Dendritic cell neurofibroma with pseudorosettes: One case report and literature review

Huang, Hsin-Yin; Wu, Yu‐Hung; Hsieh, Yu‐Ting

doi:10.1016/j.dsi.2012.01.001

Cited by 3 publications

(9 citation statements)

References 6 publications

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“…The exact etiology of the disease is unknown. It typically presents as a sporadic, solitary skin‐colored papule or nodule (mean size: 8 mm) and can arise on different parts of the body, most often the trunk 4‐12 . A skin biopsy is necessary to make a diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Both types I and II cells stain positively for S100 and CD57, suggesting neural differentiation with a dermal interstitial dendritic cell lineage. CD34 has also been established as a useful marker in identifying fibroblasts in the stroma 8 . EMA IHC can identify focal perineurium around the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…DCNP has a benign clinical course and is usually managed by excision for cosmetic reasons or if the lesion is bothersome. There have not been any reports of malignancy or reoccurrence 4‐12 …”

Section: Discussionmentioning

confidence: 99%

“…In 2002, Woodruff et al debated this finding and instead suggested it may be an atypical type of melanocytic nevus with neural differentiation due to the lesion having S100 protein reactivity and multifocal tumor growth 13 . However, subsequent cases refuted this theory and have supported DCNP to be a true PNST after additional immunohistochemical staining with CD57 showed neural differentiation 8 . In April 2020, Saggini et al had conflicting opinions about its classification as a neurofibroma.…”

Section: Discussionmentioning

confidence: 99%

“…It typically presents as a sporadic, solitary skincolored papule or nodule (mean size: 8 mm) and can arise on different parts of the body, most often the trunk. [4][5][6][7][8][9][10][11][12] A skin biopsy is necessary type II cells to form the distinctive pseudorosette. 4 It is beneficial to use immunohistochemical (IHC) staining to differentiate it from other forms of neurofibromas accurately.…”

Section: Discussionmentioning

confidence: 99%

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Dendritic cell neurofibroma with pseudorosettes

Ramos

Roberts

2021

J Cutan Pathol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Dendritic cell neurofibroma with pseudorosettes

Ramos

Roberts

2021

J Cutan Pathol

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Histopathological Variants of Cutaneous Neurofibroma: A Compendious Review

Nagrani

Bhawan

2022

Dermatopathology

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The first description of histopathological variants of neurofibroma dates back to 1994. Over the years, many individual case reports elucidating unusual histologic features in neurofibroma have been added to the literature, some of which have defined criteria, with the others falling under the roof of benign neural neoplasms. These unusual features, which sometimes may lead to pauses in identifying a common benign tumor such as neurofibroma. Awareness of these variants may help dermatopathologists avoid misinterpretation. Thus, this review aims to summarize all novel and unusual histopathological variants of cutaneous neurofibroma reported to date, in addition to any unusual variants that we encountered in our practice.

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Dendritic Cell Neurofibroma with Pseudorosette: An Uncharted Entity at Unusual Sites: Two Case Reports with Literature Review

Mohanty,

Kar

2024

Journal of Dermatology and Dermatologic Surgery

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Dendritic cell neurofibroma with pseudorosette (DCNP) is a novel entity of neurofibroma with sparse literature. Neurofibroma is a benign peripheral nerve sheath tumor having many known histological variants including localized, diffuse, plexiform, solitary, cellular, and atypical forms, all of which lead an indolent course. Like other forms of neurofibroma, DCNP usually is located in the dermis or deeper soft tissue or within the nerve trunk. It reveals a characteristic histomorphology of distinct multiple nodules comprising two types of cells: the outer lymphocyte like dark Type I cells (Schwann cell-like) forming pseudorosettes surrounding the inner scattered lighter and larger Type II cells (ganglion/dendritic cell-like). Although histogenesis of these two type of cells is debatable, immunopositivity for S100 suggests the neuronal origin and the fibrous pseudocapsule covering tumor nodules being immunopositive to epithelial membrane antigen (EMA) suggests perineurium. Here, we report two such cases of DCNP at two different yet unusual sites of cervical and perianal regions. Neither patient nor their family members had any features of neurofibromatosis(NF 1). Both the cases were adults, presented with firm nontender subcutaneous nodules of long duration causing pressure symptoms. Those were resected and evaluated for microscopy. Histomorphology aided by immunohistochemistry positivity for S100 and EMA confirmed DCNP. Follow up study after half an year of surgery was uneventful and Patients were found to be relieved of all symptoms. We present this unusual new variant that poses challenge for it’s close histological mimickers like cellular/epithelioid schwannoma and plexiform neuroma and yet want to emphasize the innocuous behavior of tumor that can be cured by surgical resection.

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Dendritic cell neurofibroma with pseudorosettes: One case report and literature review

Cited by 3 publications

References 6 publications

Dendritic cell neurofibroma with pseudorosettes

Dendritic cell neurofibroma with pseudorosettes

Histopathological Variants of Cutaneous Neurofibroma: A Compendious Review

Dendritic Cell Neurofibroma with Pseudorosette: An Uncharted Entity at Unusual Sites: Two Case Reports with Literature Review

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