Dendritic Potential in Direct Cortical Responses and Seizure Activity

Abstract

SUMMARY For the purpose of studying the electrophysiological activity in the apical dendrites during a seizure, changes of dendritic potentials (DPs) in direct cortical responses were investigated during and after electrically induced seizures. As results, during a seizure, either the DPs were not elicited at all or the DPs depressed in amplitude were elicited. Furthermore, the suppression of the DPs was particulary marked when positive seizure discharges were seen in the cortical surface. In conclusion, from reference to the past studies with intracellular recordings, the suppression of the DPs was considered to indicate that a sustained depolarization took place in the apical dendrites during a seizure and greater depression of the DPs during surface‐positive seizure discharges was seemed to suggest that EPSPs arise in the apical dendrites simultaneously with the surface‐positive seizure discharges.

Visualizing traumatic stress-induced structural plasticity in a medial amygdala pathway using mGRASP

“…Dendritic spines, which are the primary sites for excitatory synaptic input, can be categorized based on their distance from the cell body into proximal and distal spines ( Perez-Rando et al, 2017 ). Their location along the dendrite not only influences their physiological properties but also their stability and turnover rates ( Jibiki et al, 1978 ; Vu and Krasne, 1992 ; Nonaka and Hayashi, 2009 ). Proximal dendritic spines, being closer to the cell body, are generally considered more stable than their distal counterparts.…”