Dendrimers: Potential Drug Carrier For Novel Drug Delivery System

Kumar, Inder; Dhiman, Sunny; Palia, Priyankul; Kumar, Pankaj; Sharma, Neeraj

doi:10.22270/ajprd.v9i2.945

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…But for most skin treatments, they just need to get through the outermost layer, the stratum corneum, and stay in the skin layers to work effectively. 18…”

Section: Subcutaneous Tissue (Hypodermis)mentioning

confidence: 99%

A review on transdermal drug delivery through patches

Srivastava,

Shaikh

2024

IJCED

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A transdermal drug delivery system (TDDS) falls under the controlled drug delivery category, aiming to administer drugs through the skin at a predetermined and controlled rate. This approach presents numerous benefits, such as extended therapeutic impact, reduced adverse effects, increased bioavailability, enhanced patient adherence, and convenient discontinuation of medication. The outermost layer of the skin, the stratum corneum, plays a key role in controlling the transdermal penetration of most substances. Three main routes facilitate drug penetration: appendageal, transcellular, and intercellular. When administering drugs through this pathway, it is essential to consider diverse factors, including the age and condition of the skin, physicochemical properties, and environmental influences. Crucial elements of Transdermal Drug Delivery Systems (TDDS) include a polymer matrix, membrane, drug, penetration enhancers, pressure-sensitive adhesives, backing laminates, and a release liner. Transdermal patches fall into categories such as reservoir systems, matrix systems, and micro- reservoir systems, all specifically engineered to introduce active ingredients into the circulatory system via the skin. A standardized approach is utilized to evaluate various aspects, including adhesion properties, in vitro drug release and stability. The purpose of reviewing the topic of transdermal drug delivery system through patches is to comprehensively evaluate the advancements, challenges, and potential applications of this innovative drug delivery method.

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“…But for most skin treatments, they just need to get through the outermost layer, the stratum corneum, and stay in the skin layers to work effectively. 18…”

Section: Subcutaneous Tissue (Hypodermis)mentioning

confidence: 99%

A review on transdermal drug delivery through patches

Srivastava,

Shaikh

2024

IJCED

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“…For the swelling index, 50 mg of microsomes were placed in water and set aside to swell overnight, filtered, and weight, the degree of swelling is calculated by [18,19] Swelling index a Weight of swelled microsomes Wg…”

Section: Swelling Indexmentioning

confidence: 99%

Untitled

2023

AJP

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Objective: Acyclovir (ACV), a highly specific inhibitor of herpes virus replication, is applied topically into the eye to treat ocular keratitis. The main aim of this study was to formulate and characterize eye drops containing ACV microspheres against herpes simplex-induced keratitis. The microspheres are small spherical particles with diameters ranging from 10 to 1000 μm. It increases bioavailability while decreasing side effects. Materials and Methods:The solvent evaporation technique was used to develop the microspheres for the sustained release drug delivery system. Crystalline methylcellulose, sodium alginate, calcium chloride, and chitosan were the polymers used. The drug content, encapsulation efficiency, in vitro drug release studies, stability studies, viscosity, pH measurement, and clarity test were all performed on the microspheres. Results: Particle size and shape, percent entrapment, in vitro drug release, compatibility studies, and other characteristics of microsomes were assessed. These drug delivery systems demonstrated good increased solubility and sustained release, which is necessary for bioavailability and therapeutic action, due to their matrix nature. The formulation has an acceptable shape and particle size, no chemical interactions, and is stable under refrigeration, according to the results of the characterization parameters and stability research. Conclusion: Eye drops containing microspheres of ACV could be considered a promising sustained drug delivery system for ocular keratitis treatment.

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