Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer

Bartel, Dianna L.; Rela, Lorena; Hsieh, Lawrence S.; Greer, Charles A.

doi:10.1002/cne.23714

Cited by 34 publications

(38 citation statements)

References 82 publications

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“…In contrast, we found no evidence that GCs concentrate their GABAergic output to specific subregions of the MC/TC lateral dendrite (e.g., near-somatic versus distal) in contrast to a previous report (Bartel et al, 2015), and we found no difference in dynamics in different compartments. Nonetheless, our spatially restricted analysis cannot rule out higher-order patterning of turnover, such as clustered turnover dynamics and intermittent turnover at the same location, as described in mouse cortex (Chen et al, 2012; Villa et al, 2016).…”

Section: Discussioncontrasting

confidence: 99%

Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb

Sailor

Valley

Wiechert

et al. 2016

Neuron

111

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SUMMARY In the mammalian brain, the anatomical structure of neural circuits changes little during adulthood. As a result, adult learning and memory are thought to result from specific changes in synaptic strength. A possible exception is the olfactory bulb (OB), where activity guides interneuron turnover throughout adulthood. These adult-born granule cell (GC) interneurons form new GABAergic synapses that have little synaptic strength plasticity. In the face of persistent neuronal and synaptic turnover, how does the OB balance flexibility, as is required for adapting to changing sensory environments, with perceptual stability? Here we show that high dendritic spine turnover is a universal feature of GCs, regardless of their developmental origin and age. We find matching dynamics among postsynaptic sites on the principal neurons receiving the new synaptic inputs. We further demonstrate in silico that this coordinated structural plasticity is consistent with stable, yet flexible, decorrelated sensory representations. Together, our study reveals that persistent, coordinated synaptic structural plasticity between interneurons and principal neurons is a major mode of functional plasticity in the OB.

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Section: Discussioncontrasting

confidence: 99%

Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb

Sailor

Valley

Wiechert

et al. 2016

Neuron

111

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“…; Isaacson and Strowbridge, ; Bartel et al . ). However, defining excitatory dendrodendritic synapses as reciprocal is difficult because vesicles are not clustered around discrete active zones and, instead, are dispersed along the dendrite (Pinching and Powell, a ).…”

Section: Discussionmentioning

confidence: 97%

“…) mice were on a mixed C57Bl6/CBA background, which did not alter the physiological or morphological properties of neurons within the olfactory bulb (Bartel et al . ). Thus, experiments from both genetic backgrounds were grouped, where appropriate.…”

Section: Methodsmentioning

confidence: 97%

Parallel processing of afferent olfactory sensory information

Vaaga

Westbrook

2016

The Journal of Physiology

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Primary olfactory receptor neurons terminate in anatomically and functionally discrete cortical modules known as olfactory bulb glomeruli. The synaptic connectivity and postsynaptic responses of mitral and external tufted cells within the glomerulus may involve both direct and indirect components. For example, it has been suggested that sensory input to mitral cells is indirect through feedforward excitation from external tufted cells. We also observed feedforward excitation of mitral cells with weak stimulation of the olfactory nerve layer; however, focal stimulation of an axon bundle entering an individual glomerulus revealed that mitral cells receive monosynaptic afferent inputs. Although external tufted cells had a 4.1-fold larger peak EPSC amplitude, integration of the evoked currents showed that the synaptic charge was 5-fold larger in mitral cells, reflecting the prolonged response in mitral cells. Presynaptic afferents onto mitral and external tufted cells had similar quantal amplitude and release probability, suggesting that the larger peak EPSC in external tufted cells was the result of more synaptic contacts. The results of the present study indicate that the monosynaptic afferent input to mitral cells depends on the strength of odorant stimulation. The enhanced spiking that we observed in response to brief afferent input provides a mechanism for amplifying sensory information and contrasts with the transient response in external tufted cells. These parallel input paths may have discrete functions in processing olfactory sensory input.

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“…Lateral inhibition in olfaction has been described in previous studies [8] [9] [57] [58] [59] [60]. Similar to amplification of tactile sensations of the integumentary system, smell is enhanced by lateral inhibition.…”

Section: Lateral Inhibition In Olfactionmentioning

confidence: 75%

Sensory Consciousness is Experienced through Amplification of Sensory Stimuli via Lateral Inhibition

Jerath¹,

Cearley²,

Paladiya³

et al. 2017

WJNS

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At present, researchers are unclear about which activity within the brain is responsible for the emergence of consciousness-the subconscious or unconscious. Current literature suggests that consciousness is isolated in the brain; however, we suggest consciousness emerges from both-subconscious and unconscious activity, in addition to sensory consciousness. This article contends that sensory consciousness arises from neurophysiological brain activity, intrapersonal space, sensory information, and parallel processing of the external and internal environment through vision, olfaction, the integumentary system, gustation, and audition. Traditionally, lateral inhibition is defined as the ability for an excited neuron to laterally inhibit its neighbors, and is an integral part of neurophysiology in all senses. In this article, we are connecting the science behind the well-established physiological observations of gamma wave activity in the interneurons of peripheral receptors with what is currently unknown regarding the functional significance of seemingly unrelated gamma activity in the cortico-thalamic gamma oscillations. We suggest that this allows for instantaneous integration of the brain with sensory receptors. This article uses existing literature on lateral inhibition to investigate its role in sensory organs and various areas of the body. We explain how sensory consciousness is only one component of unified consciousness. We propose that lateral inhibition also plays a vital role in consciousness theory, and understanding this can help illustrate the dynamic interactions between the central and peripheral nervous systems within the body.

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Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer

Cited by 34 publications

References 82 publications

Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb

Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb

Parallel processing of afferent olfactory sensory information

Sensory Consciousness is Experienced through Amplification of Sensory Stimuli via Lateral Inhibition

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