Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation

Sapoznikov, Anita; Kozlovski, Stav; Levi, Nehora; Feigelson, Sara W.; Regev, Ofer; Davidzohn, Natalia; Ben-Dor, Shifra; Haffner-Krausz, Rebecca; Feldmesser, Ester; Wigoda, Noa; Petrovich-Kopitman, Ekaterina; Biton, Moshe; Alon, Ronen

doi:10.1016/j.celrep.2023.112864

Cited by 2 publications

(3 citation statements)

References 68 publications

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“…In this context, there is some controversy about how ICAMs on DCs can regulate T-cell responses. Whereas some studies performed with ICAM-1-deficient mice or ICAM-1-expressing DC-derived exosomes have clearly shown that LFA-1 on either CD4 + or CD8 + T cells and ICAM-1 on DCs are both required for long-lasting cognate T cell-DC interactions and effective T-cell survival and memory [152][153][154], more recent findings reported that productive short-lived interactions between naïve T cells and cognate DCs at early stages of the immune response seem independent of LFA-1 activation [155,156]. These studies suggested that despite strengthening the IS, the interaction between LFA-1 on naïve T cells and ICAM-1 on DCs is not essential for CD4 + and CD8 + T-cell effector functions in vivo, at least upon their respective type 1 helper T cell (Th1)-and type 1 cytotoxic T-cell (Tc1)-polarizing conditions, leaving the door open for a role of the interaction between ICAM-1 and LFA-1 in DC-mediated priming and function of other T-cell subsets.…”

Section: Lfa-1 Signalling By Icam Bindingmentioning

confidence: 99%

ICAMs in Immunity, Intercellular Adhesion and Communication

Guerra-Espinosa,

Jiménez-Fernández,

Sánchez-Madrid

et al. 2024

Cells

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Interactions among leukocytes and leukocytes with immune-associated auxiliary cells represent an essential feature of the immune response that requires the involvement of cell adhesion molecules (CAMs). In the immune system, CAMs include a wide range of members pertaining to different structural and functional families involved in cell development, activation, differentiation and migration. Among them, β2 integrins (LFA-1, Mac-1, p150,95 and αDβ2) are predominantly involved in homotypic and heterotypic leukocyte adhesion. β2 integrins bind to intercellular (I)CAMs, actin cytoskeleton-linked receptors belonging to immunoglobulin superfamily (IgSF)-CAMs expressed by leukocytes and vascular endothelial cells, enabling leukocyte activation and transendothelial migration. β2 integrins have long been viewed as the most important ICAMs partners, propagating intracellular signalling from β2 integrin-ICAM adhesion receptor interaction. In this review, we present previous evidence from pioneering studies and more recent findings supporting an important role for ICAMs in signal transduction. We also discuss the contribution of immune ICAMs (ICAM-1, -2, and -3) to reciprocal cell signalling and function in processes in which β2 integrins supposedly take the lead, paying particular attention to T cell activation, differentiation and migration.

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Section: Lfa-1 Signalling By Icam Bindingmentioning

confidence: 99%

ICAMs in Immunity, Intercellular Adhesion and Communication

Guerra-Espinosa,

Jiménez-Fernández,

Sánchez-Madrid

et al. 2024

Cells

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“…The first signal arises when T cells recognize analogous peptide antigens displayed on the surface of DCs through T cell receptors (TCRs) 61–64 . MHCI molecules bind to CD8 + Tn cells, while MHCII molecules bind to CD4 + Tn cells to present specific antigens to Tn 65 .…”

Section: Crosstalk Between Dcs and T Cellsmentioning

confidence: 99%

“…The first signal arises when T cells recognize analogous peptide antigens displayed on the surface of DCs through T cell receptors (TCRs). [61][62][63][64] MHCI molecules bind to CD8 + Tn cells, while MHCII molecules bind to CD4 + Tn cells to present specific antigens to Tn. 65 The interaction involving MHCs, antigens, and TCRs triggers the activation of T cells, which initiates downstream signals through the immune receptor tyrosine-based activation motif.…”

Section: Dcs Interact With T Cells At the Immune Synapsementioning

confidence: 99%

The DC–T cell axis is an effective target for the treatment of non‐small cell lung cancer

Wang,

Zhang,

Cui

et al. 2023

Immunity Inflam & Disease

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The dendritic cell (DC)‐T cell axis is a bridge that connects innate and adaptive immunities. The initial immune response against tumors is mainly induced by mature antigen‐presenting DCs. Enhancing the crosstalk between DCs and T cells may be an effective approach to improve the immune response to non‐small cell lung cancer (NSCLC). In this article, a review was made of the interaction between DCs and T cells in the treatment of NSCLC and how this interaction affects the treatment outcome.

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Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation

Cited by 2 publications

References 68 publications

ICAMs in Immunity, Intercellular Adhesion and Communication

ICAMs in Immunity, Intercellular Adhesion and Communication

The DC–T cell axis is an effective target for the treatment of non‐small cell lung cancer

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