Dendrosomal nanocurcumin and exogenous p53 can act synergistically to elicit anticancer effects on breast cancer cells

Baghi, Narges; Bakhshinejad, Babak; Keshavarz, Reihaneh; Babashah, Sadegh; Sadeghizadeh, Majid

doi:10.1016/j.gene.2018.05.025

Cited by 14 publications

(9 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nano curcumin was purchased from Alborz Nano-drug Technology Company from Iran. For in vitro experiments, DNC was diluted in complete culture medium (DMEM) at different concentrations (0.25–10 μM) using an optimized protocol which has been set up in our lab [ 20 – 22 , 42 ]. In Brief, different weight/weight ratios of dendrosome/curcumin were analyzed leading to the establishment of an appropriate ratio of 25:1.…”

Section: Methodsmentioning

confidence: 99%

“…However, the inherent limitations of the compound itself, such as hydrophobicity, instability, poor absorption and rapid systemic elimination, imposes a hurdle for translation to wider clinical applications [ 18 , 19 ]. To overcome this major barrier and enhancing half-life and cellular permeability of curcumin, we employed an amphipathic and biodegradable nanocarrier which was previously synthesized by our group called dendrosomal nanocurcumin (DNC) [ 20 – 22 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-β, VEGF, TNF-α and IL-6 expressions involved in wound healing process

et al. 2021

Self Cite

View full text Add to dashboard Cite

Introduction Pressure ulcer (PU) is known as the third most costly disorder usually caused by prolonged pressure and stagnation in various parts of the body. Although several therapeutic approaches are employing, obstacles in appropriate healing for skin lesions still exist which necessitates new practical alternative or adjunctive treatments. Low level laser therapy (LLLT) as one of the mentioned new strategies have gained attention. Besides, curcumin is an herbal medicine extracted from turmeric with anti-inflammatory and antioxidative properties with promising beneficial therapeutic effects in wound healing. Employing dendrosomal nanoparticles, we overcome the hydrophobicity of curcumin in the present study. We hypothesized that combination treatment of DNC+LLLT (450 nm) simultaneously may promote the wound healing process. Material and methods MTT assay, PI staining followed by flowcytometry, scratch assay and intracellular ROS measurement were used to investigate the effects caused by DNC and LLLT (450 nm) alone and in combination, on proliferation, cell cycle, migration and oxidative stress mouse embryonic fibroblast cells, respectively. The levels of growth factors and pro-inflammatory cytokines were evaluated by qRT-PCR and ELISA. Results Our results indicated that combination exposure with DNC and LLLT leads to increased proliferation and migration of MEFs as well as being more efficient in significantly upregulating growth factors (TGF-β, VEGF) and decline in inflammatory cytokines (TNF-α, IL-6). Moreover, findings of this research provide persuasive support for the notion that DNC could reduce the LLLT-induced enhancement in intracellular ROS in mouse embryonic fibroblasts. Conclusion Concurrent exposure to anti-oxidant concentrations of DNC and LLLT enriched S phase entry and therefor increased proliferation as well as migration on MEFs through regulating the expression levels growth factors and shortening the inflammatory phase by modulating of cytokines. It should be noted that DNC were able to reduce the laser-induced oxidative stress, during wound healing, representing an informative accompaniment with LLLT.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-β, VEGF, TNF-α and IL-6 expressions involved in wound healing process

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Triple-negative breast cancer (TNBC) is one of the most important histological subtypes of breast cancers having a metastatic phenotype. It has been demonstrated that dendrosomal nanocurcumin and exogenous p53 can act together to produce anticancer effects against TNBC cells (Baghi et al, 2018). HIF-1 and NF-kB are both indispensable for the improvement of cancer cell progression.…”

Section: Anticancer Effectsmentioning

confidence: 99%

Nanocurcumin: A Promising Candidate for Therapeutic Applications

2020

View full text Add to dashboard Cite

“…Besides translation factors, downstream of HIF-1α, curcumin markedly affects the expression of EMT TFs such as Twist (Kim et al, 2013), and Snail (Lee et al, 2015). Finally, Bagui et al (2018) reported that triple-negative breast cancer cells, which exhibited aberrant activity of EMT, were characterized by their reduced expression of zinc finger E-box-binding homeobox 1 (ZEB1) after treatment with a nanoformulation of curcumin (Figure 3).…”

Section: Molecular and Cellular Cancer Emt: Targets Of Curcuminoidsmentioning

confidence: 98%

Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies

et al. 2022

View full text Add to dashboard Cite

Curcuminoids, which include natural acyclic diarylheptanoids and the synthetic analogs of curcumin, have considerable potential for fighting against all the characteristics of invasive cancers. The epithelial-to-mesenchymal transition (EMT) is a fundamental process for embryonic morphogenesis, however, the last decade has confirmed it orchestrates many features of cancer invasiveness, such as tumor cell stemness, metabolic rewiring, and drug resistance. A wealth of studies has revealed EMT in cancer is in fact driven by an increasing number of parameters, and thus understanding its complexity has now become a cornerstone for defining future therapeutic strategies dealing with cancer progression and metastasis. A specificity of curcuminoids is their ability to target multiple molecular targets, modulate several signaling pathways, modify tumor microenvironments and enhance the host’s immune response. Although the effects of curcumin on these various parameters have been the subject of many reviews, the role of curcuminoids against EMT in the context of cancer have never been reviewed so far. This review first provides an updated overview of all EMT drivers, including signaling pathways, transcription factors, non-coding RNAs (ncRNAs) and tumor microenvironment components, with a special focus on the most recent findings. Secondly, for each of these drivers the effects of curcumin/curcuminoids on specific molecular targets are analyzed. Finally, we address some common findings observed between data reported in the literature and the results of investigations we conducted on experimental malignant mesothelioma, a model of invasive cancer representing a useful tool for studies on EMT and cancer.

show abstract

Dendrosomal nanocurcumin and exogenous p53 can act synergistically to elicit anticancer effects on breast cancer cells

Cited by 14 publications

References 69 publications

Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-β, VEGF, TNF-α and IL-6 expressions involved in wound healing process

Combination treatment of dendrosomal nanocurcumin and low-level laser therapy develops proliferation and migration of mouse embryonic fibroblasts and alter TGF-β, VEGF, TNF-α and IL-6 expressions involved in wound healing process

Nanocurcumin: A Promising Candidate for Therapeutic Applications

Curcuminoids as Modulators of EMT in Invasive Cancers: A Review of Molecular Targets With the Contribution of Malignant Mesothelioma Studies

Contact Info

Product

Resources

About