Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity

Lv, Ling-Li; Liu, Bo; Liu, Jing; Liu, Lisheng; Jin, Feng; Xu, Yun-Yan; Wu, Qin; Liu, Jie; Shi, Jing‐Shan

doi:10.3233/jad-200308

Cited by 32 publications

(27 citation statements)

References 48 publications

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“…Furthermore, metformin inhibited oxidative stress, improved mitochondrial viability, reduced inflammation and improved synaptic function in several cell and animal models of PD and AD [ 137 – 141 ]. By reducing Αβ secretion and tau phosphorylation, it improved behavioural outcomes such as cognitive performance in several transgenic animal models of AD [ 129 , 132 , 142 – 144 ]. However, a study in a mouse model of tauopathy (ApoE−/−) reported an increase of Αβ formation and tau phosphorylation with metformin [ 145 ].…”

Section: Resultsmentioning

confidence: 99%

RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus

O’Brien

Chouliaras²,

Sultana³

et al. 2022

Alz Res Therapy

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Drug repositioning and repurposing has proved useful in identifying new treatments for many diseases, which can then rapidly be brought into clinical practice. Currently, there are few effective pharmacological treatments for Lewy body dementia (which includes both dementia with Lewy bodies and Parkinson’s disease dementia) apart from cholinesterase inhibitors. We reviewed several promising compounds that might potentially be disease-modifying agents for Lewy body dementia and then undertook an International Delphi consensus study to prioritise compounds. We identified ambroxol as the top ranked agent for repurposing and identified a further six agents from the classes of tyrosine kinase inhibitors, GLP-1 receptor agonists, and angiotensin receptor blockers that were rated by the majority of our expert panel as justifying a clinical trial. It would now be timely to take forward all these compounds to Phase II or III clinical trials in Lewy body dementia.

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Section: Resultsmentioning

confidence: 99%

RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus

O’Brien

Chouliaras²,

Sultana³

et al. 2022

Alz Res Therapy

View full text Add to dashboard Cite

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“…Previous phytochemical investigations on D. nobile indicated that diversified compounds, including sesquiterpene glycosides, alkaloids, bibenzyls, plysaccharides and phenanthrenes have been isolated from this plant (Lam et al, 2015;Thanh et al, 2017;Wang et al, 2019;Xu et al, 2013;Xu et al, 2017). Among them, protecting the nervous system, regulating lipid metabolism has been closely related to alkaloids (Huang et al, 2019;Lv et al, 2020). However, for the effect of anti-immune activity, sesquiterpene glycosides were found to stimulate the proliferation of the proliferation of B cells in vitro (Lu et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Identification of sesquiterpene glycosides from Dendrobium nobile and their α-glycosidase and α-amylase inhibitory activities

et al. 2023

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Dendrobium nobile is a traditional Chinese medicine and functional food in China, with anti-aging, immunity-enhancing, glucose-lowering and lipid-lowering health functions. In recent years, the research value of D. nobile has attracted the attention of more and more experts and scholars. Today, phytochemical investigation of the stems of Dendrobium nobile Lindl., led to the isolation of five sesquiterpene glycosides, including dendromoniliside D (1), dendronobiloside A (2), dendronobiloside C (3), dendronobiloside D (4), dendroside G (5) and their α-amylase and α-glycosidase inhibitory activities were also investigated. Among them, dendromoniliside D (1), dendroside G (5) were first isolated from D. nobile. And dendronobiloside A (2) and dendronobiloside C (3) exhibited better inhibitory activity against α-glycosidases, respectively. In the case of α-amylase inhibition, dendroside G (5) has a relatively good effect. These results suggest that sesquiterpene glycosides of D. nobile have potential hypoglycemic activity and deserve further research and development.

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“…Modern pharmacology studies have shown that alkaloids can relieve pain, have antipyretic effects, reduce heart rate and blood pressure, slow down respiration, and alleviate barbiturate poisoning [ 8 , 9 ]. Furthermore, alkaloids have numerous therapeutic activities, including hypoglycemic, anti-cataract, anti-tumor, anti-cell withering, and antioxidant activities; they have also been shown to be effective in treatment of Alzheimer’s disease [ 10 , 11 ]. However, D. nobile alkaloids are mainly obtained from three-year-old plants, which are not only expensive because of their long culture duration but also require a lot of space [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Improving large-scale biomass and total alkaloid production of Dendrobium nobile Lindl. using a temporary immersion bioreactor system and MeJA elicitation

et al. 2022

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Background Dendrobium nobile Lindl. is an important pharmacopeial plant with medicinal and ornamental value. This study sought to provide a technical means for the large-scale production of total alkaloid in D. nobile. Seedlings were cultured in vitro using a temporary immersion bioreactor system (TIBS). The four tested immersion frequencies (min/h; 5/2, 5/4, 5/6, and 5/8) influenced the production of biomass and total alkaloid content. In addition, to compare the effects of different concentrations of the phytohormone methyl jasmonate (MeJA) and treatment time on biomass and total alkaloid accumulation, MeJA was added to the TIBS medium after 50 days. Finally, total alkaloid production in semi-solid system (SSS), TIBS, and TIBS combined with the MeJA system (TIBS-MeJA) were compared. Results The best immersion frequency was found to be 5/6 (5 min every 6 h), which ensured appropriate levels of biomass and total alkaloid content in plantlets. The alkaloid content and production level of seedlings were the highest after treatment with 10 μM MeJA separately for 20 and 30 days using TIBS. The maximum content (7.41 mg/g DW) and production level (361.24 mg/L) of total alkaloid on use of TIBS-MeJA were 2.32- and 4.69-fold, respectively, higher in terms of content, and 2.07- and 10.49-fold, respectively, higher in terms of production level than those on using of TIBS (3.20 mg/g DW, 174.34 mg/L) and SSS (1.58 mg/g DW, 34.44 mg/L). Conclusions Our results show TIBS-MeJA is suitable for large-scale production of total alkaloid in in vitro seedlings. Therefore, this study provides a technical means for the large-scale production of total alkaloid in D. nobile.

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Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity

Cited by 32 publications

References 48 publications

RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus

RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus

Identification of sesquiterpene glycosides from Dendrobium nobile and their α-glycosidase and α-amylase inhibitory activities

Improving large-scale biomass and total alkaloid production of Dendrobium nobile Lindl. using a temporary immersion bioreactor system and MeJA elicitation

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