Dendritic Cell-Based In Situ Nanovaccine for Reprogramming Lipid Metabolism to Boost Tumor Immunotherapy

Qin, You-Teng; Liu, Xin-Hua; An, Jia-Xin; Liang, Jun-Long; Li, Chu-Xin; Jin, Xiao-Kang; Ji, Ping; Zhang, Xian-Zheng

doi:10.1021/acsnano.3c06784

ACS Nano

2023

DOI: 10.1021/acsnano.3c06784

|View full text |Cite

Dendritic Cell-Based In Situ Nanovaccine for Reprogramming Lipid Metabolism to Boost Tumor Immunotherapy

You-Teng Qin,

Xin-Hua Liu,

Jia-Xin An

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 53 publications

(91 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Dual‐Responsive Nanoreactor Initiates In Situ Generation of Copper Complex for Paraptosis‐Mediated Tumor Chemo‐Immunotherapy

Niu,

Li,

Huang

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Paraptosis is a non‐apoptotic and caspase‐independent programmed cell death that can trigger immunogenic cell death (ICD) in tumor cells, representing a potent tactic to overcome immune tolerance to apoptosis. Here, this study demonstrates the construction of a dual‐responsive nanoreactor (MCGDH) to achieve paraptosis‐mediated ICD for chemo‐immunotherapy. Specifically, by doping Cu2+ into glutathione (GSH)‐responsive dendritic mesoporous silica nanoparticles, the platform (CGDMSN) is endowed with partial acid‐sensitivity. After loaded with 8‐hydroxyquinoline (8‐HQ), cell membrane fragments are coated onto the ammoniated CGDMSN surface to construct MCGDH. Upon internalization by tumor cells, the release of Cu2+ and 8‐HQ from MCGDH in response to the acidic pH and high concentration of GSH in the tumor microenvironment stimulates in situ generation of Cu(8‐HQ)2, inducing tumor cells paraptosis at a low copper dose. Moreover, MCGDH‐mediated paraptosis amplifies the immunogenicity of tumor cells, facilitating antigen presentation to dendritic cells and activating CD8+/CD4+ T cells immune responses. Furthermore, the combination of MCGDH and anti‐PD‐1 antibodies (αPD‐1) promotes the systemic anti‐tumor immune responses and long‐term immunological effect to vastly inhibit the primary/distant tumor growth and prevent tumor metastasis. This GSH/pH dual‐responsive nanoreactor serves as a selective platform for accelerating the development of chemo‐immunotherapy.

show abstract

Dual‐Responsive Nanoreactor Initiates In Situ Generation of Copper Complex for Paraptosis‐Mediated Tumor Chemo‐Immunotherapy

Niu,

Li,

Huang

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective

Liu,

Bai,

et al. 2024

eBioMedicine

View full text Add to dashboard Cite

Targeting metabolic pathways to counter cancer immunotherapy resistance

Agarwala,

Brauns,

Sluder

et al. 2024

Trends in Immunology

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Dendritic Cell-Based In Situ Nanovaccine for Reprogramming Lipid Metabolism to Boost Tumor Immunotherapy

Cited by 4 publications

References 53 publications

Dual‐Responsive Nanoreactor Initiates In Situ Generation of Copper Complex for Paraptosis‐Mediated Tumor Chemo‐Immunotherapy

Dual‐Responsive Nanoreactor Initiates In Situ Generation of Copper Complex for Paraptosis‐Mediated Tumor Chemo‐Immunotherapy

Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective

Targeting metabolic pathways to counter cancer immunotherapy resistance

Contact Info

Product

Resources

About