Dendrimer-Modified Magnetic Nanoparticles Enhance Efficiency of Gene Delivery System

Pan, Bifeng; Cui, Daxiang; Sheng, Yuan; Ozkan, Cengiz S.; Gao, Feng; He, Rong; Li, Qing; Xu, Ping; Huang, Tuo

doi:10.1158/0008-5472.can-06-4762

Cited by 291 publications

(166 citation statements)

References 40 publications

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“…A number of cationic polymers (e.g. poly(ethylene imine) [85] and poly(dimethyaminoethyl (meth)acrylate) [86]) have been grafted onto IONPs and used for conjugation with siRNA via electrostatic interactions. Pan et al [85] developed PEI-coated IONPs for the encapsulation of genes and demonstrated successful in vitro delivery.…”

Section: Review Articlementioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

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Iron-oxide nanoparticles (IONPs) represent a significant class of inorganic nanomaterial that is contributing to the current revolution in nanomedicine [1][2]. Their unique physical properties, including high surface area to volume ratios and superparamagnetism, confer useful attributes for medical applications such as magnetic resonance imaging (MRI), drug and gene delivery, tissue engineering and bioseparation [3].Two distinct classes of superparamagnetic IONP-based materials are currently used for medical applications: superparamagnetic iron-oxide (SPIO) nanoparticles with a mean particle diameter of 50-100 nm, and ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles with a size below 50 nm. Th ese two classes of IONPs have been studied widely for medical applications, particularly as the next (potential) generation of MRI contrast agents. Th ey are also seen as potential vectors for drug and gene delivery. Th e biodistribution of these nanoparticles can be altered by the application of an external magnetic fi eld; they also have potential applications in hyperthermia therapy as some magnetic particles can heat up under the infl uence of a localized high-frequency magnetic fi eld.Th e intent of this review is to present recent advances in the synthesis of IONPs and their subsequent stabilization in biological fluids using polymers, focusing on the current strategies used to graft polymers onto IONPs surfaces (see Figure 1) and the diff erent types of polymers used. Th e additional properties conferred by the polymers, such as targeting, eff ects on biodistribution and pharmacokinetics, are also discussed, and the main applications of IONPs are reviewed. Synthesis and properties of iron-oxide nanoparticlesSPIO and USPIO nanoparticles are the most extensively studied magnetic nanoparticles for biomedical applications as they are both biocompatible and easy to synthesize. Both are composed of ferrite nanocrystallites of magnetite (Fe 3 O 4 ) or maghemite (Fe 2 O 3 , γ). Over the last ten years, there has been an explosion of interest in these materials and this has been reflected in a large number of recent publications describing the synthesis and modifi cation of hybrid IONPs. In this review, we focus on the polymer modifi cation of the nanoparticles, and provide only minimal information on the inorganic synthesis of IONPs. For more detailed information on IONP synthesis, readers are referred to other reviews [3,4]. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applicationsCyrille Boyer 1 * , Michael R. Whittaker 1 , Volga Bulmus 2 , Jingquan Liu 1 and Thomas P. Davis 1 * University of New South Wales, AustraliaOver the past decade, the synthesis of superparamagnetic nanoparticles, especially iron-oxide nanoparticles (IONPs), has been researched intensively for many high-technology applications, including enhanced storage media, biosensing and medical applications. In medicine, IONPs are used as contrast agents in magnetic resonance imaging and in hyperthermia...

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Section: Review Articlementioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

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“…To have a highly sensitive biosensor with a fast response and a specific application, the choice of the material of sensor is very important. Several nanomaterials such as nanowires/nanotubes [24], gold nanoparticles [23], magnetic nanoparticles [25], carbon nanotubes [26] and quantum dots [27] have been investigated to evaluate their application as biosensors. Experiments have looked at their physical, chemical, mechanical, magnetic and optical properties for increased sensitivity, faster response and specific biomolecules recognition.…”

