Dendrimer construction and macromolecular property modification via combinatorial methods

Newkome, George R.; Childs, Bradley J.; Rourk, Michael J.; Baker, Gregory R.; Moorefield, Charles N.

doi:10.1002/(sici)1097-0290(1998)61:4<243::aid-cc6>3.3.co;2-1

Cited by 5 publications

(4 citation statements)

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“…Future development of combinatorial synthetic protocols could also alleviate the temporal and financial burden imposed by the traditional synthesis-evaluation sequence. Pioneering studies on the construction of 'compositional' dendrimers indicate that this is the most suitable strategy for rapid accumulation of dendritic "libraries" [159,160]. The chemical or physical coating of "classic" nanoparticles with functional dendritic fragments deserves special attention due to the numerous advantages for the creation of advanced materials and additives.…”

Section: Discussionmentioning

confidence: 99%

Dendrimers - Nanoparticles with Precisely Engineered Surfaces

Gitsov¹

2005

COC

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Dendritic macromolecules or "dendrimers" are artificial nanoparticles with precisely defined covalent macromolecular architecture and broad application potential. Their discovery, construction strategies, postsynthetic peripheral modifications, surface-related properties and selected potential applications are the subject of this review. The standard dendrimer is characterized by three distinct zones, the periphery, the interior, and the core. All formation approaches ultimately yield structures with these spatial arrangements. The specific interactions of the dendritic molecules with their local nanoenvironment is determined by factors that include the nature of starting building blocks, the synthetic pathway, and more importantly -the postformation modifications on the periphery of the dendritic globules or to a minor extent -on their interior. The review examines the different chemistries used to tailor dendrimers and their properties for specific applications.

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Section: Discussionmentioning

confidence: 99%

Dendrimers - Nanoparticles with Precisely Engineered Surfaces

Gitsov¹

2005

COC

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“…[1][2][3][4][5] Newkome considered them also as monodisperse polymeric materials with specific size, high degree of molecular uniformity, porosity, solubility and highly functional terminal groups on the surface. [6][7][8][9][10] The first reported dendrimer synthesis was in 1978, by Fritz Vögtle. 11 At present there are many groups around the world which have contributed to the physics and chemistry of dendrimers.…”

Section: Introductionmentioning

confidence: 95%

Dendrimers as Novel Polymeric Material: A Review on Its Synthesis, Characterization and Their Applications

Nasibullah¹,

Hassan²,

Ahmad³

et al. 2013

Advanced Science Focus

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Dendrimers are a new class of monodisperse polymeric materials. They are highly branched, fractal like macromolecules of defined shape, size and topology. There are two main synthetic methods for the preparation of dendrimers, the convergent and the divergent syntheses. Dendrimers are usually characterized by size exclusion chromatography (SEC), light scattering measurement, Thermogravimetric analysis (TGA), Fluoresence microscopy, NMR spectroscopy, IR spectroscopy, UV visible spectroscopy, Maldi TOF Mass spectrometry, AFM microscopy and Transmission electron microscopy (TEM). They play an important role in the field of nanotechnology, biotechnology, healthcare, pharmaceuticals, vaccine and drug delivery, electronic devices, photonics, engineering products, catalysis, sensors and environmental issues. This review summaries the synthesis, characterization of dendrimers and their applications.

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“…The polymer has a high degree of molecular uniformity and a very narrow molecular weight distribution. It has many reactive terminal groups and diverse applications [2] that include drug delivery using the polymer-mediated enhanced solubility [3] or the modified outward functional groups [4]. Also, the polymer is potentially useful as a sensor of carbon monoxide gas via modification of terminal groups [5] and as a glucose sensor via the polymer-mediated electron transfer from glucose oxidase to an electrode [6,7].…”

Section: Introductionmentioning

confidence: 99%

Improved DNA chip with poly(amidoamine) dendrimer peripherally modified with biotin and avidin

Lim

Kim

Lee

et al. 2008

Biotechnol Bioproc E

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Important properties for a biosensor are the sensitive detection of target DNA at low concentration, the specific and accurate distinction of the target and other DNA having a similar sequence, and measurement capability over a wide range of target concentrations. To these ends, generation 3 polyamidoamine (PAMAM) dendrimer was used to improve DNA chip properties. PAMAM dendrimer surface amine moieties were modified to biotin and immobilized on glass slides using biotin-avidin conjugation. The surface morphologies of the avidin-biotin-dendrimer complexes were observed using atomic force microscopy and scanning electron microscopy. Detection sensitivity for fluorescence-labeled target DNA increased approximately 4-fold by the dendrimer coating. Dendrimer coating also markedly improved the dynamic range and detection of single nucleotide polymorphisms. Dendrimer complex morphology had little effect on the sensitivity. © KSBB

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Dendrimer construction and macromolecular property modification via combinatorial methods

Cited by 5 publications

References 0 publications

Dendrimers - Nanoparticles with Precisely Engineered Surfaces

Dendrimers - Nanoparticles with Precisely Engineered Surfaces

Dendrimers as Novel Polymeric Material: A Review on Its Synthesis, Characterization and Their Applications

Improved DNA chip with poly(amidoamine) dendrimer peripherally modified with biotin and avidin

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