Dendritic cell-mediated cancer immunotherapy with Ecklonia cava fucoidan

Park, Hae‐Bin; Hwang, Juyoung; Lim, Seong-Min; Zhang, Wei; Jin, Jun‐O

doi:10.1016/j.ijbiomac.2020.05.160

Cited by 22 publications

(11 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The weight-average molecular weight of ECF was approximately 42.95 kDa and polydispersity index (PDI) was 1.39 as homogeneity (Table 1). The monosaccharide composition of ECF determined that the major sugar was fucose (45.13%) and galactose (23.24%), whereas xylose (1.78%), glucose (1.37%), and mannose (0.55%) contents constituted a minor component, which was consistent with previous studies [20,41]. Furthermore, Fourier-transform infrared spectroscopy (FT-IR) spectral peaks of ECF revealed that the presence of sulfate groups at 823.51 cm −1 for C-O-S and at 1217.82 cm −1 for S=O (Figure S1).…”

Section: Chemical Analysis Of Ecfsupporting

confidence: 91%

“…Moreover, the ECF showed the most powerful effect in the stimulation of human DCs and T cells than other fucoidans [20]. However, its mucosal immunity is unknown; therefore, in this study, the hypothesis that ECF may be used as a mucosal adjuvant and further exhibits mucosal immunity has been investigated [7,41].…”

Section: Discussionmentioning

confidence: 98%

“…Fucoidans contain various types of monosaccharides such as fucose, xylose, mannose, glucose, and galactose [17,20]. In our previous study, the ECF adjuvant effect in combination with a carcinoma self-antigen has been explored, which protects mice from developing B16 melanoma [41]. The ECF contained higher content of galactose and fucose compared to other fucoidans [20].…”

Section: Discussionmentioning

confidence: 99%

“…As described previously, ECF was purified and isolated [18,20,41]. Briefly, an organic solvent was added to 20 g of dried E. cava for overnight soaking.…”

Section: Preparation Of Ecfmentioning

confidence: 99%

See 3 more Smart Citations

Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer

Zhang

Hwang

Yadav

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on the induction of anti-cancer immunity in the lung was examined by intranasal administration. In C57BL/6 and BALB/c mice, intranasal administration of ECF promoted the activation of dendritic cells (DCs), natural killer (NK) cells, and T cells in the mediastinal lymph node (mLN). The ECF-induced NK and T cell activation was mediated by DCs. In addition, intranasal injection with ECF enhanced the anti-PD-L1 antibody-mediated anti-cancer activities against B16 melanoma and CT-26 carcinoma tumor growth in the lungs, which were required cytotoxic T lymphocytes and NK cells. Thus, these data demonstrated that ECF functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer.

show abstract

Section: Chemical Analysis Of Ecfsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

“…As described previously, ECF was purified and isolated [18,20,41]. Briefly, an organic solvent was added to 20 g of dried E. cava for overnight soaking.…”

Section: Preparation Of Ecfmentioning

confidence: 99%

See 2 more Smart Citations

Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer

Zhang

Hwang

Yadav

et al. 2021

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ag-specific T-cell activation is mediated by macrophages and dendritic cells (DCs). 25 Among them, DCs have the most powerful function of Ag presentation and T-cell activation. 26 Stimulation of pattern recognition receptors (PRRs) promotes the activation of DCs, which upregulates co-stimulator expression.…”

Section: Introductionmentioning

confidence: 99%

Escherichia coliadhesin protein-conjugated thermal responsive hybrid nanoparticles for photothermal and immunotherapy against cancer and its metastasis

Hwang

Zhang

Park

et al. 2021

J Immunother Cancer

Self Cite

View full text Add to dashboard Cite

BackgroundAdvanced cancer therapy is targeted at primary tumors and also recurrent or metastatic cancers. Combinational cancer treatment has recently shown high efficiency against recurrent and metastatic cancers. In this study, we synthesized a thermal responsive hybrid nanoparticle (TRH) containing FimH, an immune stimulatory recombinant protein, for the induction of a combination of photothermal therapy (PTT) and immunotherapy against cancer and its metastasis.MethodsThe hybrid nanoparticle was incorporated with a near-infrared (NIR) absorbent, indocyanine green, and decorated with FimH on its surface to form F-TRH. F-TRH was evaluated for its anticancer and antimetastatic effects against CT-26 carcinoma in mice by combining PTT and immunotherapy.ResultsNIR laser irradiation elicited an elevation of temperature in F-TRH, which induced apoptosis in CT-26 carcinoma cells in vitro. In addition, F-TRH and NIR laser irradiation promoted photothermal-mediated therapeutic effects against CT-26 and 4T1 tumors in mice. The release of FimH from F-TRH in response to elevated temperature and apoptotic bodies of cancer cells via PTT elicited dendritic cell-mediated cancer antigen-specific T-cell responses, which subsequently inhibited the second challenge of CT-26 and 4T1 cell growth in the lung.ConclusionsThese data demonstrate the potential use of F-TRH for immuno-photothermal therapy against cancer and its recurrence and metastasis.

show abstract

Structural characteristics of native and chemically sulfated polysaccharides from seaweed and their antimelanoma effects

Mazepa

Biscaia

Bellan

et al. 2022

Carbohydrate Polymers

View full text Add to dashboard Cite

Dendritic cell-mediated cancer immunotherapy with Ecklonia cava fucoidan

Cited by 22 publications

References 21 publications

Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer

Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer

Escherichia coliadhesin protein-conjugated thermal responsive hybrid nanoparticles for photothermal and immunotherapy against cancer and its metastasis

Structural characteristics of native and chemically sulfated polysaccharides from seaweed and their antimelanoma effects

Contact Info

Product

Resources

About