Dendrimers and dendritic nanoparticles for stimuli-responsive nanomedicine

Poellmann, Michael J.; Javius-Jones, Kaila; Nair, Ashita; Hong, Seungpyo

doi:10.1016/b978-0-12-824456-2.00003-5

Cited by 2 publications

(3 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…80 The superior capability of the G3 dLNPs was owed to its heightened proton buffering capacity, allowing efficient endosomal escape compared to their G2 counterparts. 80,95 Other investigators also confirmed that higher generation dendritic NPs offer optimal drug delivery results. 96,97…”

Section: Dendritic Lnps (Dlnps)mentioning

confidence: 85%

Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy

Kim,

Javius-Jones,

Mamidi

et al. 2024

Nanoscale

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Dendritic Lnps (Dlnps)mentioning

confidence: 85%

Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy

Kim,

Javius-Jones,

Mamidi

et al. 2024

Nanoscale

Self Cite

View full text Add to dashboard Cite

show abstract

“…Finally, the high density of well-ordered functional groups afforded by dendrimers and dendrons opens the door to dramatic stimuli-responsive behavior when stimuli-responsive elements are incorporated at branch ends. 85 Common elements employed in nanomedicines will degrade in response to a low pH or the presence of specific enzymes present in endosomes. As it is increasingly recognized that nanoparticle transport into tumors is primarily through intracellular routes, 86 this sort of stimuli-responsive behavior may greatly improve the delivery efficiency.…”

Section: ■ Dendron Micelles In Cancer Drug Loading Transport Targetin...mentioning

confidence: 99%

Section: Dendron Micelles In Cancer Drug Loading Transport Targeting ...mentioning

confidence: 99%

Dendritic–Linear Copolymer and Dendron Lipid Nanoparticles for Drug and Gene Delivery

et al. 2022

Self Cite

View full text Add to dashboard Cite

Polymers constitute a diverse class of macromolecules that have demonstrated their unique advantages to be utilized for drug or gene delivery applications. In particular, polymers with a highly ordered, hyperbranched structure“dendrons”offer significant benefits to the design of such nanomedicines. The incorporation of dendrons into block copolymer micelles can endow various unique properties that are not typically observed from linear polymer counterparts. Specifically, the dendritic structure induces the conical shape of unimers that form micelles, thereby improving the thermodynamic stability and achieving a low critical micelle concentration (CMC). Furthermore, through a high density of highly ordered functional groups, dendrons can enhance gene complexation, drug loading, and stimuli-responsive behavior. In addition, outward-branching dendrons can support a high density of nonfouling polymers, such as poly(ethylene glycol), for serum stability and variable densities of multifunctional groups for multivalent cellular targeting and interactions. In this paper, we review the design considerations for dendron–lipid nanoparticles and dendron micelles formed from amphiphilic block copolymers intended for gene transfection and cancer drug delivery applications. These technologies are early in preclinical development and, as with other nanomedicines, face many obstacles on the way to clinical adoption. Nevertheless, the utility of dendron micelles for drug delivery remains relatively underexplored, and we believe there are significant and dramatic advancements to be made in tumor targeting with these platforms.

show abstract

Dendrimers and dendritic nanoparticles for stimuli-responsive nanomedicine

Cited by 2 publications

References 81 publications

Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy

Dendritic nanoparticles for immune modulation: a potential next-generation nanocarrier for cancer immunotherapy

Dendritic–Linear Copolymer and Dendron Lipid Nanoparticles for Drug and Gene Delivery

Contact Info

Product

Resources

About