Section: Introductionmentioning

confidence: 99%

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Khun¹

2015

Linköping Studies in Science and Technology. Dissertations

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Research on nanomaterials has been revolutionized in the last few years because of the attractive properties they have in comparison to the bulk phase of similar materials. These properties are physical, chemical, catalytic and optical. Among these nanomaterials, the metal oxide nanostructures have become of particular interest to scientists for the development of different optical, biochemical and biomedical nanodevices. In the present research work using the advantageous features of nanotechnology, high performance nanodevices for optoelectronics with a wide band gap compound nanostructure and highly sensitive sensor devices have been demonstrated. The nanotechnology is used to fabricate sensitive and precise nanodevices based on nanomaterials for the application of sensing.Among metal oxide nanostructures, ZnO, CuO and NiO are attractive materials because of their unique properties; their high surface area to volume ratio, their energy band gap of 3.37 eV, 1.2 eV and 3.7 eV, respectively, biocompatibility, high electron mobility, fast electron transfer rate and they are environmental-friendly in many applications. When used in sensor devices, nanomaterials have indicated high selectivity for possible use to detect the various analytes even in small volumes. Metal oxide nanostructures have shown to be good for optoelectronic nanodevices because of their electrical characteristics, high optical absorption and low-processing temperature.In this thesis, the synthesis of different morphologies of metal oxide semiconductor nanostructures and their composite using the hydrothermal method are demonstrated for various applications. This thesis is divided into three parts:In the first part of this research work, the fabrication of well-aligned ZnO nanorods using different concentrations of composite seed layer of inorganic and organic materials when using the hydrothermal growth method is presented. The effect of the composite seed layer on the i Abstract alignment, density and optical properties of the grown ZnO nanorods is investigated (paper I).Utilizing the advantage of ZnO nanostructure, a comparative study of ZnO nanorods and thin films for chemical and biosensing application was carried out. The ZnO nanorods and thin films were functionalized with strontium ionophore membrane, immobilized the galactose oxidase and lactate oxidase for determining the strontium ions, D-galactose and L-lactic acid, respectively (paper II).In the second part, the effects of different urea concentrations on the morphology of CuO nanostructures is studied as described in paper III. Moreover, CuO nanoflowers were functionalized with cadmium ion ionophore for the detection of Cd ions, while CuO nanosheets were grown by the low temperature growth method and were used for the development of a nonenzymatic glucose sensor, respectively (Paper IV).In the last part of this thesis, composite nanostructures of CuO/ZnO and NiO/ZnO were applied to develop dopamine sensor and fast sensitive UV photodetector, respectively. A nanohybrid of C...

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“…In fact, both in vitro and in vivo studies demonstrated that microspheremediated delivery of rAAV vector results in higher transduction efficiencies than delivery of free vector alone, when administered either intramuscularly or intravenously (Mah et al 2002). Currently, in vitro magnetofection kits utilizing cationic polymer coated MNPs are commercially available (Mykhaylyk et al 2007;Pan et al 2007;Ryther et al 2005;Schillinger et al 2005). Huth et al showed that the cationic polymeric gene carriers, such as polyethylenimine (PEI) increase the cellular uptake of magnetofectins (Huth et al 2004).…”

Section: Magnetic Nanoparticles For Gene Deliverymentioning

confidence: 99%

Magnetic nanoparticle drug delivery systems for targeting tumor

et al. 2013

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Tumor hypoxia, or low oxygen concentration, is a result of disordered vasculature that lead to distinctive hypoxic microenvironments not found in normal tissues. Many traditional anti-cancer agents are not able to penetrate into these hypoxic zones, whereas, conventional cancer therapies that work by blocking cell division are not effective to treat tumors within hypoxic zones. Under these circumstances the use of magnetic nanoparticles as a drug delivering agent system under the influence of external magnetic field has received much attention, based on their simplicity, ease of preparation, and ability to tailor their properties for specific biological applications. Hence in this review article we have reviewed current magnetic drug delivery systems, along with their application and clinical status in the field of magnetic drug delivery.

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Dendrimer-Modified Magnetic Nanoparticles Enhance Efficiency of Gene Delivery System

Cited by 291 publications

References 40 publications

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

Synthesising Metal Oxide Materials and Their Composite Nanostructures for Sensing and Optoelectronic Device Applications

Magnetic nanoparticle drug delivery systems for targeting tumor

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