Dendritic Cells in the Kidney

Nelson, Peter J.

doi:10.1681/asn.2007030273

Cited by 70 publications

(56 citation statements)

References 120 publications

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“…In the normal kidney, rMoPh are responsive to a range of stimuli associated with tissue perturbations such as pathogenassociated molecular patterns, damageassociated molecular patterns (DAMPs), other cell and matrix debris, immunoglobulin, complement components, oxygen tension, adenosine, cytokines, chemokines, and cell-cell contact. [24][25][26][27][28][29] Nonetheless, the specific protective roles of each surveillance mechanism and the possibilities that surveillance mechanisms differ by anatomic location or rMoPh subpopulation have not been extensively investigated to date. Additional studies are needed to increase understanding of how rMoPh respond to cues with varying characteristics and within different renal compartments.…”

Section: Functions Of Rmoph In Surveillance Tolerance and Tissue Cymentioning

confidence: 99%

“…15 This finding supports other reports suggesting migratory and phagocytic properties more typical of DCs. 16,23 However, these early studies could not anticipate the multitude of additional Mø and DC functions now assigned to the renal mononuclear phagocytic system [24][25][26][27][28][29][30] or the fact that functional plasticity-rather than dichotomymight exist depending on cues provided to rMoPh from the environment. 22,29,30 Moreover, the renal mononuclear phagocytic system at steady state changes dramatically during inflammation, in which resident and recruited rMoPh exhibit great heterogeneity and dynamic phenotypes.…”

mentioning

confidence: 99%

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The Renal Mononuclear Phagocytic System

Nelson

Rees

Griffin

et al. 2012

Journal of the American Society of Nephrology

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226

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The renal mononuclear phagocytic system, conventionally composed of macrophages (Mø) and dendritic cells (DCs), plays a central role in health and disease of the kidney. Overlapping definitions of renal DCs and Mø, stemming from historically separate research tracks and the lack of experimental tools to specifically study the roles of these cells in vivo, have generated confusion and controversy, however, regarding their immunologic function in the kidney. This brief review provides an appraisal of the current state of knowledge of the renal mononuclear phagocytic system interpreted from the perspective of immunologic function. Physical characteristics, ontogeny, and known functions of the main subsets of renal mononuclear phagocytes as they relate to homeostasis, surveillance against injury and infection, and immune-mediated inflammatory injury and repair within the kidney are described. Gaps and inconsistencies in current knowledge are used to create a roadmap of key questions to be answered in future research.

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Section: Functions Of Rmoph In Surveillance Tolerance and Tissue Cymentioning

confidence: 99%

mentioning

confidence: 99%

The Renal Mononuclear Phagocytic System

Nelson

Rees

Griffin

et al. 2012

Journal of the American Society of Nephrology

Self Cite

226

230

View full text Add to dashboard Cite

show abstract

“…Innate immunity plays an important role in antigen-independent types of inflammation. DCs affect innate immunity through secretion of various cytokines and chemokines, which act on innate immune cells and renal parenchymal cells [1]. These cytokines and chemokines can be pro-inflammatory or anti-inflammatory and some have a direct pro-fibrotic effect.…”

Section: Cntmentioning

confidence: 99%

The Role of Dendritic Cells in Renal Inflammation

et al. 2014

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Dendritic cells are central orchestrators of the immune response. They communicate with both innate and adaptive immune systems and can aggravate or attenuate renal inflammation depending on the microenvironment and the stage of disease. This review summarizes current knowledge regarding the role of dendritic cells in renal inflammation and highlights the recent advances in understanding their function in the development and resolution of various experimental and human kidney diseases. We anticipate that recent advances in this research area will yield in the near future novel therapeutic strategies targeting DCs to control acute and chronic renal injury.

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“…While subcutaneous transplantation allows extensive exposure of the grafted cells to functional dendritic cells (such as the Langerhans cells that are richly embedded in the skin and are the major antigen presenting cells crucial to present minor antigens of iPSC-derived cells), the dendritic cells in the kidney are of the immature type prone to inducing immune tolerance. 15,16 Therefore, the kidney capsule might not be an appropriate anatomic site in which to study immune responses to minor antigens.…”

Section: The Immunogenicity Of Ipsc-derived Cells In Vitromentioning

confidence: 99%

The immunogenicity of cells derived from induced pluripotent stem cells

2013

Cell Mol Immunol

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With their ability to undergo unlimited self-renewal in culture and to differentiate into all cell types in the body, human embryonic stem cells (hESCs) hold great potential for the treatment of currently incurable diseases. Two hESC-based cell therapies for spinal cord injury and macular degeneration have been advanced into human clinical trials. Despite this rapid progress, one key challenge of hESC-based cell therapy is the allogeneic immune rejection of hESC-derived cells by recipients. This problem could be mitigated by a recent breakthrough in the technology of induced pluripotent stem cells (iPSCs) by nuclear reprogramming of patient-specific somatic cells with defined factors, which could become a renewable source of autologous cells for cell therapy. However, recent studies revealing the abnormal epigenetics, genomic stability and immunogenicity of iPSCs have raised safety concerns over iPSC-based therapy. Recent findings related to the immunogenicity of iPSC derivatives will be summarized in this review.

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Dendritic Cells in the Kidney

Cited by 70 publications

References 120 publications

The Renal Mononuclear Phagocytic System

The Renal Mononuclear Phagocytic System

The Role of Dendritic Cells in Renal Inflammation

The immunogenicity of cells derived from induced pluripotent stem cells

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