2006
DOI: 10.1080/10428190500360971
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Dendritic cells are significantly reduced in non-Hodgkin's lymphoma and express less CCR7 and CD62L

Abstract: Despite the lack of tumor control, infiltration of immune cells has been demonstrated for several malignancies including non-Hodgkin's lymphoma. Since dendritic cells play a pivotal role in the initiation and control of the immune response, the frequency and phenotype of recently described sub-types of dendritic cells in non-Hodgkin's lymphoma were characterized. Myeloid and plasmacytoid dendritic cells were analysed in 55 non-Hodgkin's lymphoma and 33 reactive lymph nodes by flow cytometry and immunohistochem… Show more

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Cited by 30 publications
(21 citation statements)
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References 42 publications
(40 reference statements)
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“…There are several studies drawing the issue about dendritic cells and T cells in B-cell lymphomas (22,33,34). However, we found for the first time that the peritumoral distribution of S100 + cells and CD45RO + T cells was correlated with a favorable prognosis in DLBCL.…”
Section: Discussionmentioning
confidence: 52%
“…There are several studies drawing the issue about dendritic cells and T cells in B-cell lymphomas (22,33,34). However, we found for the first time that the peritumoral distribution of S100 + cells and CD45RO + T cells was correlated with a favorable prognosis in DLBCL.…”
Section: Discussionmentioning
confidence: 52%
“…The characterization of dendritic cells in NHL and the expression of adhesion molecules, costimulatory molecules, chemokine receptors and activation markers have been analysed in a few studies. Significantly decreased expression of CD62L and CCR7, receptors necessary for lymph node homing, was identified in dendritic cells in NHL 86 . Dendritic cells are also phenotypically altered and reduced in number in NHL, potentially contributing to the loss of tumour control in these patients.…”
Section: The Role Of Chemokines and Their Receptors In The Migrationmentioning
confidence: 99%
“…12 DCs are not only reduced in numbers especially in proximity of the cancer, [13][14][15] but are also characterized by an altered maturation phenotype, 1,16 which-at least in part-can be induced by factors such as IL10 or VEGF in maturing DCs in vitro. 1,13,17 Some early indications of the molecular mechanisms by which these factors might lead to the generation of tolerogenic DCs have recently been reported.…”
Section: Introductionmentioning
confidence: 99%