“…The voltage-gated K + channel Kv4.2, responsible for mediating transient A-type currents (I A ), operates within the subthreshold voltage range to perform various physiological functions. These include the regulation of resting membrane potential (RMP) and action potential (AP) repolarization (Kim et al, 2005) as well as the modulation of synaptic response (Hoffman et al, 1997, Migliore et al, 1999, Johnston et al, 2003, Oule et al, 2021). The graded expression of I A in dendrites acts to constrain the integration and propagation of sub- and suprathreshold voltage signals, including dendritic spikes and back-propagating action potential (b-AP) in the hippocampus (Hoffman et al, 1997, Ramakers and Storm 2002, Johnston et al, 2003, Cai et al, 2004, Losonczy et al, 2006).…”