Dendrimers as novel drug-delivery system and its applications

Patel, Vruti; Rajani, Chitra; Paul, Debleena; Borisa, Pooja; Rajpoot, Kuldeep; Youngren-Ortiz, Susanne R.; Tekade, Rakesh K.

doi:10.1016/b978-0-12-814487-9.00008-9

Cited by 29 publications

(10 citation statements)

References 150 publications

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“…Whereas G n -[Cu(ONO 2 ) 2 ] m dendriplexes appeared inside cells as green dots, the complexes created with G n -[CuCl 2 ] m were mainly near the cell membranes, rarely in the cytoplasm ( Figure 8 , top panels). Although transfection will depend on the type of cell to be transfected, the applied dendrimer generation, and the time of incubation, we can say that copper (II) metallodendrimers, in general, have a greater transfection efficiency than the Ru(II) analogues in the HL60 a cell line (Ru(II)-second generation (≈30% efficiency) [ 12 ], and close to cationic carbosilane dendrimers with 16 positive charges on the surface [ 5 ]. The extension of incubation time up to 24 h can cause a gradual siRNA release from the complex, and, as a result, the siRNA interference phenomenon may be initiated [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…For example, mesoporous silica nanoparticles that incorporate folic acid promoting endocytosis [ 10 ] or amphiphilic dendrimer with RGDK peptide sequences [ 11 ] have been described as efficient vectors for transfection of various siRNAs. Dendrimers are monodisperse materials that have interesting properties that can be used in different biomedical fields and have proved useful transfecting agent [ 12 ]. The possibility of incorporating different therapeutic fragments in a controlled way to dendritic scaffold opens the door to use heterofunctional systems with different modes of action.…”

Section: Introductionmentioning

confidence: 99%

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Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

et al. 2020

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Cancer treatment with small interfering RNA (siRNA) is one of the most promising new strategies; however, transfection systems that increase its bioavailability and ensure its delivery to the target cell are necessary. Transfection systems may be just vehicular or could contain fragments with anticancer activity that achieves a synergistic effect with siRNA. Cationic carbosilane dendrimers have proved to be powerful tools as non-viral vectors for siRNA in cancer treatment, and their activity might be potentiated by the inclusion of metallic complexes in its dendritic structure. We have herein explored the interaction between Schiff-base carbosilane copper (II) metallodendrimers, and pro-apoptotic siRNAs. The nanocomplexes formed by metallodendrimers and different siRNA have been examined for their zeta potential and size, and by transmission electron microscopy, fluorescence polarisation, circular dichroism, and electrophoresis. The internalisation of dendriplexes has been estimated by flow cytometry and confocal microscopy in a human breast cancer cell line (MCF-7), following the ability of these metallodendrimers to deliver the siRNA into the cell. Finally, in vitro cell viability experiments have indicated effective interactions between Cu (II) dendrimers and pro-apoptotic siRNAs: Mcl-1 and Bcl-2 in breast cancer cells. Combination of the first-generation derivatives with chloride counterions and with siRNA increases the anticancer activity of the dendriplex constructs and makes them a promising non-viral vector.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

et al. 2020

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“…Dendrimers are also studied as DDS in other therapeutic fields: anti-inflammatory, antiviral, antibiotic therapies, and in cardiovascular diseases, etc. [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

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Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due to their capacity for improving solubility, absorption, bioavailability and targeted distribution. Molecular cytotoxicity constitutes a limiting characteristic, especially for cationic and higher-generation dendrimers. Antineoplastic research of dendrimers has been widely developed, and several types of poly(amidoamine) and poly(propylene imine) dendrimer complexes with doxorubicin, paclitaxel, imatinib, sunitinib, cisplatin, melphalan and methotrexate have shown an improvement in comparison with the drug molecule alone. The anti-inflammatory therapy focused on dendrimer complexes of ibuprofen, indomethacin, piroxicam, ketoprofen and diflunisal. In the context of the development of antibiotic-resistant bacterial strains, dendrimer complexes of fluoroquinolones, macrolides, beta-lactamines and aminoglycosides have shown promising effects. Regarding antiviral therapy, studies have been performed to develop dendrimer conjugates with tenofovir, maraviroc, zidovudine, oseltamivir and acyclovir, among others. Furthermore, cardiovascular therapy has strongly addressed dendrimers. Employed in imaging diagnostics, dendrimers reduce the dosage required to obtain images, thus improving the efficiency of radioisotopes. Dendrimers are macromolecular structures with multiple advantages that can suffer modifications depending on the chemical nature of the drug that has to be transported. The results obtained so far encourage the pursuit of new studies.

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“…Subsequently these dendrimers are regularly utilized in various biomedical applications like drug solubilization, as drug delivery, as MRI differentiate operators and so many more [20]. Utilization of dendrimer as a vehicle for tranquilize conveyance has been of incredible intrigue [21][22][23].…”

Section: Fig 1 Glyburide (Glb)mentioning

confidence: 99%

Triazine Dendrimers: An Excellent Drug Carrier for Improving the Solubility of Glyburide an Antidiabetic Agent

Malek¹,

Patel²

2022

Preprint

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The intent of this work was to synthesized, develop and characterize a novel dendrimer and drug-dendrimer solutions to resolve poorly aqueous solubility of glyburide which is an antidiabetic BSC class-II drug’s problem. Drug- dendrimer complex formation is one of the widely reported method for solubility enhancement of the drug which can increase the efficiency of the drug. A number of glyburide drug solutions were formulated with different quantities of G1, G2 and G3 dendrimers via Higuchi and Connors method. The effects of pH, dendrimer concentration and generation of dendrimers (G1-G3) on the aqueous solubility of drug was investigated and characterized by FT-IR, NMR ( 1 H and 13 C). The experimental outcomes recommended that solubility of glyburide was significantly enhanced with the increasing concentration of dendrimers as well as the generations of dendrimers.

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Dendrimers as novel drug-delivery system and its applications

Cited by 29 publications

References 150 publications

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

Applications and Limitations of Dendrimers in Biomedicine

Triazine Dendrimers: An Excellent Drug Carrier for Improving the Solubility of Glyburide an Antidiabetic Agent

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