Dendritic cells directly modulate B cell growth and differentiation

Dubois, Bertrand; Bridon, Jean-Michel; Fayette, Jérôme; Barthélemy, Clarisse; Banchereau, Jacques; Caux, Christophe; Brière, Francine

doi:10.1002/jlb.66.2.224

Cited by 125 publications

(90 citation statements)

References 61 publications

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“…It has been demonstrated that the TGF-β signal activates Smad-independent pathways in cell type dependent, i.e MAPKs such as c-Jun N-terminal kinases (JNK) and extracellular signal-regulated kinases (ERK) (Dubois et al, 1999;Yamaguchi et al, 1995). Further, p38MAPK is a downstream molecule of TGF-β-activated kinase 1 (TAK1) in TGF-β signaling (Hanafusa et al, 1999), and activates CREB in this pathway (Johannessen et al, 2004).…”

Section: Induction Of April Expression By Tgf-β1 Involves the P38mapkmentioning

confidence: 99%

TGF-β1 Stimulates Mouse Macrophages to Express APRIL through Smad and p38MAPK/CREB Pathways

Jang¹,

Kim²,

Seo³

et al. 2011

Molecules and Cells

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Section: Induction Of April Expression By Tgf-β1 Involves the P38mapkmentioning

confidence: 99%

TGF-β1 Stimulates Mouse Macrophages to Express APRIL through Smad and p38MAPK/CREB Pathways

Jang¹,

Kim²,

Seo³

et al. 2011

Molecules and Cells

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“…In addition, DCs can interact with B cells (18) and NK cells (19). In vitro, human DCs can be grown from monocytes in the presence of GM-CSF and IL-4 (20), and from CD34 ϩ bone marrow stem cells in medium supplemented with GM-CSF and TNF-␣ (21).…”

mentioning

confidence: 99%

Mesenchymal Stem Cells Inhibit Generation and Function of Both CD34+-Derived and Monocyte-Derived Dendritic Cells

Nauta

Kruisselbrink²,

Lurvink³

et al. 2006

The Journal of Immunology

642

384

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Mesenchymal stem cells (MSCs) are not only able to evade the immune system, but they have also been demonstrated to exert profound immunosuppressive properties on T cell proliferation. However, their effect on the initiators of the immune response, the dendritic cells (DCs), are relatively unknown. In the present study, the effects of human MSCs on the differentiation and function of both CD34+-derived DCs and monocyte-derived DCs were investigated. The presence of MSCs during differentiation blocked the differentiation of CD14+CD1a− precursors into dermal/interstitial DCs, without affecting the generation of CD1a+ Langerhans cells. In line with these observations, MSCs also completely prevented the generation of immature DCs from monocytes. The inhibitory effect of MSCs on DC differentiation was dose dependent and resulted in both phenotypical and functional modifications, as demonstrated by a reduced expression of costimulatory molecules and hampered capacity to stimulate naive T cell proliferation. The inhibitory effect of MSCs was mediated via soluble factors. Taken together, these data demonstrate that MSCs, next to the antiproliferative effect on T cells, have a profound inhibitory effect on the generation and function of both CD34+-derived and monocyte-derived DCs, indicating that MSCs are able to modulate immune responses at multiple levels.

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“…In addition to the role of PDCs for supporting B cell activation, MDCs have been shown to produce factors that promote B cell differentiation (37,38). These may act together with one or several TNF-related soluble or transmembrane-bound molecules, such as a proliferation-inducing ligand and B cell-activating factor (BAFF), produced by MDCs or other DC subsets (39,40).…”

mentioning

confidence: 99%

Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

Douagi

Gujer

Sundling

et al. 2009

The Journal of Immunology

103

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Dendritic cells directly modulate B cell growth and differentiation

Cited by 125 publications

References 61 publications

TGF-β1 Stimulates Mouse Macrophages to Express APRIL through Smad and p38MAPK/CREB Pathways

TGF-β1 Stimulates Mouse Macrophages to Express APRIL through Smad and p38MAPK/CREB Pathways

Mesenchymal Stem Cells Inhibit Generation and Function of Both CD34+-Derived and Monocyte-Derived Dendritic Cells

Human B Cell Responses to TLR Ligands Are Differentially Modulated by Myeloid and Plasmacytoid Dendritic Cells

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