 33 publications

Innervation and Secretory Function of Transplanted Human Submandibular Salivary Glands

Innervation and Secretory Function of Transplanted Human Submandibular Salivary Glands

Degeneration Secretion of Amylase From the Parotid Gland of the Rat

PAROTID DEGENERATION SECRETION OF AMYLASE IN VITRO IN THE RAT FOLLOWING SYMPATHECTOMY

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