Dendrimeric Micelles for Controlled Drug Release and Targeted Delivery

Ambade, Ashootosh V.; Savariar, Elamprakash N.; Thayumanavan, S.

doi:10.1021/mp050020d

Cited by 221 publications

(187 citation statements)

References 51 publications

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“…Novel dendrimeric systems for applications as nano-scale drug-delivery systems include biaryl-based dendrimeric micelles that exhibit environment-dependent conformations [94], 'bow-tie' architectures that covalently connect a drug-loaded dendron to a PEGylated, solubilizing dendron [25] and hybrid dendrimer-based microcapsules that enable a dual release scheme [95]. In addition to serving as drug-delivery vectors, dendrimers can act as inherently-active antitumor, antiviral and antibacterial agents [96] and as permeability enhancers that can promote oral and transdermal drug delivery [93,97].…”

Section: Dendrimersmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

932

554

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Research in the areas of drug delivery and tissue engineering has witnessed tremendous progress in recent years due to their unlimited potential to improve human health. Meanwhile, the development of nanotechnology provides opportunities to characterize, manipulate and organize matter systematically at the nanometer scale. Biomaterials with nano-scale organizations have been used as controlled release reservoirs for drug delivery and artificial matrices for tissue engineering. Drug-delivery systems can be synthesized with controlled composition, shape, size and morphology. Their surface properties can be manipulated to increase solubility, immunocompatibility and cellular uptake. The limitations of current drug delivery systems include suboptimal bioavailability, limited effective targeting and potential cytotoxicity. Promising and versatile nano-scale drug-delivery systems include nanoparticles, nanocapsules, nanotubes, nanogels and dendrimers. They can be used to deliver both small-molecule drugs and various classes of biomacromolecules, such as peptides, proteins, plasmid DNA and synthetic oligodeoxynucleotides. Whereas traditional tissue-engineering scaffolds were based on hydrolytically degradable macroporous materials, current approaches emphasize the control over cell behaviors and tissue formation by nano-scale topography that closely mimics the natural extracellular matrix (ECM). The understanding that the natural ECM is a multifunctional nanocomposite motivated researchers to develop nanofibrous scaffolds through electrospinning or self-assembly. Nanocomposites containing nanocrystals have been shown to elicit active bone growth. Drug delivery and tissue engineering are closely related fields. In fact, tissue engineering can be viewed as a special case of drug delivery where the goal is to accomplish controlled delivery of mammalian cells. Controlled release of therapeutic factors in turn will enhance the efficacy of tissue engineering. From a materials point of view, both the drug-delivery vehicles and tissue-engineering scaffolds need to be biocompatible and biodegradable. The biological functions of encapsulated drugs and cells can be dramatically enhanced by designing biomaterials with controlled organizations at the nanometer scale. This review summarizes the most recent development in utilizing nanostructured materials for applications in drug delivery and tissue engineering.

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Section: Dendrimersmentioning

confidence: 99%

Nanostructured materials for applications in drug delivery and tissue engineering

Goldberg

Langer

Jia

2007

Journal of Biomaterials Science, Polymer Edition

932

554

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“…It can be seen that the free PAMAM-G3 and PAMAM-G4 Figure 1A & 1B are spherical crystalline structures, with mean dimensions of 10 ± 2 nm [34][35][36][37][38][39][40][41], while testosterone-PAMAM, present average dimensions of 19 ± 3 nm ( Figures 1A, 1B, 1E & 1F) [28]. The results show that the steroid-PAMAM nanoparticles were larger in size than the free PAMAM due to testosterone encapsulation.…”

Section: Tem Images and The Morphology Of Testosteronepolymer Aggregatesmentioning

