Dendritic spine density and EphrinB2 levels of hippocampal and anterior cingulate cortex neurons increase sequentially during formation of recent and remote fear memory in the mouse

Abate, Georgia; Colazingari, Sandra; Accoto, Alessandra; Conversi, David; Bevilacqua, Arturo

doi:10.1016/j.bbr.2018.02.011

Cited by 31 publications

(30 citation statements)

References 58 publications

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“…What is clear is that passive avoidance training in chickens gives rise to an aversive memory that has measurable neural correlates similar to those observed in mammals. For example, the density of hippocampal synaptic spines is also modified by Pavlovian fear conditioning in mice (Abate et al., 2018).…”

Section: Avian Fearmentioning

confidence: 99%

Avian Emotions: Comparative Perspectives on Fear and Frustration

2019

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Emotions are complex reactions that allow individuals to cope with significant positive and negative events. Research on emotion was pioneered by Darwin’s work on emotional expressions in humans and animals. But Darwin was concerned mainly with facial and bodily expressions of significance for humans, citing mainly examples from mammals (e.g., apes, dogs, and cats). In birds, emotional expressions are less evident for a human observer, so a different approach is needed. Understanding avian emotions will provide key evolutionary information on the evolution of related behaviors and brain circuitry. Birds and mammals are thought to have evolved from different groups of Mesozoic reptiles, theropod dinosaurs and therapsids, respectively, and therefore, their common ancestor is likely to be a basal reptile living about 300 million years ago, during the Carboniferous or Permian period. Yet, birds and mammals exhibit extensive convergence in terms of relative brain size, high levels of activity, sleep/wakefulness cycles, endothermy, and social behavior, among others. This article focuses on two basic emotions with negative valence: fear and frustration. Fear is related to the anticipation of dangerous or threatening stimuli (e.g., predators or aggressive conspecifics). Frustration is related to unexpected reward omissions or devaluations (e.g., loss of food or sexual resources). These results have implications for an understanding of the conditions that promote fear and frustration and for the evolution of supporting brain circuitry.

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Section: Avian Fearmentioning

confidence: 99%

Avian Emotions: Comparative Perspectives on Fear and Frustration

2019

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“…Research in the past 15 years accumulated evidence that the medial prefrontal cortex (mPFC) serves as a critical node in the network of the neocortically based memory traces ( Frankland and Bontempi, 2005 ; Takehara-Nishiuchi, 2020 ; Tonegawa et al, 2018 ; Wiltgen et al, 2004 ). Over weeks of systems consolidation processes, synaptic structures within subregions of the mPFC are gradually modified in a manner dependent on the integrity of the hippocampus ( Abate et al, 2018 ; Kitamura et al., 2017 ; Restivo et al, 2009 ). During the same time window, neurons in the mPFC strengthen their selectivity for memory contents ( Kitamura et al, 2017 ; Morrissey et al, 2017 ; Takehara-Nishiuchi and McNaughton, 2008 ; Weible et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Prefrontal–hippocampal interaction during the encoding of new memories

Takehara‐Nishiuchi

2020

Brain and Neuroscience Advances

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The hippocampus rapidly forms associations among ongoing events as they unfold and later instructs the gradual stabilisation of their memory traces in the neocortex. Although this two-stage model of memory consolidation has gained substantial empirical support, parallel evidence from rodent studies suggests that the neocortex, in particular the medial prefrontal cortex, might work in concert with the hippocampus during the encoding of new experiences. This opinion article first summarises findings from behavioural, electrophysiological, and molecular studies in rodents that uncovered immediate changes in synaptic connectivity and neural selectivity in the medial prefrontal cortex during and shortly after novel experiences. Based on these findings, I then propose a model positing that the medial prefrontal cortex and hippocampus might use different strategies to encode information during novel experiences, leading to the parallel formation of complementary memory traces in the two regions. The hippocampus captures moment-to-moment changes in incoming inputs with accurate spatial and temporal contexts, whereas the medial prefrontal cortex may sort the inputs based on their similarity and integrates them over time. These processes of pattern recognition and integration enable the medial prefrontal cortex to, in real time, capture the central content of novel experience and emit relevancy signal that helps to enhance the contrast between the relevant and incidental features of the experience. This hypothesis serves as a framework for future investigations on the potential top-down modulation that the medial prefrontal cortex may exert over the hippocampus to enable the selective, perhaps more intelligent encoding of new information.

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“…Notably, inactivation of ACA neurons during acquisition of concurrent Meth and sex experience prevented enhancement of drug-seeking during reinstatement, but not during extinction tests, which may instead be driven by other brain areas, such as ventral mPFC (Augur et al, 2016 ). Alternatively, ACA manipulations may have only affected expression of remote memories (Frankland et al, 2004 ; Teixeira et al, 2006 ; Restivo et al, 2009 ; Euston et al, 2012 ; Wartman and Holahan, 2014 ; Jin and Maren, 2015 ; Abate et al, 2018 ; Mashhoori et al, 2018 ) during reinstatement testing which occurred many days after CNO treatments, without affecting recent memory during the first extinction trials, which occurred within hours-to-days after last CNO treatment.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Drug Seeking Following Drug Taking in a Sexual Context Requires Anterior Cingulate Cortex Activity in Male Rats

Kuiper

Lucas

Mai

et al. 2020

Front. Behav. Neurosci.

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Individual variance in vulnerability to develop addictions is influenced by social factors. Specifically, drug-taking in a sexual context appears to enhance further drug-seeking behavior in human users, as these users identify the effects of drugs to enhance sexual pleasure as a primary reason for continued drug use. Methamphetamine (Meth) is commonly used in this context. Similarly, male rats that self-administered Meth immediately followed by sexual behavior display enhanced drug-seeking behavior, including attenuation of extinction and increased reinstatement to seeking of Meth-associated cues. Hence, drug-taking in a sexual context enhances vulnerability for addiction. However, the neural mechanisms by which this occurs are unknown. Here the hypothesis was tested that medial prefrontal cortex is essential for this effect of Meth and sex when experienced concurrently. First it was shown that CaMKII neurons in the anterior cingulate area (ACA) were co-activated by both Meth and sex. Next, chemogenetic inactivation of ACA CaMKII cells using AAV5-CaMKIIa-hM4Di-mCherry was shown not to affect Meth-induced locomotor activity or sexual behavior. Subsequently, chemogenetic inactivation of ACA CaMKII neurons during Meth self-administration followed by sexual behavior was shown to prevent the effects of Meth and sex on enhanced reinstatement of Meth-seeking but did not affect enhanced drug-seeking during extinction tests. These results indicate that ACA CaMKII cell activation during exposure to Meth in a sexual context plays an essential role in the subsequent enhancement of drug-seeking during reinstatement tests.

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Dendritic spine density and EphrinB2 levels of hippocampal and anterior cingulate cortex neurons increase sequentially during formation of recent and remote fear memory in the mouse

Cited by 31 publications

References 58 publications

Avian Emotions: Comparative Perspectives on Fear and Frustration

Avian Emotions: Comparative Perspectives on Fear and Frustration

Prefrontal–hippocampal interaction during the encoding of new memories

Enhancement of Drug Seeking Following Drug Taking in a Sexual Context Requires Anterior Cingulate Cortex Activity in Male Rats

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