Dendritic cell lineage, plasticity and cross-regulation

Liu, Yongjun; Kanzler, Holger; Soumelis, Vassili; Gilliet, Michel

doi:10.1038/89726

Cited by 544 publications

(279 citation statements)

References 79 publications

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“…This finding is consistent with the known functional plasticity of myeloid DCs as inducers of both TH1 and TH2 polarization in naı¨ve TH cells (Liu et al, 2001;Lutz and Schuler, 2002). While the IFN-g-positive subset might be relevant in providing help for the induction of cytotoxic T lymphocytes, the IL-4-positive subset indicates a TH2 response to Fbln-1, consistent with a helper activity on antibody production, in agreement with the high antibody response to Fbln-1 found in one of the patients.…”

Section: Discussionsupporting

confidence: 77%

Immunological and pathobiological roles of fibulin-1 in breast cancer

et al. 2003

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Fibulin-1 (Fbln-1) is an immunogenic breast cancerrelated glycoprotein identified by serological analysis of cDNA expression library (SEREX) strategy. Here, we show that dendritic cells from two breast cancer patients elicited a CD4 þ -mediated T-cell response to Fbln-1 presentation. In both patients, an antibody response to Fbln-1 was also found. By contrast, a Fbln-1-seronegative patient and a weakly seropositive patient demonstrated no such T-cell response. Analysis of human breast cancers for Fbln-1 RNA and protein expression revealed the presence of Fbln-1C and -1D variants. Fbln-1 was detected in the cytoplasm and at the cell surface of different human breast carcinoma cell lines. Immunohistochemical analysis of 528 archival primary breast carcinomas showed the expression of Fbln-1 in 35% of the cases. When the immunohistochemical findings were compared against pathobiological information associated with each specimen, an inverse relationship between Fbln-1 and cathepsin D expression was observed (P ¼ 0.04). Furthermore, even though long-term survival was similar between Fbln-1-positive and -negative cases, the survival of Fbln-1-positive cases improved when a lymphoid infiltrate was present at the tumour site. Taken together, our findings of an Fbln-1-specific immunity and the improved survival associated with Fbln-1 expression in the presence of lymphoid infiltration point to a role of Fbln-1 in tumour immunosurveillance.

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Section: Discussionsupporting

confidence: 77%

Immunological and pathobiological roles of fibulin-1 in breast cancer

et al. 2003

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“…As with monocytes, dendritic cells can be derived from either monocyte or lymphoid pathway (Liu et al, 2001).…”

Section: The Development Of T Lymphocytes and B Lymphocytes From Clpsmentioning

confidence: 99%

Hematopoietic cytokines, transcription factors and lineage commitment

2002

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The past two decades have witnessed signi®cant advances in our understanding of the cellular physiology and molecular regulation of hematopoiesis. At the heart of stem cell self-renewal and lineage commitment decisions lies the relative expression levels of lineage-speci®c transcription factors. The expression of these transcription factors in early stem cells may be promiscuous and uctuate, but ultimately comes under the in¯uence of extracellular regulatory signals in the form of hematopoietic cytokines. In this review, we ®rst summarize our current understanding of the phenotypic characterization of hematopoietic stem cells. Next, we describe key known transcription factors which govern stem cell selfrenewal and lineage commitment decisions. Finally, we review data concerning the role of speci®c cytokines in in¯uencing these decisions. From this review, a picture emerges in which stem cell fate decisions are governed by the integrated e ects of intrinsic transcription factors and external signaling pathways initiated by regulatory cytokines.

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“…4). Intracutaneously injected BM-DC may acquire tissue-specific characteristics in the specific microenvironment encountered in skin or skin-draining lymph nodes, enabling them to induce skin-homing T cells, illustrating once again the functional plasticity of DC [156]. …”

Section: Promising New Approaches: Mechanisms Of Skin Homing Of Cd8+ mentioning

confidence: 99%

T Lymphocyte-Mediated Immune Responses to Chemical Haptens and Metal Ions: Implications for Allergic and Autoimmune Disease

Martin¹

2004

Int Arch Allergy Immunol

104

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Chemical haptens and metal ions interact with proteins and thereby become recognizable by T and B lymphocytes. They induce the production of proinflammatory cytokines and chemokines by various cell types due to triggering of innate immune responses. This is an important prerequisite for the activation of the adaptive immune system and the development of diseases like allergic contact dermatitis and adverse drug and autoimmune reactions. Our increasing knowledge about the molecular basis of hapten and metal ion recognition by T cells and about the pathomechanisms of contact hypersensitivity and chemical-induced autoimmune reactions allows concomitant progress in the development of modern strategies for immunotherapy and will hopefully enable more specific intervention in hapten- and metal ion-induced human diseases in the future.

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Dendritic cell lineage, plasticity and cross-regulation

Cited by 544 publications

References 79 publications

Immunological and pathobiological roles of fibulin-1 in breast cancer

Immunological and pathobiological roles of fibulin-1 in breast cancer

Hematopoietic cytokines, transcription factors and lineage commitment

T Lymphocyte-Mediated Immune Responses to Chemical Haptens and Metal Ions: Implications for Allergic and Autoimmune Disease

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