Dendritic Cell–Targeted Therapies to Treat Neurological Disorders

Hussain, Altaf; Rafeeq, Hamza; Munir, Nimra; Jabeen, Zara; Afsheen, Nadia; Rehman, Khalil Ur; Bilal, Muhammad; Iqbal, Hafiz M.N.

doi:10.1007/s12035-021-02622-4

Cited by 3 publications

(1 citation statement)

References 151 publications

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“…These are selectins and CAMs, known to attract leukocytes as DCs. In this context, it appears that DCs could be an interesting target for therapy (167).…”

Section: Dendritic Cells and Brain Antiviral Responsementioning

confidence: 99%

Role of Dendritic Cells in Viral Brain Infections

et al. 2022

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To gain access to the brain, a so-called immune-privileged organ due to its physical separation from the blood stream, pathogens and particularly viruses have been selected throughout evolution for their use of specific mechanisms. They can enter the central nervous system through direct infection of nerves or cerebral barriers or through cell-mediated transport. Indeed, peripheral lymphoid and myeloid immune cells can interact with the blood–brain and the blood–cerebrospinal fluid barriers and allow viral brain access using the “Trojan horse” mechanism. Among immune cells, at the frontier between innate and adaptive immune responses, dendritic cells (DCs) can be pathogen carriers, regulate or exacerbate antiviral responses and neuroinflammation, and therefore be involved in viral transmission and spread. In this review, we highlight an important contribution of DCs in the development and the consequences of viral brain infections.

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“…These are selectins and CAMs, known to attract leukocytes as DCs. In this context, it appears that DCs could be an interesting target for therapy (167).…”

Section: Dendritic Cells and Brain Antiviral Responsementioning

confidence: 99%

Role of Dendritic Cells in Viral Brain Infections

et al. 2022

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Targeting immunometabolism against acute lung injury

Shishi

Wang

et al. 2023

Clinical Immunology

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CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation

Zhuang,

Zhou,

Zhong

et al. 2023

Cell Death Dis

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Chemokines secreted by dendritic cells (DCs) play a key role in the regulation of inflammation and autoimmunity through chemokine receptors. However, the role of chemokine receptor CXCR1 in inflammation-inducing experimental autoimmune encephalomyelitis (EAE) and acute respiratory distress syndrome (ARDS) remains largely enigmatic. Here we reported that compared with healthy controls, the level of CXCR1 was aberrantly increased in multiple sclerosis (MS) patients. Knockout of CXCR1 not only ameliorated disease severity in EAE mice but also suppressed the secretion of inflammatory factors (IL-6/IL-12p70) production. We observed the same results in EAE mice with DCs-specific deletion of CXCR1 and antibody neutralization of the ligand CXCL5. Mechanically, we demonstrated a positive feedback loop composed of CXCL5/CXCR1/HIF-1α direct regulating of IL-6/IL-12p70 production in DCs. Meanwhile, we found CXCR1 deficiency in DCs limited IL-6/IL-12p70 production and lung injury in LPS-induced ARDS, a disease model caused by inflammation. Overall, our study reveals CXCR1 governs DCs-mediated inflammation and autoimmune disorders and its potential as a therapeutic target for related diseases.

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Dendritic Cell–Targeted Therapies to Treat Neurological Disorders

Cited by 3 publications

References 151 publications

Role of Dendritic Cells in Viral Brain Infections

Role of Dendritic Cells in Viral Brain Infections

Targeting immunometabolism against acute lung injury

CXCR1 drives the pathogenesis of EAE and ARDS via boosting dendritic cells-dependent inflammation

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