Dendrimers as Antibacterial Agents

Tülü, Metin; Ertürk, Ali

doi:10.5772/46051

Cited by 12 publications

(5 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature reveals that dendrimers themselves have been found to be effective antibacterials, which prompted many scientists to focus on synthesizing antibacterial dendrimers. The details of these antibacterial dendrimers are out of the scope of this review and can be found elsewhere . The following sections, therefore, only highlights the use of dendrimers to enhance the properties of antibiotics via nanostructures.…”

Section: Nanoengineered Antibiotic Delivery Systemsmentioning

confidence: 99%

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Kalhapure

Suleman

Mocktar

et al. 2015

Journal of Pharmaceutical Sciences

173

105

View full text Add to dashboard Cite

Section: Nanoengineered Antibiotic Delivery Systemsmentioning

confidence: 99%

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Kalhapure

Suleman

Mocktar

et al. 2015

Journal of Pharmaceutical Sciences

173

105

View full text Add to dashboard Cite

“…-NH2), the resulting interaction can alter membrane permeability. In some cases, this can lead to a bactericidal effect through membrane disintegration [18].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Some Nano-Antimicrobial Poly(amidoamine) (Pamam) Dendrimeric Products

Caracoti

Negrea

Florea³

2021

Roum Arch Microbiol Immunol

View full text Add to dashboard Cite

"Dendrimers are synthetic, branched macromolecules. Compared to linear polymers, dendrimers hold multiple advantages as potential carrier molecules: high capacity to incorporate pharmacologically active substances, chemical stability of micelles under physiological conditions, increased bioavailability of active substances covalently or noncovalently bound to dendrimers, due to increased dendrimers capacity to cross biological barriers. The carrier potential of dendrimers has been evaluated in combination with different antibiotics, as an alternative way to address the increasing resistance of Gram-positive and Gram-negative bacteria. This paper presents a study on the intrinsic antibacterial properties of the following poly(amidoamino) (PAMAM) ethylenediamine core dendrimers: PAMAM generation 3.5, PAMAM generation 4.0 and PAMAM-OH generation 4.0. The following bacterial strains were used: Staphylococcus aureus ATCC 29213, Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 15442, Enterococcus faecalis ATCC 51299 and a multi-drug resistant (MDR) Acinetobacter baumannii clinical isolate. The dendrimers’ concentrations used in the experiment were established within the range of admissibility obtained following cytotoxicity testing on human cell cultures. The dendrimers’ antibacterial activity varied depending on the concentration and the bacterial species. The antibacterial efficacy was quantified by calculating the percentage and logarithmic reduction of the number of viable microorganisms. The logarithmic reduction varied between 0.06 and 1.10, corresponding to percentage reductions between 13% and 92%. The strongest antibacterial activity of all dendrimers used in this study was registered for the D3.5 dendrimer (50 μg/mL) against Acinetobacter baumannii and Pseudomonas aeruginosa ATCC 15442 reference strain. For A. baumannii, a logarithmic reduction of bacterial activity of 1.10 log10 (percentage reduction in the number of CFU of 92%) was registered, while for P. aeruginosa ATCC 15442 the logarithmic reduction was 0.75 log10 (percentage reduction of 82%)."

show abstract

“…Terpenoids are known to be effective in inhibiting bacterial growth. The antibacterial mechanism of terpenoids is the breakdown of membranes involving lipophilic components 13 . Triterpenoids interfere with transmembrane proteins (called porins) in the outer membrane of bacterial cells, with the consequence of disrupting cell wall permeability and reducing cell nutrition, leading to bacterial cell death 14 .…”

Section: Discussionmentioning

confidence: 99%

Effect of White Oyster Mushroom (Pleurotus ostreatus) Ethanol Extract on Bacillus subtilis Bacteria

Handrianto,

Ratnasari

2021

MIDPRO

View full text Add to dashboard Cite

The increasing number of infectious diseases caused by bacteria, fungi, viruses and parasites in Indonesia, and one of the bacteria that causes this disease is Bacillus subtilis. Therefore, the role of antibacterial is very important for the treatment of this disease. One of the antibacterials from nature is the white oyster mushroom (Pleurotus ostreatus). The purpose of this study was to determine the effect of various concentrations of white oyster mushroom (Pleurotus ostreatus) extract which was effective as an antibacterial against Bacillus subtilis. The research method uses the paper disc diffusion method. The results showed that the bacterial inhibition zone at a concentration of 20 g/ml obtained an average of 9.5 mm in the medium category, a concentration of 40 g/ml obtained an average of 11.3 mm in the strong category, a concentration of 60 g/ml obtained an average of 13, 3 mm in the strong category, a concentration of 80 g/ml obtained an average of 15.5 mm in the strong category and a concentration of 100 g/ml obtained an average of 17.3 mm in the strong category. The conclusion of this research is white oyster mushroom can be used as an anti-bacterial for Bacillus subtilis.

show abstract

Dendrimers as Antibacterial Agents

Cited by 12 publications

References 62 publications

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Nanoengineered Drug Delivery Systems for Enhancing Antibiotic Therapy

Antibacterial Activity of Some Nano-Antimicrobial Poly(amidoamine) (Pamam) Dendrimeric Products

Effect of White Oyster Mushroom (Pleurotus ostreatus) Ethanol Extract on Bacillus subtilis Bacteria

Contact Info

Product

Resources

About