Dendronization: A practical strategy to improve the performance of molecular systems used in biomedical applications

Click synthesis of dendronized malonates for the preparation of amphiphilic dendro[60]fullerenes

“…In this regard, dendronization has been used as a practical strategy to induce amphiphilicity for micelle formation, thus enhancing the aqueous solubility and stability of several organic molecules as well as materials. 40 Dendrons are the branched sections of dendrimers which maintain the structural information programmed into these polymeric architectures including the controlled multivalency, monodispersity, globularity, and solubility in a wide range of solvents. [30][31][32][33][34][35][36][37][38][39][40][41][42][43] Polyester dendrimers and dendrons derived from 2,2′-bis(hydroxymethyl)propionic acid (bis-MPA) have gained singular attention related to their high aqueous solubility because of their hydroxyl groups in the periphery, that in turn, induced biocompatibility, and hydrolytic degradability.…”

“…40 Dendrons are the branched sections of dendrimers which maintain the structural information programmed into these polymeric architectures including the controlled multivalency, monodispersity, globularity, and solubility in a wide range of solvents. [30][31][32][33][34][35][36][37][38][39][40][41][42][43] Polyester dendrimers and dendrons derived from 2,2′-bis(hydroxymethyl)propionic acid (bis-MPA) have gained singular attention related to their high aqueous solubility because of their hydroxyl groups in the periphery, that in turn, induced biocompatibility, and hydrolytic degradability. 44,45 These dendrons have used to enhance the aqueous solubility of curcumin by ester linkage 46,47 or by click chemistry.…”

“…In this regard, dendronization has been used as a practical strategy to induce amphiphilicity for micelle formation, thus enhancing the aqueous solubility and stability of several organic molecules as well as materials. 40…”

Click synthesis of novel dendronized curcumin and analogs. Strengthening of physicochemical properties toward biological applications

“…3 The achieved increase of solubility can also favorably impact the photophysical properties of chromophore organic molecules, either by the generation of dendritic microenvironments suitable for the chromophore 4 or by the sterically imposed conformations that prevent the aggregation, 5 thus avoiding the emission quenching. 6…”

“…3 The achieved increase of solubility can also favorably impact the photophysical properties of chromophore organic molecules, either by the generation of dendritic microenvironments suitable for the chromophore 4 or by the sterically imposed conformations that prevent the aggregation, 5 thus avoiding the emission quenching. 6 Among dendron chemical motifs, the polyester dendrons derived from 2,2′-bis(hydroxymethyl)propionic acid (Bis-MPA) have gained singular attention due to their high aqueous solubility, biocompatibility, and hydrolytic degradability. 7 Polyester dendrons have been used to overcome the lability and poor aqueous solubility of hydrophobic molecules like curcumin, 8,9 which is a naturally occurring bioactive molecule with high therapeutic potential.…”