Dendritic glycopolymers based on dendritic polyamine scaffolds: view on their synthetic approaches, characteristics and potential for biomedical applications

Abstract

In this review we highlight the potential for biomedical applications of dendritic glycopolymers based on polyamine scaffolds. The complex interplay of the molecular characteristics of the dendritic architectures and their specific interactions with various (bio)molecules are elucidated with various examples. A special role of the individual sugar units attached to the dendritic scaffolds and their density is identified, which govern ionic and H-bond interactions, and biological targeting, but to a large extent are also responsible for the significantly reduced toxicity of the dendritic glycopolymers compared to their polyamine scaffolds. Thus, the application of dendritic glycopolymers in drug delivery systems for gene transfection but also as therapeutics in neurodegenerative diseases has great promise.

Carboxymethyl chitosan-modified magnetic-cored dendrimer as an amphoteric adsorbent

“…Similar reactions were demonstrated in glycodendrimers that were composed of carbohydrates built around the dendritic backbone [31]. The CCMDs in this study exhibited spherical shapes and mono-sized particles, as seen in the SEM and TEM analyses (Fig.…”

Interaction study between maltose-modified PPI dendrimers and lipidic model membranes

“…The number of surface groups, their charge and the shapes of molecules affect the strength of interaction. Higher generations of dendrimers affect the structure of the lipid bilayer triggered by number of cationic surface groups [27,45,46]. In the present work, we used cationic unmodified PPI dendrimer and cationic open shell PPI glycodendrimer, but also a neutral dense shell glycodendrimer to investigate their interaction with model lipid membranes.…”

“…Thus 4th generation PPI dendrimer is used here in this study. Moreover, all mentioned generations of PPI dendrimers follow the recommending nomenclature of polyamine dendrimers as suggested in a recent review [27]. Maltose-modified 4th-generation PPI dendrimers ( Fig.…”

Pre-Assembly of Near-Infrared Fluorescent Multivalent Molecular Probes for Biological Imaging

“…(1) Covalent synthesis of discrete molecules with dendritic scaffolds that present multiple copies of the targeting ligands. 14,15 This method produces single molecules with precise composition, but the reaction yields are often low at high ligand loading levels and require excess reagents which may make probe purification a wasteful and time consuming process. (2) Statistical attachment of targeting ligands to a polymeric scaffold or nanoparticle surface.…”