Dendritic Cells Conditionally Transformed by v-relER Oncogene Express Lymphoid Marker Genes

Madruga, Jaime; Briegel, Karoline J.; Diebold, Sandra S.; Boehmelt, Guido; Vogel, Frank; Zenke, Martin

doi:10.1016/s0171-2985(00)80042-x

Cited by 3 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, dendritic cells, T and B cells, and natural killer cells could be differentiated from fetal marrow CD34+CD10+CD45RA+ common hematopoietic precursor cells (23). Moreover, conditional transformation of chicken bone marrow progenitors with v-rel estrogen receptor fusion gene induces dendritic cells expressing cCD3 and lymphoid transcription factor GATA-3 (24). Therefore, the expression of cCD3 in the plasmacytoid monocyte tumor appears to reflect ontogenic relation between T cells and plasmacytoid monocytes or "dedifferentiation" of neoplastic plasmacytoid monocyte toward common T and dendritic cell progenitor.…”

Section: Discussionmentioning

confidence: 99%

CD4+CD56+CD68+Hematopoietic Tumor of Probable Plasmacytoid Monocyte Derivation with Weak Expression of Cytoplasmic CD3

Kim

Park

et al. 2002

J Korean Med Sci

View full text Add to dashboard Cite

Hematopoietic neoplasm coexpressing CD4 and CD56 includes a subset of acute myeloid leukemia with myelomonocytic differentiation, plasmacytoid monocyte tumor, and other immature hematopoietic neoplasms of undefined origin. Herein, we report a CD4+CD56+CD68+ hematopoietic tumor that was thought to be a tumor of plasmacytoid monocytes. This case is unique in the absence of accompanying myelomonocytic leukemia and the faint expression of cCD3 on the tumor cells. The patient was a 22-yr old man presented with multiple lymphadenopathy and an involvement of the bone marrow. Tumor cells were large and monomorphic with an angulated eosinophilic cytoplasm of moderate amount. Nuclei of most tumor cells were eccentric and round with one or two prominent nucleoli. Rough endoplasmic reticulum was prominent in electron microscopic examination. Tumor cells expressed CD4, CD7, CD10, CD45RB, CD56, CD68, and HLA-DR and were negative for CD1a, CD2, sCD3, CD5, CD13, CD14, CD20, CD33, CD34, CD43, CD45RA, TIA-1, S-100, and TdT. cCD3 was not detected in the immunostaining using paraffin tissue, but was faintly expressed in flow cytometry and immunostaining using a touch imprint slide. T-cell receptor gene rearrangement analysis and EBV in situ hybridization showed negative results. Cytochemically, myeloperoxidase, Sudan black B, and alpha naphthyl butyrate esterase were all negative.

show abstract

Section: Discussionmentioning

confidence: 99%

CD4+CD56+CD68+Hematopoietic Tumor of Probable Plasmacytoid Monocyte Derivation with Weak Expression of Cytoplasmic CD3

Kim

Park

et al. 2002

J Korean Med Sci

View full text Add to dashboard Cite

show abstract

Methods for Assessing the In Vitro Transforming Activity of NF-κB Transcription Factor c-Rel and Related Proteins

Gilmore

Gélinas

2015

Methods in Molecular Biology

View full text Add to dashboard Cite

Among NF-κB transcription factors, c-Rel and c-Rel-derived proteins, including v-Rel, are the only ones that have shown consistent and frank transforming activity in cell culture. In particular, viral, chicken, mouse, and human Rel proteins can rapidly transform primary chicken spleen and bone marrow cells. Overexpression of a human Rel protein missing a C-terminal transactivation domain can also enhance the transformed state of the human B-lymphoma cell line BJAB. As described in this chapter, these in vitro assays can be used to quantitatively assess the transforming activity of Rel proteins.

show abstract

Avian dendritic cells: Phenotype and ontogeny in lymphoid organs

Nagy

Bódi

Oláh

2016

Developmental & Comparative Immunology

View full text Add to dashboard Cite

Dendritic Cells Conditionally Transformed by v-relER Oncogene Express Lymphoid Marker Genes

Cited by 3 publications

References 38 publications

CD4+CD56+CD68+Hematopoietic Tumor of Probable Plasmacytoid Monocyte Derivation with Weak Expression of Cytoplasmic CD3

CD4+CD56+CD68+Hematopoietic Tumor of Probable Plasmacytoid Monocyte Derivation with Weak Expression of Cytoplasmic CD3

Methods for Assessing the In Vitro Transforming Activity of NF-κB Transcription Factor c-Rel and Related Proteins

Avian dendritic cells: Phenotype and ontogeny in lymphoid organs

Contact Info

Product

Resources

About