Dendrimers as carriers for active targeting of brain tumors

Jose, Jobin; Bandiwadekar, Akshay; Figreda, Glain Gloria; Crasta, Cleril Macqwin

doi:10.1016/b978-0-323-90773-6.00001-4

Cited by 2 publications

(1 citation statement)

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“…These are crucial tools for treating brain tumors due to their many properties, including physicochemical characteristics, composition, and surface functionality, that can be altered for active targeting. Dendrimers show great potential for treating brain cancers due to their capacity to deliver molecular payloads to tumor sites and their effectiveness in permeating the BBB and entering the brain [ 116 ]. Interestingly, intranasal administration enables undeviating drug deliverance into the brain without bridging the BBB.…”

Section: Organic Nanocarriersmentioning

confidence: 99%

Targeting brain tumors with innovative nanocarriers: bridging the gap through the blood-brain barrier

WADHWA,

CHAUHAN,

KUMAR

et al. 2024

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Background Glioblastoma multiforme (GBM) is recognized as the most lethal and most highly invasive tumor. The high likelihood of treatment failure arises from the presence of the blood-brain barrier (BBB) and stem cells around GBM, which avert the entry of chemotherapeutic drugs into the tumor mass. Objective Recently, several researchers have designed novel nanocarrier systems like liposomes, dendrimers, metallic nanoparticles, nanodiamonds, and nanorobot approaches, allowing drugs to infiltrate the BBB more efficiently, opening up innovative avenues to prevail over therapy problems and radiation therapy. Methods Relevant literature for this manuscript has been collected from a comprehensive and systematic search of databases, for example, PubMed, Science Direct, Google Scholar, and others, using specific keyword combinations, including “glioblastoma,” “brain tumor,” “nanocarriers,” and several others. Conclusion This review also provides deep insights into recent advancements in nanocarrier-based formulations and technologies for GBM management. Elucidation of various scientific advances in conjunction with encouraging findings concerning the future perspectives and challenges of nanocarriers for effective brain tumor management has also been discussed.

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Section: Organic Nanocarriersmentioning

confidence: 99%