Dendritic cells in pregnancy and pregnancy-associated diseases

Wei, Ran; Lai, Nannan; Zhao, Lin; Zhang, Zhen; Zhu, Xiaoxiao; Guo, Qiang; Chu, Chu; Fu, Xiaoxiao; Li, Xia

doi:10.1016/j.biopha.2020.110921

Cited by 29 publications

(24 citation statements)

References 154 publications

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“…DCs interact closely with other immune components and the endocrine system to maintain a pregnancy-friendly environment ( 128 ). As the most effective antigen-presenting cells in the immune system, DCs can regulate the differentiation of T cells ( 129 , 130 ).…”

Section: The Influence Of Other Immune Cells Metabolism Reprogramming On the Establishment Of The Maternal-fetal Interfacementioning

confidence: 99%

Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

Wei

Ding

et al. 2021

Front. Immunol.

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Immunity and metabolism are interdependent and coordinated, which are the core mechanisms for the body to maintain homeostasis. In tumor immunology research, immunometabolism has been a research hotspot and has achieved groundbreaking changes in recent years. However, in the field of maternal-fetal medicine, research on immunometabolism is still lagging. Reports directly investigating the roles of immunometabolism in the endometrial microenvironment and regulation of maternal-fetal immune tolerance are relatively few. This review highlights the leading techniques used to study immunometabolism and their development, the immune cells at the maternal-fetal interface and their metabolic features required for the implementation of their functions, explores the interaction between immunometabolism and pregnancy regulation based on little evidence and clues, and attempts to propose some new research directions and perspectives.

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Section: The Influence Of Other Immune Cells Metabolism Reprogramming On the Establishment Of The Maternal-fetal Interfacementioning

confidence: 99%

Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

Wei

Ding

et al. 2021

Front. Immunol.

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“…Although decidual DCs account for less than 2% of decidual leukocytes, they play a critical role throughout pregnancy by interacting with multiple immune effectors. Because of the common origin, DCs and macrophages share similar phenotypical and functional features ( 10 ). In the first trimester of pregnancy, high expression of IL-1β and TNF-α promotes the recruitment of macrophages which, in turn, trigger the recruitment of DCs into the decidua by releasing macrophage growth factor colony-stimulating factor (M-CSF).…”

Section: Introductionmentioning

confidence: 99%

“…By inducing transforming growth factor β (TGF-β)-mediated proliferation and differentiation of T cells into Treg cells, decidual DCs promote tolerogenic responses, Th2-type cytokines-mediated immunosuppressive functions, and reduce cytotoxic NK cells, thereby favoring trophoblast invasiveness and preventing fetal rejection ( 10 ). In addition, decidual DCs display a close cross-talk with NK cells both directly and indirectly.…”

Section: Introductionmentioning

confidence: 99%

Effects of Vertical Transmission of Respiratory Viruses to the Offspring

et al. 2022

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Overt and subclinical maternal infections in pregnancy can have multiple and significant pathological consequences for the developing fetus, leading to acute perinatal complications and/or chronic disease throughout postnatal life. In this context, the current concept of pregnancy as a state of systemic immunosuppression seems oversimplified and outdated. Undoubtedly, in pregnancy the maternal immune system undergoes complex changes to establish and maintain tolerance to the fetus while still protecting from pathogens. In addition to downregulated maternal immunity, hormonal changes, and mechanical adaptation (e.g., restricted lung expansion) make the pregnant woman more susceptible to respiratory pathogens, such as influenza virus, respiratory syncytial virus (RSV), and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Depending on the infectious agent and timing of the infection during gestation, fetal pathology can range from mild to severe, and even fatal. Influenza is associated with a higher risk of morbidity and mortality in pregnant women than in the general population, and, especially during the third trimester of pregnancy, mothers are at increased risk of hospitalization for acute cardiopulmonary illness, while their babies show higher risk of complications such as prematurity, respiratory and neurological illness, congenital anomalies, and admission to neonatal intensive care. RSV exposure in utero is associated with selective immune deficit, remodeling of cholinergic innervation in the developing respiratory tract, and abnormal airway smooth muscle contractility, which may predispose to postnatal airway inflammation and hyperreactivity, as well as development of chronic airway dysfunction in childhood. Although there is still limited evidence supporting the occurrence of vertical transmission of SARS-CoV-2, the high prevalence of prematurity among pregnant women infected by SARS-CoV-2 suggests this virus may alter immune responses at the maternal-fetal interface, affecting both the mother and her fetus. This review aims at summarizing the current evidence about the short- and long-term consequences of intrauterine exposure to influenza, RSV, and SARS-CoV-2 in terms of neonatal and pediatric outcomes.

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“…Moreover, IL-10-expressing tolerogenic decidual DCs express HLA-G that inhibits lytic dNK cell activity ( 32 , 33 ). Thus, dDCs affect a wide range of biological events during pregnancy and the aberrant differentiation and functions of DCs may interrupt the maternal-fetal tolerance as well as decidualization ( 34 ).…”

Section: Introductionmentioning

confidence: 99%

The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy Loss

et al. 2021

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Recurrent pregnancy loss (RPL) is a common fertility problem that affects 1%-2% of couples all over the world. Despite exciting discoveries regarding the important roles of the decidual natural killer cell (dNK) and regulatory T cell in pregnancy, the immune heterogeneity in patients with unexplained recurrent pregnancy loss (URPL) remains elusive. Here, we profiled the transcriptomes of 13,953 CD45+ cells from three normal and three URPL deciduas. Based on our data, the cellular composition revealed three major populations of immune cells including dNK cell, T cell, and macrophage, and four minor populations including monocytes, dendritic cell (DC), mast cell, and B cell. Especially, we identified a subpopulation of CSF1+ CD59+ KIRs-expressing dNK cells in normal deciduas, while the proportion of this subpopulation was decreased in URPL deciduas. We also identified a small subpopulation of activated dDCs that were accumulated mainly in URPL deciduas. Furthermore, our data revealed that in decidua at early pregnancy, CD8+ T cells exhibited cytotoxic properties. The decidual macrophages expressed high levels of both M1 and M2 feature genes, which made them unique to the conventional M1/M2 classification. Our single-cell data revealed the immune heterogeneity in decidua and the potentially pathogenic immune variations in URPL.

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Dendritic cells in pregnancy and pregnancy-associated diseases

Cited by 29 publications

References 154 publications

Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

Metabolic Reprogramming of Immune Cells at the Maternal-Fetal Interface and the Development of Techniques for Immunometabolism

Effects of Vertical Transmission of Respiratory Viruses to the Offspring

The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy Loss

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