Dendritic cells and cytokines in human inflammatory and autoimmune diseases

Blanco, Patrick; Palucka, A. Karolina; Pascual, Virginia; Banchereau, Jacques

doi:10.1016/j.cytogfr.2007.10.004

Cited by 457 publications

(398 citation statements)

References 160 publications

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“…9, No. 3; induce their effects on the immune system by direct cell-cell contact or by secretion of multiple cytokines including IL-1, IL-6, IL-12 (to which IL-23 belongs), tumor necrosis factor-ɑ and interfron-ɑ/β (Blanco et al, 2008). High serum and cervical levels have been observed for some of the cytokines (such as IL-6 and IL-23) in women with URSA (Galazios et al, 2011;Hattori et al, 2007).…”

Section: Discussionmentioning

confidence: 94%

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Samimi¹,

Foroozanfard²,

Amini³

et al. 2016

GJHS

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Background: Recurrent spontaneous abortion is a serious problem in pregnancy, which affects between 2 and 5% of women of reproductive age. This study was designed to examine the effect of vitamin D supplementation on the occurrence of unexplained recurrent spontaneous abortion (URSA). Methods:A double-blind randomized and controlled clinical trial was performed on 80 patients with URSA. They were treated with vaginal progesterone (400 IU/day) after confirmation of pregnancy and received vitamin D and placebo in two intervention (n=40) and control groups (n=40), respectively. The incidence of abortion and the serum levels of IL-23 were examined within 20 weeks of gestation. Results:The levels of vitamin D3 prior to the start of the study were equal to 11.65±3.76 ng/ml and 11.53±2.39 ng/ml (p=0.86) in the intervention and control groups, respectively, which were decreased to 13.21±3.47 ng/ml and 11.08±2.76 ng/ml (p=0.004) at the end of the study, when the mean serum levels of IL-23 were equal to 18.4±3.78 pg/ml and 23.16±4.74 pg/ml in the two groups (p <0.004). The frequency of abortion in the control and intervention groups was equal to 5 (12.8%) and 13 (34.2%), respectively (p=0.03, OR=3.53, 95% CI= 1.12-11.2). Conclusions:Vitamin D3 leads to decreased serum levels of IL-23 and incidence of abortion among women with URSA.

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Section: Discussionmentioning

confidence: 94%

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Samimi¹,

Foroozanfard²,

Amini³

et al. 2016

GJHS

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“…To identify this specific role of W-PG we assayed multiple cytokines and chemokines since the cytokines released from DCs are known to enable not only paracrine activations to lymphocytes but also autocrine activations to themselves. 31,32) A significant difference was observed in the secretion of certain cytokines between the stimulation with MIX and MIXϩW-PG (Table 1). iDCs express a unique repertoire of inflammatory chemokine receptors such as CCR2, CCR3, and CCR5.…”

Section: Discussionmentioning

confidence: 99%

Proteoglycans Regulate the Chemotaxis of Dendritic Cells Derived from Human Peripheral Blood Monocytes

Yoshino

Takahashi

Monzen

et al. 2010

Biological & Pharmaceutical Bulletin

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Dendritic cells (DCs) are a type of antigen-presenting cell which play an essential role in the immune system. The transition from immature DC (iDCs) to mature DCs (mDCs) requires appropriate maturation stimuli, such as pro-inflammatory cytokines or pathogen-derived components. Proteoglycans (PGs), which are composed of core proteins and the glycosaminoglycans that bind to them, are one of the main components of the extracellular matrix around pathogens such as bacteria. This study investigated the effects of PG extracted from the nasal septum cartilage of whale (W-PG) on the maturation of DCs derived from human peripheral blood monocytes. iDCs were prepared from human monocytes using granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4). The iDCs were stimulated by W-PG alone. In another type of experiment, the iDCs were stimulated by MIX (tumor necrosis factor-a a (TNF-a a), IL-1b b, IL-6 and prostaglandin E 2 (PGE 2 )) or a combination of MIX plus W-PG. The stimulation of W-PG alone did not induce the phenotypic maturation from iDCs. However, W-PG promoted the up-regulation of chemokine receptor CCR7-surface expression and the chemotactic responsiveness to CCR7 ligand macrophage inflammatory protein-3b b on MIX-stimulated mDCs although W-PG did not influence matrix metalloproteinase-9 activity which is an important factor in DC migration through the extracellular matrix. The findings that W-PG can selectively regulate the chemotactic activity of DCs in vitro under inflammatory conditions therefore indicate that the interaction of PGs with immune cells including DCs plays an important role in the immune response under the milieu of innate immunity.

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“…Langerhans cells were characterised as permissive cells for DENV in vivo replication (Wu et al 2000). Indeed, DCs have a crucial role in initiating host defence mechanisms; through antigen presentation and cytokine production, they can define the fate of the immunological response (Blanco et al 2008). Both DENV and YF vaccine viruses are known to infect DCs and monocytes in vitro (Wu et al 2000, Barba-Spaeth et al 2005, Reis et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles

Gandini

Reis

Torrentes-Carvalho

et al. 2011

Mem. Inst. Oswaldo Cruz

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Flaviviruses cause severe acute febrile and haemorrhagic infections, including dengue and yellow fever and the pathogenesis of these infections is caused by an exacerbated immune response. Dendritic cells (DCs) are targets for dengue virus (DENV) and yellow fever virus (YF) replication and are the first cell population to interact with these viruses during a natural infection, which leads to an induction of protective immunity in humans. We studied the infectivity of DENV2 (strain 16681), a YF vaccine (YF17DD) and a chimeric YF17D/DENV2 vaccine in monocytederived DCs in vitro with regard to cell maturation, activation and cytokine production. Higher viral antigen positive cell frequencies were observed for DENV2 when compared with both vaccine viruses. Flavivirus-infected cultures exhibited dendritic cell activation and maturation molecules. CD38 expression on DCs was enhanced for both DENV2 and YF17DD, whereas OX40L expression was decreased as compared to mock-stimulated cells, suggesting that a T helper 1 profile is favoured. Tumor necrosis factor (TNF)-α production in cell cultures was significantly higher in DENV2-infected cultures than in cultures infected with YF17DD or YF17D/DENV. In contrast, the vaccines induced higher IFN-α levels than DENV2. The differential cytokine production indicates that DENV2 results in TNF induction, which discriminates it from vaccine viruses that preferentially stimulate interferon expression. These differential response profiles may influence the pathogenic infection outcome.Key words: cytokines -dendritic cells -dengue virus -yellow fever vaccine -flavivirus dendritic cell activation by flavivirus • Mariana Gandini et al.

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Dendritic cells and cytokines in human inflammatory and autoimmune diseases

Cited by 457 publications

References 160 publications

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Effect of Vitamin D Supplementation on Unexplained Recurrent Spontaneous Abortion: A Double-Blind Randomized Controlled Trial

Proteoglycans Regulate the Chemotaxis of Dendritic Cells Derived from Human Peripheral Blood Monocytes

Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-α and IFN-α profiles

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