Dendritic cells express CCR7 and migrate in response to CCL19 (MIP-3β) after exposure to Helicobacter pylori

Hansson, Malin; Lundgren, Anna; Elgbratt, Kristina; Quiding‐Järbrink, Marianne; Svennerholm, Ann‐Mari; Johansson, Eva-Liz

doi:10.1016/j.micinf.2005.10.007

Cited by 31 publications

(37 citation statements)

References 37 publications

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“…In H. pylori-associated gastritis, recruitment of T-and B cells, dendritic cells and neutrophil granulocytes is mediated by a variety of chemokines interacting with their cognate receptors such as CCR7, CCR5, CXCR1 and CXCR4 expressed on infiltrating immunological cells. 30,[36][37][38][39][40][41] Consistent with these findings, we also observed upregulated mRNA transcripts of CCR8, CCR9, CXCR3 and CXCR7.…”

Section: Discussionsupporting

confidence: 90%

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

et al. 2013

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Chemokine receptors have a crucial role in the development and progression of lymphoid neoplasms. To determine the chemokine receptor expression profile in gastric mucosa-associated lymphoid tissue (MALT) lymphoma, we performed an expression analysis of 19 chemokine receptors at mRNA levels by using real-time RT-PCR, as well as of five chemokine receptors-CCR8, CCR9, CXCR4, CXCR6 and CXCR7-by immunohistochemistry on human tissue samples of Helicobacter pylori-associated gastritis, gastric MALT lymphoma and gastric extranodal diffuse large B-cell lymphoma originating from MALT lymphoma (transformed MALT lymphoma). Following malignant transformation from H. pylori-associated gastritis to MALT lymphoma, an upregulation of CCR7, CXCR3 and CXCR7, and a loss of CXCR4 were detected. The transformation of gastric MALT lymphomas to gastric extranodal diffuse large B-cell lymphoma was accompanied by upregulation of CCR1, CCR5, CCR7, CCR8, CCR9, CXCR3, CXCR6, CXCR7 and XCR1. Remarkably, CXCR4 expression was exclusively found in nodal marginal B-cell lymphomas and nodal diffuse large B-cell lymphomas but not at extranodal manifestation sites, ie, in gastric MALT lymphomas or gastric extranodal diffuse large B-cell lymphomas. Furthermore, the incidence of bone marrow infiltration (16/51 with bone marrow involvement vs 35/51 with bone marrow involvement; Spearman q ¼ 0467 Po0.001) positively correlated with CXCR4 expression. CXCL12, the ligand of CXCR4 and CXCR7, was expressed by epithelial, endothelial and inflammatory cells, MALT lymphoma cells and was most strongly expressed by extranodal diffuse large B-cell lymphoma cells, suggesting at least in part an autocrine signaling pathway. Our data indicate that CXCR4 expression is associated with nodal manifestation and a more advanced stage of lymphomas and hence, might serve as useful clinical prognostic marker.

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Section: Discussionsupporting

confidence: 90%

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

et al. 2013

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“…2A), which demonstrates their responsiveness to lymphocyte-associated factors. A key role for FRCs is providing survival signals to naive T cells via the expression of IL-7 (11,12) and CCL19 (11); the latter is also important in APC and T-cell migration (11,21,22). All three iFRC lines were positive for expression of il7 and ccl19 mRNA (Fig.…”

Section: Resultsmentioning

confidence: 90%

Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection

Nayak

Schmedt

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Fibroblastic reticular cells (FRCs) are lymphoid stromal cells essential to T-cell migration and survival. Although FRCs are targets of multiple viral infections, little is known about their role during infection due to the cells' scarcity and difficulty in isolating in vivo. To initiate studies of interactions among FRCs, viruses, and immune cells, we isolated and immortalized CD45 − gp38 + CD35 − CD31 − CD44 + VCAM1 + cell lines from C57BL/6 mice designated as immortalized FRC. Using these cloned cell lines, we have established that FRCs express the major histocompatibility complex (MHC) II molecule, a factor necessary for stimulation of CD4 + T cells thought to be expressed primarily by antigen-presenting cells, along with other T-cell stimulatory ligands in an IFN-γ-dependent manner. In this environment, lymphocytic choriomeningitis virus (LCMV)-infected iFRCs activated naive LCMV-specific CD4 + and CD8 + T cells while limiting expansion of effector LCMV-specific T cells. Thus, FRCs effectively presented antigen along with activating signals during viral infection using both MHC I and MHC II molecules, illustrating a previously undescribed interaction with CD4 + T cells and indicating a unique role for FRCs.reticular network | T cell activation | secondary lymphoid stroma

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“…The interaction of DCs with H. pylori gives rise to activation (maturation) of the cells, as shown by enhanced expression of CD80, CD83, CD86, and HLA-DR (47). This is associated with the secretion of IL-6, IL-8, IL-10, and IL-12 (34,36,47,48,58). IL-12 plays a key role in Th1 polarization (78), and DCs stimulated with H. pylori promote Th1 responses in vitro (35).…”

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confidence: 99%

“…IL-12 plays a key role in Th1 polarization (78), and DCs stimulated with H. pylori promote Th1 responses in vitro (35). Following in vitro infection, DCs also express CCR7 and migrate in response to CCL19 (36). Furthermore, DCs may also interact with H. pylori through CD209 (DC-SIGN) that binds H. pylori lipopolysaccharide (LPS) and promotes IL-10 secretion (13).…”

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confidence: 99%

Comparative Analysis of the Interaction of Helicobacter pylori with Human Dendritic Cells, Macrophages, and Monocytes

et al. 2012

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Dendritic cells express CCR7 and migrate in response to CCL19 (MIP-3β) after exposure to Helicobacter pylori

Cited by 31 publications

References 37 publications

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

Chemokine receptors in gastric MALT lymphoma: loss of CXCR4 and upregulation of CXCR7 is associated with progression to diffuse large B-cell lymphoma

Immortalized clones of fibroblastic reticular cells activate virus-specific T cells during virus infection

Comparative Analysis of the Interaction of Helicobacter pylori with Human Dendritic Cells, Macrophages, and Monocytes

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