Dendrimer-Modified Silica Nanoparticles for Efficient Enrichment of Low-Concentration Peptides

Qu, Chengxue; Shu, Weikang; Xie, Fengjuan; Liu, Yang; Li, Rongxin; Pei, Congcong; Wan, Jingjing

doi:10.1007/s12010-022-03892-x

Cited by 4 publications

(5 citation statements)

References 46 publications

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“…Reproduced with permission. [58] Copyright 2022, Springer Nature. such as simple, rapid, high sensitivity, and reproducibility application, which can be attributed to the 𝜋-conjugated network, the abundant carboxyl and hydroxyl groups on the CDs surface, the thin layer of matrix crystal, and 9AA ionization suppression by CDs.…”

Section: Carbon-based and Silicon-based Nanomaterialsmentioning

confidence: 99%

“…The nanocomposites displayed excellent peptide enrichment properties owing to the merits of dendrimer (branch-like structure and modifiable surface) and mesoporous silica nanomaterials (large surface area and adjustable pore size). [58] Li et al prepared SiO 2 @Au nanoshells, in which SiO 2 of the excellent heat storage performance combined with Au of the SPR to enhance the ionization efficiency and improve sensitivity. [65] With the development of lithography, silicon-based nanomaterials can be exquisitely designed as silicon nanoarrays, silicon wafers, and silicon microcolumns with the careful tuning of physical properties through the array geometry and optimization of nanophotonic performance.…”

Section: Carbon-based and Silicon-based Nanomaterialsmentioning

confidence: 99%

“…The nanocomposites displayed excellent peptide enrichment properties owing to the merits of dendrimer (branch‐like structure and modifiable surface) and mesoporous silica nanomaterials (large surface area and adjustable pore size). [ 58 ] Li et al. prepared SiO 2 @Au nanoshells, in which SiO 2 of the excellent heat storage performance combined with Au of the SPR to enhance the ionization efficiency and improve sensitivity.…”

Section: The Designed Nanomaterialsmentioning

confidence: 99%

mentioning

confidence: 99%

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Designed Nanomaterials‐Assisted Proteomics and Metabolomics Analysis for In Vitro Diagnosis

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Shu

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In vitro diagnosis (IVD) is pivotal in modern medicine, enabling early disease detection and treatment optimization. Omics technologies, particularly proteomics and metabolomics, offer profound insights into IVD. Despite its significance, omics analyses for IVD face challenges, including low analyte concentrations and the complexity of biological environments. In addition, the direct omics analysis by mass spectrometry (MS) is often hampered by issues like large sample volume requirements and poor ionization efficiency. Through manipulating their size, surface charge, and functionalization, as well as the nanoparticle‐fluid incubation conditions, nanomaterials have emerged as a promising solution to extract biomolecules and enhance the desorption/ionization efficiency in MS detection. This review delves into the last five years of nanomaterial applications in omics, focusing on their role in the enrichment, separation, and ionization analysis of proteins and metabolites for IVD. It aims to provide a comprehensive update on nanomaterial design and application in omics, highlighting their potential to revolutionize IVD.

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Section: Carbon-based and Silicon-based Nanomaterialsmentioning

confidence: 99%

Section: Carbon-based and Silicon-based Nanomaterialsmentioning

confidence: 99%

Section: The Designed Nanomaterialsmentioning

confidence: 99%

mentioning

confidence: 99%

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Designed Nanomaterials‐Assisted Proteomics and Metabolomics Analysis for In Vitro Diagnosis

Wang,

Li,

Shu

et al. 2023

Small Methods

Self Cite

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“…In recent years, nanomaterials have significantly transformed the landscape of biomedical science by providing innovative solutions to a multitude of challenges. Materials such as carbon nanoparticles, [ 21 ] bionanoparticles, [ 22 ] metal nanoparticles, [ 23 ] and silica nanoparticles [ 24 ] have garnered considerable attention in the realm of biomedical advancements. They exhibit immense potential in areas including targeted drug delivery, enhanced medical imaging, tissue engineering, regenerative medicine, and combined therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

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Liu

et al. 2023

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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Organic Nanoparticles in Anti-angiogenic Cancer Therapy

Mukherjee

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2022

Nanoparticles in Angiogenesis and Cancer

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Dendrimer-Modified Silica Nanoparticles for Efficient Enrichment of Low-Concentration Peptides

Cited by 4 publications

References 46 publications

Designed Nanomaterials‐Assisted Proteomics and Metabolomics Analysis for In Vitro Diagnosis

Designed Nanomaterials‐Assisted Proteomics and Metabolomics Analysis for In Vitro Diagnosis

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Organic Nanoparticles in Anti-angiogenic Cancer Therapy

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