Dendrites and efficiency: Optimizing performance and resource utilization

Makarov, Roman; Pagkalos, Michalis; Poirazi, Panayiota

doi:10.1016/j.conb.2023.102812

Cited by 5 publications

(1 citation statement)

References 67 publications

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“…Accumulating evidence indicates that dendrites do more than merely summate excitatory and inhibitory synaptic inputs [1][2][3][4][5][6] . Dendrites endow neurons with increased computational capacity 7 and the ability to act as multi-level hierarchical networks 8,9 or even to reproduce some features of artificial and deep neural networks 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Supralinear dendritic integration in murine dendrite-targeting interneurons

Griesius,

Richardson,

Kullmann

2024

Preprint

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Non-linear summation of synaptic inputs to the dendrites of pyramidal neurons has been proposed to increase the computation capacity of neurons through coincidence detection, signal amplification, and additional logic operations such as XOR. Supralinear dendritic integration has been documented extensively in principal neurons, mediated by several voltage-dependent conductances. It has also been reported in parvalbumin-positive hippocampal basket cells, although only in dendrites innervated by feedback excitatory synapses. Whether other interneurons, which exclusively support feed-forward inhibition of principal neurons, also exhibit local non-linear integration of synaptic excitation is not known. Here we use patch-clamp electrophysiology, and 2-photon calcium imaging and glutamate uncaging, to show that supralinear dendritic integration of near-synchronous spatially clustered glutamate-receptor mediated depolarization occurs in NDNF-positive neurogliaform cells in the mouse hippocampus. Supralinear summation was detected via recordings of somatic depolarizations elicited by near- synchronous uncaging of glutamate on dendritic fragments, and concurrent imaging of dendritic calcium transients. Supralinearity was abolished by blocking NMDA receptors (NMDARs) but resisted blockade of voltage-gated sodium channels. Blocking L-type calcium channels abolished supralinear calcium signalling but only had a minor effect on voltage supralinearity. Dendritic boosting of spatially clustered synaptic signals argues for previously unappreciated computational complexity in neurogliaform cells.

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Section: Introductionmentioning

confidence: 99%

Supralinear dendritic integration in murine dendrite-targeting interneurons

Griesius,

Richardson,

Kullmann

2024

Preprint

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Editorial overview: Computational neuroscience as a bridge between artificial intelligence, modeling and data

Verzelli,

Tchumatchenko,

Kotaleski

2024

Current Opinion in Neurobiology

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Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

Richevaux

Lim

Nassar

et al. 2023

Preprint

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Head-direction (HD) signals function as the brain's internal compass. They are organized as an attractor, and anchor to the environment via visual landmarks. This association might happen in the dorsal presubiculum. We find converging monosynaptic excitatory connections from anterior thalamic nucleus and from retrosplenial cortex on single layer 3 presubicular neurons. Independent dual wavelength photostimulation of these inputs in slices leads to action potential generation preferentially for near-coincident inputs, sending an integrated HD signal to medial entorhinal cortex. Layer 4 neurons send their axons to the lateral mammillary nucleus. However, their dendrites avoid overlap with thalamic and retrosplenial axons. Action potentials in layer 4 neurons may be initiated following di-synaptic excitation via layer 3, indicating that landmark updating of HD signals in the lateral mammillary nucleus is a two-step process. Thus, a coherent sense of orientation involves projection specific translaminar processing in the presubiculum.

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Dendrites and efficiency: Optimizing performance and resource utilization

Cited by 5 publications

References 67 publications

Supralinear dendritic integration in murine dendrite-targeting interneurons

Supralinear dendritic integration in murine dendrite-targeting interneurons

Editorial overview: Computational neuroscience as a bridge between artificial intelligence, modeling and data

Projection-specific integration of convergent thalamic and retrosplenial signals in the presubicular head direction cortex

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