confidence: 93%

Review on Testosterone Delivery by Natural and Synthetic Nanoparticles

Riahi¹

2017

JNMR

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IntroductionNatural and synthetic polymers are widely used as drug delivery tools in pharmaceutical and nanomedicine biotechnology [1][2][3][4][5]. Among synthetic polymers, dendrimers, a family of cationic polymers, are promising nonviral vectors for gene and drug delivery because of a well-defined molecular shape, controlled chemical structure, high water solubility, large number of chemically versatile surface groups, and unique architecture [6][7][8]. Natural cationic polymers such as chitosan are attractive candidates for therapeutic applications as they generally are nontoxic, being derived from renewable resources [9]. Biodegradable, biocompatible and nontoxic chitosan nanoparticles are of a major interest in drug delivery systems. They form complexes with antibiotics, anticancer drugs and therapeutic proteins [10][11][12]. Chitosan and its derivatives have the desired properties for safe use as pharmaceutical drug delivery tools. This has prompted accelerated research activities worldwide on chitosan nanoparticles as drug delivery tools [13][14][15][16].Testosterone is the main androgenic hormone which controls many physiological processes such as, sexual functions and secondary sex characteristics, muscle protein metabolism, plasma lipid and bone metabolism [17]. Testosterone can also be used as a natural template to construct semi-synthetic analogues such as dimers, testosterone amide derivatives, as well as testosteronecytotoxic hybrid molecules [18][19][20][21][22]. These novel semi-synthetic molecules can be tested for their biological properties, using diverse spectroscopic methods [18][19][20][21][22][23][24][25]. Synthetic polymers are used as potential nanocarriers to deliver steroids in vitro and in vivo [26][27][28]. Furthermore, chitosan and its derivatives were also tested as delivery tools for transporting steroids [29,30].In this review, the binding efficacies of testosterone with PAMAM dendrimers and chitosan nanoparticles were compared, using multiple spectroscopic, TEM images and molecular modeling results. Structural analysis regarding testosterone binding process and the effect of steroid-polymer conjugation on polymer morphology as well as the possibility of testosterone delivery by PAMAM and chitosan nanoparticles are discussed here. Experimental Transmission electron microscopyThe TEM images were taken using a Philips EM 208S microscope operating at 180 kV. The morphology of the testosterone conjugates with PAMAM dendrimers and chitosan nanoparticles in aqueous solution at pH 7.4 were observed, using transmission electron microscopy. One drop (5-10 µL) of the freshly-prepared mixture [polymer solution (60 µM) + steroid solution (60 µM)] in Tris-HCl buffer (24 ± 1°C) was deposited onto a glow-discharged carbon-coated electron microscopy grid. The excess liquid was absorbed by a piece of filter paper, and a drop of 2% uranyl acetate negative stain was added before drying at room temperature [28]. UV spectroscopyThe UV-Vis spectra were recorded on a Perkin-Elmer Lambda AbstractThe lo...

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“…Synthetic polymers capable of specific recognition have found applications in a variety of fields, from chemical sensing (Rimmel and Bäuelre, 1999;Scheib and Bäuerle, 1999;McQuade et al, 2000) to separations (Daniel et al, 1989;Xinjian et al, 2007;Priego-Capote et al, 2008) and drug delivery (Yasugi et al, 1999;Ambade et al, 2005;Lim Soo et al, 2005;Paleos et al, 2006;Li and Wallace, 2008). The area of polymer therapeutics, in particular, has evolved to include polymer-drug and polymer-protein conjugates, molecularly imprinted polymers (Yang and Li, 2005;Huiqi et al, 2006;Ye and Mosbach, 2008;Meng et al, 2009), and polymeric micelles containing covalently bound drugs (Kolhe et al, 2004;Patri et al, 2005;Khandare and Minko, 2006;Vicent and Duncan, 2006;Boyer et al, 2007;Fox et al, 2009;Krakoviˇcová et al, 2009;Prabaharan et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Receptor‐attached amphiphilic terpolymer for selective drug recognition in aqueous solutions

Loizidou

Sun

Zeinalipour-Yazdi³

2011

J of Molecular Recognition

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In the present work, a combination of binding studies and molecular docking were employed to demonstrate drug encapsulation and host-guest chemistry in self-assembled micelles consisting of amphiphilic terpolymers. The terpolymer is composed of poly(3-sulfopropyl methacrylate), as the hydrophilic component, poly(n-dodecyl acrylate), as the hydrophobic component and poly(barbiturate receptor), as the component for drug recognition. The combined approach was tested on four model compounds from the family of barbiturates, phenobarbital, mephobarbital, secobarbital, and thiopental, chosen based on their differential hydrogen bonding capabilities. Drug encapsulation and hydrogen-bonding based recognition within the micellar core of the receptor-terpolymer was demonstrated by micellar electrokinetic chromatography. The resulting trends in the binding affinity of the barbiturates to the receptor-terpolymer, were correlated to the trends obtained from computational docking simulations. This receptor-modified polymeric micelle is intended to serve as a model for the design of novel, versatile, and highly selective molecular scaffolds that will provide suitable environment for host-guest chemistry and act as simplified mimics to more complex biological systems.

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Dendrimeric Micelles for Controlled Drug Release and Targeted Delivery

Cited by 221 publications

References 51 publications

Nanostructured materials for applications in drug delivery and tissue engineering

Nanostructured materials for applications in drug delivery and tissue engineering

Review on Testosterone Delivery by Natural and Synthetic Nanoparticles

Receptor‐attached amphiphilic terpolymer for selective drug recognition in aqueous solutions

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