Dendritic cell subsets

Macri, Christophe; Pang, Ee Shan; Patton, Timothy; O’Keeffe, Meredith

doi:10.1016/j.semcdb.2017.12.009

Cited by 199 publications

(200 citation statements)

References 141 publications

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“…DCs present antigens to activate antitumor T cells. Mature DCs in lung cancer express high levels of cytokines and costimulatory molecules (CD40/80/86) to activate T cells (Macri et al, 2018). MHC type II molecules on DCs promote the activation of CD4 + T cells.…”

Section: Discussionmentioning

confidence: 99%

FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma

Yuan

Feng

Wang

et al. 2020

PeerJ

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Lung cancer is the most common malignant tumor, accounting for 25% of cancerrelated deaths and 14% of new cancers worldwide. Lung adenocarcinoma is the most common type of pulmonary cancer. Although there have been some improvements in the traditional therapy of lung cancer, the outcome and prognosis of patients remain poor. Lung cancer is the leading cause of cancer-related deaths worldwide, with 1.8 million new cases being diagnosed each year. Precision medicine based on genetic alterations is considered a new strategy of lung cancer treatment that requires highly specific biomarkers for precision diagnosis and treatment. Fibrinogen-like protein 2 (FGL2) plays important roles in both innate and adaptive immunity. However, the diagnostic value of FGL2 in lung cancer is largely unknown. In this study, we systematically investigated the expression profile and potential functions of FGL2 in lung adenocarcinoma. We used the TCGA and Oncomine datasets to compare the FGL2 expression levels between lung adenocarcinoma and adjacent normal tissues. We utilized the GEPIA, PrognoScan and Kaplan-Meier plotter databases to analyze the relationship between FGL2 expression and the survival of lung adenocarcinoma patients. Then, we investigated the potential roles of FGL2 in lung adenocarcinoma with the TIMER database and functional enrichment analyses. We found that FGL2 expression was significantly lower in lung adenocarcinoma tissue compared with adjacent normal tissue. A high expression level of FGL2 was correlated with better prognostic outcomes of lung adenocarcinoma patients, including overall survival and progression-free survival. FGL2 was positively correlated with the infiltration of immune cells, including dendritic cells, CD8 + T cells, macrophages, B cells, and CD4 + T cells, in lung adenocarcinoma. Functional enrichment analyses also showed that a high expression level of FGL2 was positively correlated with enhanced T cell activities, especially CD8 + T cell activation. Thus, we propose that high FGL2 expression, which is positively associated with enhanced antitumor activities mediated by T cells, is a beneficial marker for lung adenocarcinoma treatment outcomes. . 2020. FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma. PeerJ 8:e8654 http://doi.BE, Golub TR, Sugarbaker DJ, Meyerson M. 2001. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Said JW, McBride WH, Kabbinavar FF, Ribas A, Pantuck AJ, Belldegrun AS, Riss J. 2013. Dendritic cell-based immunotherapy in prevention and treatment of renal cell carcinoma: efficacy, safety, and activity of Ad-GM·CAIX in immunocompetent mouse models. Journal T. 2013. Soluble FGL2 induced by tumor necrosis factor-α and interferon-γ in CD4+ T cells through MAPK pathway in human renal allograft acute rejection.

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Section: Discussionmentioning

confidence: 99%

FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma

Yuan

Feng

Wang

et al. 2020

PeerJ

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“…DCs comprise two major distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs), which are also called conventional or classical DCs (cDCs) [16]. The cDCs are professional antigen presenting cells characterized by an incredible ability to capture antigens and the expression of high levels of major histocompatibility (MHC) class II and co-stimulatory molecules which enables them to stimulate T cells [9].…”

Section: Alterations In the Composition Of The DC Subgroups During Sementioning

confidence: 99%

Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis

Wang

Zhang

et al. 2020

Genes

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Dendritic cells (DCs) play a critical role in the immune system which sense pathogens and present their antigens to prime the adaptive immune responses. As the progression of sepsis occurs, DCs are capable of orchestrating the aberrant innate immune response by sustaining the Th1/Th2 responses that are essential for host survival. Hence, an in-depth understanding of the characteristics of DCs would have a beneficial effect in overcoming the obstacle occurring in sepsis. This paper focuses on the role of DCs in the progression of sepsis and we also discuss the reverse sepsis-induced immunosuppression through manipulating the DC function. In addition, we highlight some potent immunotherapies that could be used as a novel strategy in the early treatment of sepsis.

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“…Depending on whether the antigen came from an extracellular pathogen like a bacterium or an intracellular pathogen—such as a virus, APCs display antigen in either MHCI or MHCII to stimulate the type of adaptive immune response that is most effective for clearing that class of pathogen . Extracellular pathogens such as bacteria are internalized by APCs and enzymatically degraded in endosomes; the resulting protein fragments (antigens) are then loaded into MHCII molecules to activate helper T cells that support the production of antibodies . Antibodies are proteins that can bind, inactivate, or tag extracellular pathogens for destruction.…”

Section: Immune Responses Rely On Coordinated Cell and Tissue Interacmentioning

confidence: 99%

“…Lastly, the third type of signals involved in T and B cell activation are the soluble signals secreted by APCs known as cytokines. These proteins promote—and later regulate, immune cell proliferation and differentiation . Specific cytokines or combinations of cytokines expressed by APCs can influence T or B cells toward the development of specific phenotypes and functions.…”

Section: Immune Responses Rely On Coordinated Cell and Tissue Interacmentioning

confidence: 99%

“…[31] Extracellular pathogens such as bacteria are internalized by APCs and enzymatically degraded in endosomes; the resulting protein fragments (antigens) are then loaded into MHCII molecules to activate helper T cells that support the production of antibodies. [42] Antibodies are proteins that can bind, inactivate, or tag extracellular pathogens for destruction. In contrast, virally infected cells already have antigen (i.e., the virus) in the infected cell's cytoplasm, which ultimately results in loading of the antigen into MHCI molecules.…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

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Biomaterials as Tools to Decode Immunity

Eppler¹,

Jewell

2019

Advanced Materials

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The immune system has remarkable capabilities to combat disease with exquisite selectivity. This feature has enabled vaccines that provide protection for decades and, more recently, advances in immunotherapies that can cure some cancers. Greater control over how immune signals are presented, delivered, and processed will help drive even more powerful options that are also safe. Such advances will be underpinned by new tools that probe how immune signals are integrated by immune cells and tissues. Biomaterials are valuable resources to support this goal, offering robust, tunable properties. The growing role of biomaterials as tools to dissect immune function in fundamental and translational contexts is highlighted. These technologies can serve as tools to understand the immune system across molecular, cellular, and tissue length scales. A common theme is exploiting biomaterial features to rationally direct how specific immune cells or organs encounter a signal. This precision strategy, enabled by distinct material properties, allows isolation of immunological parameters or processes in a way that is challenging with conventional approaches. The utility of these capabilities is demonstrated through examples in vaccines for infectious disease and cancer immunotherapy, as well as settings of immune regulation that include autoimmunity and transplantation.

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Dendritic cell subsets

Cited by 199 publications

References 141 publications

FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma

FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma

Crosstalk between Dendritic Cells and Immune Modulatory Agents against Sepsis

Biomaterials as Tools to Decode Immunity

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