Dendritic cell metabolism

Pearce, Edward J.; Everts, Bart

doi:10.1038/nri3771

Cited by 420 publications

(458 citation statements)

References 122 publications

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“…After activation these cells undergo considerable morphological changes and are characterized as mature classic DCs. Just as in macrophages, the activation of DCs is accompanied by a shift in cellular metabolism favouring glycolysis over oxidative phosphorylation (Pearce & Everts 2015). Mature DCs are capable of migrating to lymph nodes and subsequent antigen presentation to T cells, initiating and shaping the adaptive immune response.…”

Section: Dendritic Cellsmentioning

confidence: 99%

“…Currently four main types of DCs are recognised: classic DCs, plasmacytoid DCs, Langerhans cells and monocytederived DCs. All these subsets derive from a common myeloid progenitor (Satpathy et al 2012, Pearce & Everts 2015. Classic DCs and monocyte-derived DCs are cells specialized in phagocytosis of pathogens.…”

Section: Dendritic Cellsmentioning

confidence: 99%

“…They are thought to play an important role in the immune response to viruses as they produce large amounts of type 1 interferon upon viral encounter. Langerhans cells are tissue-resident DCs in the skin that resemble tissueresident macrophages in many ways but are also capable of migrating to lymphoid tissues (Satpathy et al 2012, Pearce & Everts 2015.…”

Section: Dendritic Cellsmentioning

confidence: 99%

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Thyroid hormone metabolism in innate immune cells

Spek

Fliers

Boelen

2017

Journal of Endocrinology

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Thyroid hormone (TH) metabolism and thyroid status have been linked to various aspects of the immune response. There is extensive literature available on the effects of thyroid hormone on innate immune cells. However, only recently have authors begun to study the mechanisms behind these effects and the role of intracellular TH metabolism in innate immune cell function during inflammation. This review provides an overview of the molecular machinery of intracellular TH metabolism present in neutrophils, macrophages and dendritic cells and the role and effects of intracellular TH metabolism in these cells. Circulating TH levels have a profound effect on neutrophil, macrophage and dendritic cell function. In general, increased TH levels result in an amplification of the pro-inflammatory response of these cells. The mechanisms behind these effects include both genomic and non-genomic effects of TH. Besides a pro-inflammatory effect induced by extracellular TH, the cellular response to pro-inflammatory stimuli appears to be dependent on functional intracellular TH metabolism. This is illustrated by the fact that the deiodinase enzymes and in some cell types also thyroid hormone receptors appear to be crucial for adequate innate immune cell function. This overview of the literature suggests that TH metabolism plays an important role in the host defence against infection through the modulation of innate immune cell function.

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Section: Dendritic Cellsmentioning

confidence: 99%

Section: Dendritic Cellsmentioning

confidence: 99%

Section: Dendritic Cellsmentioning

confidence: 99%

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Thyroid hormone metabolism in innate immune cells

Spek

Fliers

Boelen

2017

Journal of Endocrinology

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“…Our data demonstrate that acRoots inhibited RARB expression and heterodimer formation, resulting in the disconnection with and accumulations of the retinoid X receptor. The dysfunctional interaction between retinoic acid receptors and retinoid X receptors compromises the recognition and responsiveness to retinoic acid, oxysterols, polyunsaturated and oxidized fatty acids, and 1α,25-dihydroxyvitamin.D3 [19]. However, the complete deletion of RARB gene increased the proliferation of hyposensitive lung cancer cells and the cell sensitivity to acRoots.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

Wang

Hou

Shi

2017

MCT

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Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the antitumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

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“…A nem aktivált dendritikus sejtek a zsírsav-oxidációból biztosítják az oxidatív foszforiláció működését és a glükóz felhasználását. Az utóbbi folyamat útvonala még nem tisztázott ezekben a sejtekben [25,26]. Kimutatott, hogy a dendritikus sejtek -Toll-like receptor-(TLR-) agonistákkal történő -aktivációját követően fokozódik a glükózfelvé-tel és a tejsavtermelés [27].…”

