Dendritic Organization of Olfactory Inputs to Medial Amygdala Neurons

Keshavarzi, Sepiedeh; Power, John M.; Albers, Eva H H; Sullivan, Rodney N.; Sah, Pankaj

doi:10.1523/jneurosci.0627-15.2015

Cited by 49 publications

(42 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These neurons may have privileged access to specific decoding circuits in known (and behaviorally-relevant) plCoA targets like the medial amygdala and the olfactory tubercle (although the PCx also innervates both those targets directly) (Agustín-Pavón et al, 2014; Keshavarzi et al, 2015; Li and Liberles, 2015; Novejarque et al, 2011; Ubeda-Bañon et al, 2007). In our recordings, we were unable to identify a statistical excess of such neurons; nevertheless, our experiments cannot definitively rule out the possibility that labeled lines, built from such neurons, exist in plCoA.…”

Section: Discussionmentioning

confidence: 99%

Population Coding in an Innately Relevant Olfactory Area

Iurilli

Datta

2017

Neuron

View full text Add to dashboard Cite

Different olfactory cortical regions are thought to harbor distinct sensory representations, enabling each area to play a unique role in odor perception and behavior. In the piriform cortex (PCx), spatially-dispersed sensory inputs evoke activity in distributed ensembles of neurons that act as substrates for odor learning. In contrast, the posterolateral cortical amygdala (plCoA) receives hardwired inputs that link specific odor cues to innate olfactory behaviors. Here we show that, despite stark differences in the patterning of plCoA and PCx inputs, odor-evoked neural ensembles in both areas are equally capable of discriminating odors, and exhibit similar odor tuning, reliability and correlation structure. These results demonstrate that brain regions mediating odor-driven innate behaviors can, like brain areas involved in odor learning, represent odor objects using distributive population codes; these findings suggest both alternative mechanisms for the generation of innate odor-driven behaviors and additional roles for the plCoA in odor perception.

show abstract

Section: Discussionmentioning

confidence: 99%

Population Coding in an Innately Relevant Olfactory Area

Iurilli

Datta

2017

Neuron

View full text Add to dashboard Cite

show abstract

“…The projections from the ACo back to the vomeronasal amygdala are relatively lighter, with the exception of the projection to the medial nucleus, in agreement with previous results (Petrovich et al, ; Cádiz‐Moretti et al, ). The projection from the ACo to the Me has been proposed to be the substrate allowing the association of olfactory and vomeronasal stimuli (Keshavarzi et al, ; see Guthman and Vera, ).…”

Section: Discussionmentioning

confidence: 99%

Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Cádiz-Moretti

Abellán-Álvaro

Pardo-Bellver

et al. 2017

J of Comparative Neurology

View full text Add to dashboard Cite

The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both the main and accessory olfactory bulbs. The role of this structure is unknown, partially due to a lack of knowledge of its connectivity. In this work, we describe the pattern of afferent and efferent projections of the ACo by using fluorogold and biotinylated dextranamines as retrograde and anterograde tracers, respectively. The results show that the ACo is reciprocally connected with the olfactory system and basal forebrain, as well as with the chemosensory and basomedial amygdala. In addition, it receives dense projections from the midline and posterior intralaminar thalamus, and moderate projections from the posterior bed nucleus of the stria terminalis, mesocortical structures and the hippocampal formation. Remarkably, the ACo projects moderately to the central nuclei of the amygdala and anterior bed nucleus of the stria terminalis, and densely to the lateral hypothalamus. Finally, minor connections are present with some midbrain and brainstem structures. The afferent projections of the ACo indicate that this nucleus might play a role in emotional learning involving chemosensory stimuli, such as olfactory fear conditioning. The efferent projections confirm this view and, given its direct output to the medial part of the central amygdala and the hypothalamic 'aggression area', suggest that the ACo can initiate defensive and aggressive responses elicited by olfactory or, to a lesser extent, vomeronasal stimuli.

show abstract

“…Here we will summarize the roles of other nodes within this extended circuit that project to the VMHvI. (1) The medial amygdala is often referred to as the “olfactory” amygdala due to the massive converging inputs from the accessory and main olfactory systems [24,25]. It projects to the VMHvI both directly and indirectly via the bed nucleus of stria terminalis [26].…”

Section: Hypothalamic Control Of Aggressive Behaviorsmentioning

confidence: 99%

Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression

Yamaguchi

Lin

2018

Current Opinion in Behavioral Sciences

View full text Add to dashboard Cite

Aggression is a crucial survival behavior: it is employed to defend territory, compete for food and mating opportunities, protect kin, and resolve disputes. Although widely differing in its behavioral expression, aggression is observed across many species. The neural substrates of aggression have been investigated for nearly a century and two highly conserved circuitries emerge as critical substrates for generating and modulating aggression. One circuitry centers on the medial hypothalamus. Activity of the medial hypothalamic cells closely correlates with attacks and can bi-directionally modulate aggressive behaviors. The other aggression-related circuit involves the mesolimbic dopamine cells. Dopaminergic antagonists are the most commonly used treatment for suppressing human aggression in psychotic patients. Animal studies support essential roles of dopaminergic signaling in the nucleus accumbens in assessing the reward value of aggression and reinforcing the aggressive behaviors. In this review, we will provide an overview regarding the functions of medial hypothalamus and dopaminergic system in mediating aggressive behaviors and the potential interactions between these two circuitries.

show abstract

Dendritic Organization of Olfactory Inputs to Medial Amygdala Neurons

Cited by 49 publications

References 74 publications

Population Coding in an Innately Relevant Olfactory Area

Population Coding in an Innately Relevant Olfactory Area

Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression

Contact Info

Product

Resources

About