Dendrimers

Malkoch, Michael; Malmström, Eva; Nyström, Andreas M.

doi:10.1016/b978-0-444-53349-4.00162-x

Cited by 18 publications

(11 citation statements)

References 412 publications

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“…Therefore, highly branched dendrimers are favored both spatially and energetically [31] . The target specificity of the dendrimers can be significantly improved by introducing certain sensors [63] . For eg, DOX was attached to a PEGylated peptide based dendrimer surface via tetra peptide linker of the sequence Gly−Phe−Leu−Gly (GFLG).…”

Section: Types Of Polymer Nanocarriersmentioning

confidence: 99%

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Chakraborty,

Meher,

Dash

et al. 2023

ChemistrySelect

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The last decade has seen a meteoric rise in studies investigating polymeric aggregates as nanocarriers. When it comes to morphology, size, functionality, and immunostability, polymeric nanocarriers (PNCs) are unparalleled. With characteristics such as large surface area to volume ratio, amphiphilic nano‐environment, non‐toxic components, chemically modifiable composition, external surface alteration potential, uniform particle size, and stimuli‐dependent self‐assembly, PNCs have emerged as strong candidates for therapeutic applications. The article reviews the latest research on different challenges and strategies for targeted drug delivery and shall serve as guide to the researchers in designing site‐specific nanocarriers for application in future. The review systematically discusses the fundamental structural variation of the nanocarriers with emphasis on the influence of chemical alterations and the resulting effects on functionality; addresses the difficulties encountered with modes of administration; target selectivity and stimulus response.

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Section: Types Of Polymer Nanocarriersmentioning

confidence: 99%

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Chakraborty,

Meher,

Dash

et al. 2023

ChemistrySelect

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“…The number of chain ends increases exponentially as the dendrimer generations increase. Several studies show the beneficial effects arising from the multiple chain ends. , Prominent examples of the studies are (i) the specific rotation neutrality of multiple, covalently attached chiral moieties at the peripheries of the dendrimers; (ii) the formation of charge-transfer complexes in dendrimers functionalized with electron-rich moieties and their interaction with relevant acceptors; − and (iii) acceleration of the catalytic effects in metal catalysis. − Ligand clustering at the dendritic scaffolds provides an opportunity to identify the cluster effects on the ligand properties. This clustering enables to study (i) dendrimer effects in ligand–receptor interactions; − (ii) cluster effects in organometallic catalysis; − (iii) antenna effects in electron and energy transfer processes; − and (iv) macromolecular and supramolecular complexation properties. − Recent reports demonstrate (i) the convergent synthesis of hexaphenylbenzene core biphenyl-dendrimers and their surface modification with β-(1/6)-linked glucosamine as multivalent carbohydrate mimics to uncover biological activities and (ii) facile synthesis of higher generation dendrimers, with dense peripheral functional surface groups, involving click and thiol-ene reactions under microwave conditions .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Studies of Pyridoneimine-Functionalized PETIM Dendrimers

Dey,

Jayaraman

2023

ACS Omega

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Pyridinoimine-functionalized poly(ether imine) (PETIM) dendrimers of 1−3 generations, possessing 4−16 moieties at the peripheries, are synthesized. Chloride-functionalized dendrimers are reacted with N-methylamino pyridine, under basic conditions, which led to functionalization of the peripheries of a dendrimer with pyridoneimine moieties. Variable-temperature 1 H NMR studies are performed to assess the contributing resonance forms of pyridoneimine in the dendrimers. Solvatochromism and 15 N NMR studies aid further the assessment of the contributing resonance forms. Comparison with derivatives that possess 1 and 2 pyridoneimines illustrates the contributing resonance forms between nonaromatic pyridoneimine and zwitter ionic aromatic imidopyridinium species.

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“…The discipline of supramolecular chemistry [1] is a prominent field that describes the interaction of molecules via non-covalent DOI: 10.1002/macp.202300274 interactions such as hydrogen bonding, electrostatic interaction, or van der Waals forces to generate (macromolecular) assemblies. [2][3][4] Designing supramolecular constructs within various dimensions and shapes into well-defined nanostructures have attracted tremendous interest aiming to mimic the complexity of natural assemblies. [5] One prominent method to fabricate such nanostructures relies on the solution self-assembly of amphiphilic block copolymers (BCPs), providing access to a variety of morphologies having the shape of spheres, cylinders/worms, or "fiberlike" micelles, platelets, and vesicles.…”

Section: Introductionmentioning

confidence: 99%

PLLA‐Based Block Copolymers via Raft Polymerization—Impact of the Synthetic Route and Activation Mechanism

Alsawaf,

Kanehira,

Bapolisi

et al. 2023

Macro Chemistry & Physics

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Designing supramolecular structures with well‐defined dimensions and diverse morphologies via the self‐assembly of block copolymers has long been renowned. Specifically, the design of one‐dimensional fiber nanostructures has been extensively emphasized, due to their unique properties in many areas, such as microelectronics, photonics, and particularly in the biomedical field. Herein, amphiphilic diblock copolymers of P(L‐lactide)‐b‐P(N‐t‐butoxy‐carbonyl‐N´‐acryloyl‐1,2‐diaminoethane)‐co‐P(N‐isopropylacrylamide) PLLAn‐b‐P(BocAEAm)m‐co‐ P(NiPAAm)Ɩ were developed. Two synthetic strategies have been investigated to equip PLLA with a chain transfer agent (CTA), either by Steglich esterification of PLLA‐OH or via the ring‐opening polymerization of L‐lactide using a CTA containing a hydroxyl functional group. The second strategy proved to be superior in terms of degree of functionalization. The corona‐forming blocks, with degrees of polymerization of 200 and above were achieved in good definition by photo‐iniferter RAFT polymerization (Đ ≤ 1.25), while a Đ of 1.75 was obtained by conventional RAFT polymerization. The self‐assembly of the developed system leads to the formation of nanofibers with a height of 11 nm and a length of around 300 nm, which has been determined by atomic force microscopy (AFM). These fibers will be the basis for new antimicrobial nanomaterials after deprotection, as the subject of upcoming work.This article is protected by copyright. All rights reserved

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Dendrimers

Cited by 18 publications

References 412 publications

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Strategies for Targeted Delivery via Structurally Variant Polymeric Nanocarriers

Synthesis and Studies of Pyridoneimine-Functionalized PETIM Dendrimers

PLLA‐Based Block Copolymers via Raft Polymerization—Impact of the Synthetic Route and Activation Mechanism

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