Section: öSszefoglaló Közleményunclassified

A laktátdehidrogenáz (LDH) prognosztikai jelentősége az onkológiában

Deme¹,

Telekes

2017

Orvosi Hetilap

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A rosszindulatú daganatsejtek többségében fokozott a glikolízis, amely biztosítja a proliferációhoz szükséges energia legnagyobb részét. A laktátdehidrogenáz (LDH) anaerob körülmények között katalizálja a reverzibilis piruvát-tejsav átalakulást. A daganatsejtek által expresszált LDHA izoenzim hatására a tejsavképződés jelentősen fokozódik. A tejsav indukálja az oxigenizált daganatsejtek proliferációját, az angiogenezist és gátolja a veleszületett és az adaptív immunválaszt. A szérum-LDH-emelkedés rövidebb túléléssel korrelál. A szerzők áttekintik az LDH-emelkedés és a rosszindulatú daganatos betegségek prognózisa közötti összefüggést feltáró fontosabb vizsgálatokat. Orv Hetil. 2017; 158(50): 1977-1988. Kulcsszavak: laktátdehidrogenáz, rosszindulatú daganatok, prognózis Prognostic importance of lactate dehydrogenase (LDH) in oncologyGlycolysis is increased in most of the malignant cells, providing the largest proportion of energy needed for cell proliferation. Lactate dehydrogenase (LDH) catalyses the reversible process of pyruvate to lactate in anaerobic condition. LDHA isoenzyme expressed mainly by malignant cells, significantly increases lactate formation. Lactate induces the proliferation of oxygenated malignant cells, angiogenesis, and inhibits the innate and adaptive immune responses. Baseline serum LDH elevation correlates with shorter survival. The authors review the relevant studies exploring the correlation between LDH elevation and the prognosis of malignant diseases. Rövidítések A549 = (human non small cell lung cancer cell line A549) humán nem kissejtes tüdőráksejtvonal A549; acetil-CoA = (acetylcoenzyme A) acetil-koenzim A; Acr = activity-regulated cytoskeleton-associated protein; AKT = (protein kinase B) proteinkináz-B; AMP = (adenosine monophosphate) adenozin-monofoszfát; AMPK = (adenosine monophosphate-activated protein kinase) adenozin-monofoszfát aktiválta proteinkináz; ARG1 = (L-arginin metabolizing enzyme arginase-1) L-arginin-metabolizáló enzim argináz-1; ATP = (adenosine triphosphate) adenozin-trifoszfát; CAF = (cancer-associated fibroblasts) daganat asszociálta fibroblastok; CD = (cluster of differentation) differenciációs cluster; CRC = (colorectal cancer) vastag-és végbélrák; CRPC = (castration-resistant prostate cancer) kasztrációrezisztens prostatarák; CSS = (cancer specific survival) daganatspecifikus túlélés; CTL = (cytotoxic T-lymphocyte) citotoxikus T-lymphocyta; DFS = (disease-free survival) betegségmentes túlélés; EGFR = (epidermal growth factor receptor) epidermális növekedési faktor receptor; EpH4 = (nontumorigenic mammary epithelial cells) nem daganatos emlőhámsejt; ER = (estrogen receptor) ösztrogénreceptor; ErbB2 = receptor tyrosine kinase erbB-2 (HER-2/Neu); ERK-2 = (extracellular signal-regulated kinase-2) extracelluláris szignál regulálta kináz 2; FH = (fumarate hydratase) fumaráthidra-táz; c-Fos = Finkel-Biskis-Jinkins-osteosarcoma; FX11 = kis molekulájú LDHA-inhibitor; G6PDH = (glucose-6-phos- Keywords

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Dendritic cell metabolism

Cited by 420 publications

References 122 publications

Thyroid hormone metabolism in innate immune cells

Thyroid hormone metabolism in innate immune cells

Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

A laktátdehidrogenáz (LDH) prognosztikai jelentősége az onkológiában

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