Dendrimers as Drug Carriers: Dynamics of PEGylated and Methotrexate-Loaded Dendrimers in Aqueous Solution

Natali, Sanja; Mijović, Jovan

doi:10.1021/ma902670q

Cited by 9 publications

(6 citation statements)

References 37 publications

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“…This class of biopolymers is also concerned by the previously mentioned general trends. Some successful attempts undertaken to design new dendritic polypeptide-like molecules as well as other water soluble dendrimers (for instance well-known poly(amido amine) (PAMAM)) had demonstrated the benefits of turning the shape and surface properties of such structurally ordered macromolecules [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide

et al. 2012

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Abstract:The four first generations of dendrigraft poly-L-lysine have been studied in dimethylformamide (aprotic solvent) and in 0.2 M NaCl aqueous solutions by isothermal translation diffusion, 1 H NMR and viscometry methods. The relationships between diffusion coefficient, intrinsic viscosity and molar mass have been determined for dendrigraft poly-L-lysines, and the scaling index values have been compared to classical trifunctional dendrimers. Dendrimers and dendrigraft poly-L-lysines exhibited similitudes in their hydrodynamic behaviors. Nevertheless, dendrigraft poly-L-lysines displayed a specific behavior in solution. In contrast to dendrimers, a significant change of hydrodynamic dimension of dendrigraft poly-L-lysines according to the nature of the solvent has been observed. In aprotic solvent, the dendrigraft poly-L-lysine dimensions are about two times lower than in aqueous media (i.e., the hydrodynamic volume is contracted by a factor 8 in dimethylformamide), revealing the softness of dendrigraft poly-L-lysine compared to classical trifunctional dendrimers. OPEN ACCESSPolymers 2012, 4 21

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Section: Introductionmentioning

confidence: 99%

Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide

et al. 2012

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“…PEO, as a water-soluble polymer, was also used in the pharmaceutical field. It was reported that the encapsulation efficiency increased and the release rate was slowed down by attaching PEO chains. − To decrease water solubility of PAA, novel interpolymer complexes of PAA and methoxy PEO with various molecular weights and compositions, which can promote the adhesive process and slow down the dissolution rate, were prepared. − Therefore, it is important to obtain the internal dynamics in PAA- g -PEO solution for its potential application. The interchain interaction of PAA- g -PEO in aqueous solution has been investigated using laser light scattering (LLS), viscometry, and rheological measurements .…”

Section: Introductionmentioning

confidence: 99%

Effects of Concentration and Temperature on the Dynamic Behavior of PAA-g-PEO Aqueous Solutions with Different Counterion Species: A Dielectric Spectroscopy Study

Liu

Zhao

2012

J. Phys. Chem. B

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Dielectric properties of PAA-g-PEO-7% solutions with different counterions were measured as a function of concentration and temperature over a frequency range of 40 Hz to 110 MHz. After the contribution of electrode polarization effects was subtracted, the dielectric spectra of PAA-g-PEO-7% solutions showed three relaxation processes in the experimental frequency range, named low-, mid-, and high-frequency relaxation. The observed three relaxations were strictly analyzed by using the Cole-Cole relaxation function, and the dielectric parameters (dielectric increment Δε and the relaxation time τ) were obtained. The scaling relation of dielectric increment and relaxation time of high frequency with concentration C(p) were obtained and compared with the predictions of scaling theories. The information on the dynamics and microstructure of PAA-g-PEO-7% was obtained. Using different counterion species, the mid- and high-frequency relaxation mechanisms were attributed to the fluctuation of condensed counterions and free counterions, respectively, and the low-frequency relaxation was considered to be caused by the interface polarization of a complex formed by the hydrogen bonding between carboxylic group of PAA and ether oxygen on the side-chain PEO. In addition, by means of Eyring equation, the thermodynamic parameters, enthalpy change ΔH and entropy change ΔS, of the three relaxations were calculated from the relaxation time and discussed from the microscopic thermodynamical view.

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“…Therefore, a proper modification of dendrimer ends could consist of attaching end groups that are (highly) incompatible with the “main dendrimer”. For instance, in PEGylated dendrimers, there are virtually no contacts between terminal polyethylene glycol (PEG) spacers and the dendrimer interior, and this dendrimer has a good perspective of practical applications for drug delivery …”

Section: Introductionmentioning

confidence: 99%

“…For instance, in PEGylated dendrimers, there are virtually no contacts between terminal polyethylene glycol (PEG) spacers and the dendrimer interior, 22 and this dendrimer has a good perspective of practical applications for drug delivery. 23 The properties of the G = 4 generation carbosilane dendrimer with terminal cyanobiphenyl mesogenic groups in dilute chloroform solution were studied in ref 24 at different temperatures. Comparison of the mobility of terminal and inner CH 3 groups at 300 K and lower temperatures allowed the authors to suggest that the density in the dendrimer interior is lower than that at the periphery.…”

Section: Introductionmentioning

confidence: 99%

Formation of a “Hollow” Interior in the Fourth-Generation Dendrimer with Attached Oligomeric Terminal Segments

Markelov¹,

Polotsky²,

Birshtein³

2014

J. Phys. Chem. B

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By using the Scheutjens-Fleer self-consistent field approach, the structure of the fourth-generation dendrimer with attached terminal chemically different oligomeric segments is studied theoretically. It is demonstrated that an incompatibility of terminal segments with inner dendrimer units leads to formation of a "hollow" core with reduced polymer density in the dendrimer center. This effect is enhanced with a deterioration in the solvent quality for terminal segments. This observation is in accordance with experimental results and molecular dynamics simulation data for an analogous system. It is established that the main factor determining the hollow core formation is the segregation between inner and terminal units because the main driving force for the effect is the localization of the terminal segments at the dendrimer periphery. The influence of structural parameters of dendrimer such as the number of generations and length of the terminal chain on this effect is also studied.

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Dendrimers as Drug Carriers: Dynamics of PEGylated and Methotrexate-Loaded Dendrimers in Aqueous Solution

Cited by 9 publications

References 37 publications

Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide

Hydrodynamic Behavior of Dendrigraft Polylysines in Water and Dimethylformamide

Effects of Concentration and Temperature on the Dynamic Behavior of PAA-g-PEO Aqueous Solutions with Different Counterion Species: A Dielectric Spectroscopy Study

Formation of a “Hollow” Interior in the Fourth-Generation Dendrimer with Attached Oligomeric Terminal Segments

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