Dendrimers for Drug Delivery

Chauhan, Abhay Singh

doi:10.3390/molecules23040938

Cited by 303 publications

(169 citation statements)

References 18 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…administration, such as through the use of nanoparticles and dendrimers, might enable i.v. use in the future (61,62). Dendrimers in particular have already successfully been used to intravenously administer LF for the treatment of cancer cells in mice (63).…”

Section: Discussionmentioning

confidence: 99%

Lactoferrin Is Broadly Active against Yeasts and Highly Synergistic with Amphotericin B

Fernandes

Weeks

Carter

2020

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Lactoferrin (LF) is a multifunctional milk protein with antimicrobial activity against a range of pathogens. While numerous studies report that LF is active against fungi, there are considerable differences in the level of antifungal activity and the capacity of LF to interact with other drugs. Here we undertook a comprehensive evaluation of the antifungal spectrum of activity of three defined sources of LF across 22 yeast and 24 mold species and assessed its interactions with six widely used antifungal drugs. LF was broadly and consistently active against all yeast species tested (MICs, 8 to 64 μg/ml), with the extent of activity being strongly affected by iron saturation. LF was synergistic with amphotericin B (AMB) against 19 out of 22 yeast species tested, and synergy was unaffected by iron saturation but was affected by the extent of LF digestion. LF-AMB combination therapy significantly prolonged the survival of Galleria mellonella wax moth larvae infected with Candida albicans or Cryptococcus neoformans and decreased the fungal burden 12- to 25-fold. Evidence that LF directly interacts with the fungal cell surface was seen via scanning electron microscopy, which showed pore formation, hyphal thinning, and major cell collapse in response to LF-AMB synergy. Important virulence mechanisms were disrupted by LF-AMB treatment, which significantly prevented biofilms in C. albicans and C. glabrata, inhibited hyphal development in C. albicans, and reduced cell and capsule size and phenotypic diversity in Cryptococcus. Our results demonstrate the potential of LF-AMB as an antifungal treatment that is broadly synergistic against important yeast pathogens, with the synergy being attributed to the presence of one or more LF peptides.

show abstract

Section: Discussionmentioning

confidence: 99%

Lactoferrin Is Broadly Active against Yeasts and Highly Synergistic with Amphotericin B

Fernandes

Weeks

Carter

2020

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

“…The PAMAM dendrimer is the most well-studied and well-characterized class of dendrimers and was the first dendrimer that was synthesized and commercialized. For these reasons, this dendrimer has several medicinal and practical applications [27]. In the next sections, some applications of PAMAM and other dendrimers as drug-delivery systems will be mentioned.…”

Section: Application Of Dendrimers As Drug-delivery Systemsmentioning

confidence: 99%

“…The constitution of the dendrimer may confer different activities, namely, anti-inflammatory activity, antiviral activity and antimicrobial activity [13,15]. As a pharmaceutical excipient, dendrimers may enhance distinct properties of the formulation according to the phase of drug product development [27].…”

Section: Introductionmentioning

confidence: 99%

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

View full text Add to dashboard Cite

The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer’s properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.

show abstract

“…Due to their significance in the field of medicine, dendrimers have been studied intensively in the past few years, and because of the extensive number of studies performed regarding this subject, review articles that emphasize several aspects have been published. A great interest has been shown in the biomedical applications of dendrimers, especially for their capacity to be used as targeted drug [ 7 , 14 , 15 , 16 ] and gene delivery systems [ 17 , 18 , 19 ]. Advances in diagnostics that use imaging techniques were made [ 20 , 21 , 22 ], along with the improvement of treatments for diseases like cancer [ 23 , 24 , 25 , 26 ], cardio-vascular diseases [ 27 ], inflammatory diseases [ 26 , 28 , 29 ], and viral and bacterial infections [ 26 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

View full text Add to dashboard Cite

Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due to their capacity for improving solubility, absorption, bioavailability and targeted distribution. Molecular cytotoxicity constitutes a limiting characteristic, especially for cationic and higher-generation dendrimers. Antineoplastic research of dendrimers has been widely developed, and several types of poly(amidoamine) and poly(propylene imine) dendrimer complexes with doxorubicin, paclitaxel, imatinib, sunitinib, cisplatin, melphalan and methotrexate have shown an improvement in comparison with the drug molecule alone. The anti-inflammatory therapy focused on dendrimer complexes of ibuprofen, indomethacin, piroxicam, ketoprofen and diflunisal. In the context of the development of antibiotic-resistant bacterial strains, dendrimer complexes of fluoroquinolones, macrolides, beta-lactamines and aminoglycosides have shown promising effects. Regarding antiviral therapy, studies have been performed to develop dendrimer conjugates with tenofovir, maraviroc, zidovudine, oseltamivir and acyclovir, among others. Furthermore, cardiovascular therapy has strongly addressed dendrimers. Employed in imaging diagnostics, dendrimers reduce the dosage required to obtain images, thus improving the efficiency of radioisotopes. Dendrimers are macromolecular structures with multiple advantages that can suffer modifications depending on the chemical nature of the drug that has to be transported. The results obtained so far encourage the pursuit of new studies.

show abstract

Dendrimers for Drug Delivery

Cited by 303 publications

References 18 publications

Lactoferrin Is Broadly Active against Yeasts and Highly Synergistic with Amphotericin B

Lactoferrin Is Broadly Active against Yeasts and Highly Synergistic with Amphotericin B

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

Applications and Limitations of Dendrimers in Biomedicine

Contact Info

Product

Resources

About