Dendritic Chelating Agents. 1. Cu(II) Binding to Ethylene Diamine Core Poly(amidoamine) Dendrimers in Aqueous Solutions

Abstract

Dendrimer SynthesisGeneration 4 EDA core PAMAM dendrimer was purchased from Dendritech (Midland, MI) as methanol solution (26 wt%). Acetic anhydride, pyridine, succinic anhydride, glycidol and all the remaining chemicals/solvents were purchased from Aldrich. Milli-Q deionized water (with resistivity >18 MΩcm) was used in all of the experiments. Regenerated cellulose dialysis membranes were purchased from Fisher Scientific. 4.1 mL of pyridine was added to 11.56 g of a solution of EDA core G4-NH 2 PAMAM dendrimer (3.0056 g) in methanol. The resulting solution was diluted to 40 mL by addition of methanol in a 250-ml round-bottom flask. A solution of 2.6 g acetic anhydride in methanol was then added drop wise to the dendrimer/pyridine mixture under continuous stirring. The resulting solution was equlibrated for 24 hours. The methanol was then removed from the reaction mixture on a rotary evaporator. The oily crude product was diluted and dialyzed with deionized water (6 X 4 liters) for three days to remove the excess reactants and byproducts. The final product was removed from the aqueous retentate, dissolved in deionized water and lyophilized. The yield (3.15g) was estimated at 88.2%. G4 EDA core PAMAM Dendrimer with Acetamide (NHCOCH 3 ) Terminal Groups (G4-Ac)

Multiscale Modeling for Host-Guest Chemistry of Dendrimers in Solution

“…Dendrimers have received increasing attention over the past several decades as attractive candidate materials for a variety of applications such as therapeutic delivery systems [1][2][3][4][5], imaging agents [4,6,7], templates for catalytic metal nanoparticles [8][9][10], and extraction agents for the removal of organic pollutants and toxic metals from water and soil [11][12][13][14]. The breadth across applications is attributed to dendrimers being well-defined, monodisperse nanostructures with tunable critical nanoscale design parameters [15,16], such as size, shape, rigidity, surface functionality, and solvent affinity.…”

The Impact of Seasonal Fluctuations on Rat Liver Mitochondria Response to Tested Compounds— A Comparison between Autumn and Spring. New Insight into Collecting and Interpretation of Experimental Data Originating from Different Seasons

“…Therefore, it was safer to use lower G2.5 concentration when testing its activity. The main assumption of this study was based on the proven chelating properties of half-generations PAMAM dendrimers [3][4][5]. We believed that G2.5 is able to successfully bind excess of Ca 2+ ions and thus limits their input to mitochondria.…”

“…Recently, some papers reported that PAMAM dendrimers were able to bind metal ions [3][4][5]. It was evidenced using different methods that ions can be chelated not only buy dendrimers' terminal groups but also by their internal parts, i.e.…”

“…It was evidenced using different methods that ions can be chelated not only buy dendrimers' terminal groups but also by their internal parts, i.e. by ethylenediamine core [4]. It Scheme 1.…”

Metal ion remediation by polyamidoamine dendrimers: a comparison of metal ion, oxidation state, and titania immobilization

“…The multifunctional nature of dendrimer macromolecules (Astruc et al 2010;Lee et al 2005;Myers et al 2011;Tomalia et al 1990) offers potential advancements for a number of technological applications including drug delivery (Esfand and Tomalia 2001;Kitchens and Ghandehari 2009), nanoparticle synthesis (Bronstein and Shifrina 2011;Kuhn et al 2008;Witham et al 2010;Yamamoto et al 2010;Ye et al 2007), and environmental remediation (Diallo et al 1999(Diallo et al , 2004(Diallo et al , 2005Xu and Zhao 2005). Dendrimers are specifically enticing for environmental purposes because of the high density of internal functional groups and the ability to alter the chemistry of the external functional groups.…”